Updated on 2025/09/30

写真a

 
UEDA,Kimiko
 
Organization
Faculty of Health and Well-being Professor
Title
Professor
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Degree

  • 博士(医学) ( 2003.12   自治医科大学 )

  • MPH ( 2001.6   ハーバード大学 )

  • 医学士 ( 1996.3   自治医科大学 )

Research Interests

  • Well-being for people with disability

  • early childhood intervention

  • Down Syndrome

  • Pediatric Clinical Genetics

  • Public Health

  • Social Epidemiology

  • Maternal and Child Health

  • Family empowerment

Research Areas

  • Humanities & Social Sciences / Social welfare  / Well-being for people with disabilty

  • Humanities & Social Sciences / Childhood and nursery/pre-school education  / Early childhood Intervention

  • Humanities & Social Sciences / Childhood and nursery/pre-school education  / Inclusive Schooling

  • Life Science / Embryonic medicine and pediatrics  / Pediatric Cliniclal Genetics

  • Life Science / Hygiene and public health (non-laboratory)  / Social Epidemiology

  • Life Science / Hygiene and public health (non-laboratory)  / Maternal and Child Health

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Committee Memberships

  •   出生前検査認証制度等運営委員会情報提供ワーキンググループ  

       

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  •   日本公衆衛生学会編集委員会  

       

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  •   NIPT等の出生前検査に関する専門委員会  

       

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Papers

  • Improving Care for Preschool Children with Disabilities During Disasters in Japan. International journal

    Koji Yamawaki, Aya Goto, Kimiko Ueda

    Health systems and reform   11 ( 1 )   2521185 - 2521185   2025.12

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    This commentary traces the origins of Japan's special education system and explores the need to equip preschool teachers with the specific knowledge and skills necessary to care for children under the age of six with disabilities during disasters in Japan. Japan's slow implementation of inclusive education, in which children with and without disabilities are educated together, was noted by the UN Committee on the Rights of Persons with Disabilities in 2022. The Committee also recommended improved care for persons with disabilities in disaster situations and humanitarian emergencies. Historically, Japan has promoted policies that segregate children with disabilities from children without disabilities. Integrated childcare began in the 1970s, but there continues to be a lack of suitable systems and practical guidelines for disaster management in inclusive childcare. The curricula of institutions that train childcare professionals were reviewed. As of April 1, 2023, there were 666 designated childcare teacher training institutions in Japan. Of these, 498 training institutions offered courses to obtain both kindergarten and nursery teaching licenses. Thirty-seven of the institutions were national and public schools, of which the present study included 36 schools whose syllabus was available online and whose course content could be confirmed. Only one school (2.8%) was found to include "disaster and childcare" in its curriculum, and three schools (8.3%) included "safety of children with disabilities" in their curriculum. Specialist disaster preparedness training to enable teachers to care for preschool children with disabilities in the event of a disaster is critical in the context of inclusive childcare.

    DOI: 10.1080/23288604.2025.2521185

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  • An Exploratory Cross-Sectional Study on Thyroid Hormone Reference Intervals in Children With Down syndrome. International journal

    Ayako Konishi, Kimiko Ueda, Nobuhiko Okamoto, Shinobu Ida, Yuri Etani, Masanobu Kawai

    Clinical endocrinology   103 ( 1 )   74 - 81   2025.7

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    OBJECTIVE: Accurate evaluation of thyroid dysfunction in children with Down syndrome is challenging because of the lack of age-specific reference intervals in these individuals. This study aimed to establish age-specific reference intervals for thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels in children with Down syndrome. METHODS: A retrospective cross-sectional study was conducted on children with Down syndrome, aged 6 months to 15 years, who visited the Osaka Women's and Children's Hospital between April 2019 and March 2020. Subjects who had used medications that influenced thyroid function or who lacked thyroid hormone data were excluded from the study. The final analysis included 301 subjects. Serum TSH and FT4 levels were measured, and reference intervals were calculated using nonparametric methods. RESULTS: The reference intervals for TSH in children with Down syndrome were 2.03-14.22, 1.79-12.98, 1.26-10.24, and 0.58-10.11 mIU/L in infants, toddlers, school children, and adolescents, respectively, which were higher than those observed in the general paediatric population. The reference intervals for FT4 were 13.57-26.42, 13.20-22.70, 13.15-22.36, and 11.97-24.77 pmol/L, respectively, which were comparable to those of the general paediatric population. Multivariate regression analyses revealed a significant inverse association between age and the levels of TSH and FT4 (p < 0.01). CONCLUSIONS: We provide evidence for age-specific reference intervals for TSH and FT4 levels in children with Down syndrome, which may help clinicians accurately evaluate thyroid hormone status.

    DOI: 10.1111/cen.15236

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  • Risk score for non-vaccination of voluntary vaccines: The Japan Environment and Children's Study. International journal

    Masashi Hotta, Kimiko Ueda, Satoyo Ikehara, Kanami Tanigawa, Hirofumi Nakayama, Kazuko Wada, Tadashi Kimura, Keiichi Ozono, Tomotaka Sobue, Hiroyasu Iso

    Pediatrics international : official journal of the Japan Pediatric Society   67 ( 1 )   e15888   2025

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    BACKGROUND: In Japan, as several important vaccines are still categorized as voluntary vaccines that require out-of-pocket payment, the vaccination coverage of voluntary vaccines is lower than that of routine vaccines. Thus, higher voluntary vaccination rates are desired. Herein, we used nationwide birth cohort data to create a voluntary vaccine risk score to identify high-risk individuals who were not vaccinated with voluntary vaccines. METHODS: The data from 74,733; 73,571; and 74,360 infants were analyzed for rotavirus, mumps virus, and influenza virus vaccinations, respectively. The risk score for non-vaccination of voluntary vaccines was created from the regression coefficients of the logistic regression models. RESULTS: The items included for the score resulted from the analysis were the mother's drug allergy history, mother's depression history, mother's educational background, father's educational background, household income, maternal smoking during pregnancy, paternal smoking during pregnancy, fertility treatment, number of siblings, maternal drinking at 1 month of age, maternal age, and maternal nationality. The mother's drug allergy history, mother's depression history, fertility treatment, maternal drinking at 1 month of age, and maternal nationality were factors not previously reported and associated with taking voluntary vaccine. The receiver operating characteristic curve of the risk score for non-vaccination of voluntary vaccines suggested that a score ≥16 predicted non-vaccinated infants for rotavirus, mumps virus, and influenza virus vaccines with 78.6%, 75.0%, and 74.5% sensitivity and 44.2%, 43.2%, and 37.1% specificity, respectively. CONCLUSIONS: We developed a risk score for non-vaccination of voluntary vaccines consisting of 10 domains with high sensitivity but low specificity.

    DOI: 10.1111/ped.15888

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  • Growth and respiratory status at 3 years of age after moderate preterm, late preterm and early term births: the Japan Environment and Children's Study. Reviewed International journal

    Katsuya Hirata, Kimiko Ueda, Satoyo Ikehara, Kanami Tanigawa, Kazuko Wada, Tadashi Kimura, Keiichi Ozono, Tomotaka Sobue, Hiroyasu Iso

    Archives of disease in childhood. Fetal and neonatal edition   2024.7

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    OBJECTIVE: To assess the association between gestational age at birth and the risk of growth failure and respiratory symptoms at 3 years of age. DESIGN: Cohort study using the Japan Environment and Children's Study database. PATIENTS: A total of 86 158 singleton infants born without physical abnormalities at 32-41 weeks of gestation were enrolled between January 2011 and March 2014. MAIN OUTCOME MEASURES: Growth failure (weight <10th percentile and height <10th percentile) and respiratory symptoms (asthma and wheezing) at 3 years of age. METHODS: Logistic regression analysis was used to evaluate the risk of growth failure and respiratory symptoms in the moderately preterm, late preterm and early term groups compared with the full-term group after adjusting for socioeconomic and perinatal factors. Multiple imputation was used to reduce the attrition bias related to missing data. RESULTS: The respective adjusted ORs (95% CI) of growth failure and respiratory symptoms for the moderate preterm, late preterm and early term groups compared with the full-term group were as follows: weight <10th percentile, 2.29 (1.48-3.54), 1.43 (1.24-1.71) and 1.20 (1.12-1.28); height <10th percentile, 2.34 (1.59-3.45), 1.42 (1.25-1.60) and 1.15 (1.09-1.22); asthma, 1.63 (1.06-2.50), 1.21 (1.04-1.41) and 1.16 (1.09-1.23); and wheezing, 1.39 (1.02-1.90), 1.37 (1.25-1.51) and 1.11 (1.06-1.17). CONCLUSION: Moderate preterm, late preterm and early term births were associated with a higher risk of growth failure and respiratory symptoms at 3 years of age than full-term births, with an inverse dose-response pattern.

    DOI: 10.1136/archdischild-2024-327033

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  • 新生児黄疸に対する光療法と睡眠 子どもの健康と環境に関する全国調査(エコチル調査)より

    堀田 将志, 植田 紀美子, 池原 賢代, 谷川 果菜美, 中山 博文, 和田 和子, 木村 正, 大薗 恵一, 祖父江 友孝, 磯 博康

    日本小児科学会雑誌   128 ( 2 )   220 - 220   2024.2

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  • 新生児黄疸に対する光療法の期間とアレルギー疾患 子どもの健康と環境に関する全国調査(エコチル調査)より

    堀田 将志, 植田 紀美子, 池原 賢代, 谷川 果菜美, 中山 博文, 和田 和子, 木村 正, 大薗 恵一, 祖父江 友孝, 磯 博康

    日本小児科学会雑誌   128 ( 2 )   265 - 265   2024.2

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  • 新生児黄疸に対する光療法と発達遅滞 子どもの健康と環境に関する全国調査(エコチル調査)より

    堀田 将志, 植田 紀美子, 池原 賢代, 谷川 果菜美, 中山 博文, 和田 和子, 木村 正, 大薗 恵一, 祖父江 友孝, 磯 博康

    日本小児科学会雑誌   128 ( 2 )   264 - 264   2024.2

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  • Lesson Learned from Impact of COVID-19 Pandemic on People with Visual Impairment Invited Reviewed

    Kimiko Ueda

    JMA Journal   7 ( 1 )   120 - 121   2024.1

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)   Publisher:Japan Medical Association  

    DOI: 10.31662/jmaj.2023-0193

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  • Higher risk of respiratory infections and otitis media in cleft lip and/or palate patients: the Japan Environment and Children's Study.

    Hiroshi Kurosaka, Takashi Kimura, Jia-Yi Dong, Meishan Cui, Satoyo Ikehara, Kimiko Ueda, Hiroyasu Iso, Takashi Yamashiro

    Environmental health and preventive medicine   29   66 - 66   2024

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    BACKGROUND: Cleft lip and/or palate (CL/P) is one of the most frequent craniofacial disorder which could associate with a wide range of craniofacial complication. In order to perform comprehensive care of CL/P patients, it is crucial to elucidate the link of CL/P and general clinical conditions. This study aims to elucidate the relationships between medical history of different CL/P types and infectious diseases to serve as a reference for the comprehensive care of patients with CL/P. METHODS: We investigated the association between a history different types of CL/P and the risk of infectious diseases among 1-year old children in the Japan Environment and Children's Study (JECS). Among the 104,065 registered fetal records, 92,590 eligible participants were included in the analysis. RESULTS: The multivariable-adjusted risk ratios (95% confidence intervals) for otitis media were increased in cleft lip and palate (CLP) and cleft palate only (CPO) groups by 3.81 (2.73-5.31) and 2.27 (1.22-4.22), respectively. The prevalence of Upper respiratory inflammation (URTI) was not associated with CLP, cleft lip only, or CPO. However, analysis in all groups showed a higher risk of URTI compared with the control group (1.31 [1.04-1.66]). CONCLUSIONS: CL/P care requires additional attention to prevent airway infectious diseases such as URTI before 1 year of age. Further research is warranted to elucidate the relationship between CL/P and general medical conditions.

    DOI: 10.1265/ehpm.24-00150

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  • 子育て世代包括支援センターの認知度と利用状況ーこども家庭センター設置に向けた考察ー Reviewed

    植田紀美子

    厚生の指標   70 ( 13 )   7 - 11   2023.11

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  • Neurodevelopmental outcomes at age 3 years after moderate preterm, late preterm and early term birth: the Japan Environment and Children's Study. Reviewed International journal

    Katsuya Hirata, Kimiko Ueda, Kazuko Wada, Satoyo Ikehara, Kanami Tanigawa, Tadashi Kimura, Keiichi Ozono, Tomotaka Sobue, Hiroyasu Iso

    Archives of disease in childhood. Fetal and neonatal edition   2023.9

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    OBJECTIVE: To assess the association between gestational age classification at birth and the risk of neurodevelopmental impairments at age 3 years. DESIGN: Cohort study using the Japan Environment and Children's Study database. PATIENTS: A total of 86 138 singleton children born without physical abnormalities at 32-41 weeks of gestation enrolled between January 2011 and March 2014. MAIN OUTCOME MEASURES: Neurodevelopmental impairment, evaluated using the Ages and Stages Questionnaire (third edition). METHODS: Logistic regression analysis was used to evaluate the risk of neurodevelopmental impairment in moderate preterm, late preterm and early term children compared with term children after adjusting for socioeconomic and perinatal factors. RESULTS: The respective adjusted ORs (95% CIs) of incidence of scores below the cut-off value (<-2.0 SD) at age 3 years for moderate preterm, late preterm and early term births, compared with full-term births, were as follows: communication, 2.40 (1.54 to 3.73), 1.43 (1.19 to 1.72) and 1.11 (1.01 to 1.21); gross motor, 2.55 (1.69 to 3.85), 1.62 (1.36 to 1.93) and 1.20 (1.10 to 1.30); fine motor, 1.93 (1.34 to 2.78), 1.55 (1.35 to 1.77) and 1.08 (1.01 to 1.15); problem solving, 1.80 (1.22 to 2.68), 1.36 (1.19 to 1.56) and 1.07 (1.00 to 1.14) and personal-social, 2.09 (1.29 to 3.40), 1.32 (1.07 to 1.63) and 1.00 (0.91 to 1.11). CONCLUSION: Moderate preterm, late preterm and early term births were associated with developmental impairment at age 3 years compared with full-term births, with increasing prematurity. Careful follow-up of non-full-term children by paediatricians and other healthcare providers is necessary for early detection of neurodevelopmental impairment and implementation of available intervention.

    DOI: 10.1136/archdischild-2023-325600

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  • Prenatal exposure to selenium, mercury, and manganese during pregnancy and allergic diseases in early childhood: The Japan Environment and Children's study. Reviewed International journal

    Junji Miyazaki, Satoyo Ikehara, Kanami Tanigawa, Takashi Kimura, Kimiko Ueda, Keiichi Ozono, Tadashi Kimura, Yayoi Kobayashi, Shin Yamazaki, Michihiro Kamijima, Tomotaka Sobue, Hiroyasu Iso

    Environment international   179   108123 - 108123   2023.8

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    BACKGROUND: Prenatal exposure to metallic elements may adversely affect early childhood health. However, more evidence is needed as population-based cohort studies are currently limited. OBJECTIVES: We aimed to examine the associations between prenatal metallic (mercury, selenium, and manganese) exposure and the risk of allergic diseases in early childhood until three years of age. METHODS: The data from 94,794 mother-infant pairs, who participated in the Japan Environment and Children's study, were used in this study. Prenatal metallic element exposure was measured in maternal blood collected during mid-pregnancy. The incidence of atopic dermatitis, food allergies, asthma, and allergic rhinitis during the first three years of life was prospectively investigated using self-reports of physician-diagnosed allergies. A multivariable modified Poisson regression model was used to estimate the cumulative incidence ratio and their 95% confidence intervals of allergic diseases associated with prenatal exposure to mercury, selenium, and manganese. We further evaluated the interaction between mercury and selenium exposures in this association. RESULTS: We confirmed 26,238 cases of childhood allergic diseases: atopic dermatitis, food allergies, asthma, and allergic rhinitis in 9,715 (10.3%), 10,897 (11.5%), and 9,857 (10.4%), 4,630 (4.9%), respectively. No association was found between prenatal mercury or manganese exposure and the risk of allergic diseases. Prenatal selenium exposure was inversely associated with atopic dermatitis, food allergies, allergic rhinitis, and any allergic diseases, but not with asthma. These inverse associations were more pronounced for lower mercury exposures than for higher exposures. CONCLUSIONS: Our findings suggest that prenatal exposure to selenium may be beneficial for reducing the risk of atopic dermatitis, food allergies, allergic rhinitis, and any allergic diseases in early childhood, especially with lower prenatal mercury exposure.

    DOI: 10.1016/j.envint.2023.108123

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  • Current situation and perspectives of early childhood intervention in Japan Invited

    8 ( 1 )   4 - 16   2023.6

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    DOI: 10.50870/00000614

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  • Association Between Mode of Delivery and Postpartum Depression: The Japan Environment and Children’s Study (JECS) Reviewed

    Sachiko Baba, Satoyo Ikehara, Ehab S. Eshak, Kimiko Ueda, Tadashi Kimura, Hiroyasu Iso

    Journal of Epidemiology   33 ( 5 )   209 - 216   2023.5

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    Publishing type:Research paper (scientific journal)   Publisher:Japan Epidemiological Association  

    DOI: 10.2188/jea.je20210117

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  • Correction to: Phototherapy and risk of developmental delay: the Japan Environment and Children's Study. International journal

    Masashi Hotta, Kimiko Ueda, Satoyo Ikehara, Kanami Tanigawa, Hirofumi Nakayama, Kazuko Wada, Tadashi Kimura, Keiichi Ozono, Tomotaka Sobue, Hiroyasu Iso

    European journal of pediatrics   182 ( 5 )   2151 - 2153   2023.5

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  • Association between neonatal phototherapy and sleep: The Japan Environment and Children's Study. Reviewed International journal

    Masashi Hotta, Kimiko Ueda, Satoyo Ikehara, Kanami Tanigawa, Hirofumi Nakayama, Kazuko Wada, Tadashi Kimura, Keiichi Ozono, Tomotaka Sobue, Hiroyasu Iso

    Journal of sleep research   32 ( 5 )   e13911   2023.4

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    This observational cohort study aimed to evaluate the association between the duration of neonatal phototherapy and sleep-and-wakefulness states at 1 month, 1.5 years, and 3 years of age. We analysed data from 77,876 infants using the Japan Environment and Children's Study, a nationwide birth cohort study. The participants were divided into three groups: no phototherapy, short phototherapy (1-24 h), and long phototherapy (>24 h). Multiple regression analysis was performed to assess the effect of phototherapy duration on infant sleep at each age after adjusting for potential risk factors. A longer duration of phototherapy was associated with a shorter sleep time over 24 h at 1 month of age (β, -0.62; SE, -0.77 to -0.47) when compared with a shorter duration of, or no, phototherapy, following the adjustment of confounding factors. Contrastingly, the short duration group, when compared with the no phototherapy group, was associated with later sleep onset (β, 0.04; SE, 0.00-0.08) and later sleep offset (β, 0.05; SE, 0.01-0.09) at 1.5 years of age. We concluded that the duration of phototherapy may be transiently associated with sleep duration in infants, as emphasised by the shortening of the total sleep time per 24 h at 1 month of age.

    DOI: 10.1111/jsr.13911

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  • Daily meals in context: A quantitative analysis of elementary school students' drawings Reviewed

    Luna Kinoshita, Aya Goto, Satoko Okabe, Kenichi Satoh, Kaori Honda, Kimiko Ueda, Michio Murakami, Kenneth E. Nollet

    Frontiers in Communication   8   2023.3

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    To investigate school-age children's perspectives on food and nutrition, we pilot tested a method to quantify and analyze crayon drawings collected from students in health education classes at two elementary schools in Fukushima, Japan. Included were 28 students in a mixed class of first and second graders and 26 students in a fourth-grade class. Specific foods, general shapes, and color choices in children's drawings were entered into a spreadsheet and analyzed quantitatively. From first- and second-graders' data, co-occurrence network analysis put meals into three groups: at home, eating out, and lunch boxes. Among fourth graders, co-occurrence network analysis called attention to the cucumber, noteworthy for being a local agricultural product. In addition, students who drew more side dishes also drew more staple foods and main dishes (p = 0.04), used more colors (p = 0.006), and showed satisfaction with their community (p = 0.04). These results suggest that students' understanding of eating was centered on the places where they eat and that they valued regional specialty products. Furthermore, the drawing of side dishes was indicative of a balanced diet, which in turn was associated with higher satisfaction with their community. Our trial indicates that children's drawings can be a useful tool for adults to grasp children's understanding of health-related information in daily living.

    DOI: 10.3389/fcomm.2023.1008108

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  • Phototherapy and risk of developmental delay: the Japan Environment and Children's Study. Reviewed International journal

    Masashi Hotta, Kimiko Ueda, Satoyo Ikehara, Kanami Tanigawa, Hirofumi Nakayama, Kazuko Wada, Tadashi Kimura, Keiichi Ozono, Tomotaka Sobue, Hiroyasu Iso

    European journal of pediatrics   182 ( 5 )   2139 - 2149   2023.2

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    UNLABELLED: This observational cohort study aimed to examine the association between the duration of phototherapy for neonatal jaundice and the risk of developmental delay at 3 years of age using nationwide birth cohort data. Data from 76,897 infants were analyzed. We divided participants into four groups: no phototherapy, short phototherapy (1-24 h), long phototherapy (25-48 h), and very long phototherapy (> 48 h). The Japanese version of the Ages and Stages Questionnaire-3 was used to evaluate the risk of developmental delay at 3 years of age. Logistic regression analysis was performed to assess the impact of phototherapy duration on the prevalence of developmental delay. After adjustment for potential risk factors, a dose-response relationship was identified between the duration of phototherapy and Ages and Stages Questionnaire-3, and the differences were significant in four domains; odds ratio for communication delay was associated with short, long, and very long phototherapy = 1.10 (95% confidence interval 0.97-1.26), 1.32 (1.04-2.66), and 1.48 (1.11-1.98), respectively; for gross motor delay = 1.01 (0.89-1.15), 1.28 (1.03-2.58), and 1.26 (0.96-1.67); for problem solving delay = 1.13 (1.03-1.25), 1.19 (0.99-1.43), and 1.41 (1.11-1.79); and for personal social delay = 1.15 (0.99-1.32), 1.10 (0.84-1.44), and 1.84 (1.38-2.45). CONCLUSION: Longer duration of phototherapy is a predictive factor for developmental delay, making it important to avoid extended periods of phototherapy. However, whether it increases the prevalence of developmental delay remains unclear. WHAT IS KNOWN: • Phototherapy is a common treatment for neonatal jaundice, associated with both short-term and long-term complications. • However, an association between phototherapy and the prevalence of developmental delay has not been revealed in a large cohort study. WHAT IS NEW: • We identified that a long duration of phototherapy was a predictive factor for developmental delay at 3 years of age. • However, whether a long duration of phototherapy increases the prevalence of developmental delay remains unclear.

    DOI: 10.1007/s00431-022-04785-1

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  • コロナ禍におけるオンライン集団外来の取組

    植田 紀美子, 三島 祐子, 池川 敦子, 川本 祥子, 谷村 千嘉子, 南 真希子, 住田 真希, 松田 圭子, 川戸 和美, 西村 夕美子, 長谷川 結子, 西 恵理子, 岡本 伸彦

    日本ダウン症療育研究   ( 16 )   39 - 41   2023.2

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  • 妊娠間隔と早産リスクとの関連 子どもの健康と環境に関する全国調査(エコチル調査) Reviewed

    谷川 果菜美, 池原 賢代, 崔 美善, 川西 陽子, 木村 正, 植田 紀美子, 山岸 良匡, 磯 博康

    Journal of Epidemiology   33 ( Suppl.1 )   146 - 146   2023.2

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    Language:Japanese   Publisher:(一社)日本疫学会  

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  • 妊娠間隔と早産リスクとの関連 子どもの健康と環境に関する全国調査(エコチル調査)

    谷川 果菜美, 池原 賢代, 崔 美善, 川西 陽子, 木村 正, 植田 紀美子, 山岸 良匡, 磯 博康

    Journal of Epidemiology   33 ( Suppl.1 )   146 - 146   2023.2

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  • Self-reported eating habits and dyslipidemia in men aged 20-39 years: the Japan Environment and Children's Study. Reviewed

    Meishan Cui, Satoyo Ikehara, Kimiko Ueda, Kazumasa Yamagishi, Hiroyasu Iso

    Environmental health and preventive medicine   28   41 - 41   2023

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    BACKGROUND AND AIMS: Unhealthy eating behaviors, including eating fast, eating after satiety, skipping breakfast, and eating out are common among men aged 20-39 years. In this cross-sectional study, we aimed to examine the association between self-reported eating habits and the prevalence of dyslipidemia. METHODS: The participants of this study were 38,233 men aged 20-39 years, whose food consumption frequency related information was collected through a questionnaire. Dyslipidemia was defined as total cholesterol (TC) ≥190 mg/dL, fasting triglyceride (TG) ≥150 mg/dL and non-fasting TG ≥175 mg/dL, high-density lipoprotein cholesterol (HDL-C) <40 mg/dL, low-density lipoprotein cholesterol (LDL-C) ≥140 mg/dL. Odds ratios (ORs) and 95% confidence intervals were calculated relative to healthy eating habits using logistic regression, after adjustment for age, study unit, and other potential confounding factors. RESULTS: Moderate and fast speeds were associated with a higher prevalence of reduced HDL-C (by 27% and 26%, respectively) compared to slow speeds. Eating after satiety was associated with a higher prevalence of elevated TC (by 16%) and elevated TG (by 11%), elevated LDL-C (by 21%). Breakfast eating of 1-4 times/week and <1 time/week were associated with a higher prevalence of elevated TC (by 11% and 16%, respectively) and elevated LDL-C (by 21% and 38%, respectively) compared to that of ≥5 times/week. Eating out of ≥5 times/week was associated with a 13% higher prevalence of elevated TG. CONCLUSIONS: All of four unhealthy eating habits were associated with a higher prevalence of dyslipidemia in men aged 20-39 years.

    DOI: 10.1265/ehpm.23-00008

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  • The Duration of Neonatal Phototherapy and Allergic Disorders: The Japan Environment and Children's Study. Reviewed International journal

    Masashi Hotta, Kimiko Ueda, Satoyo Ikehara, Kanami Tanigawa, Hirofumi Nakayama, Kazuko Wada, Tadashi Kimura, Keiichi Ozono, Tomotaka Sobue, Hiroyasu Iso

    International archives of allergy and immunology   184 ( 3 )   1 - 9   2022.12

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    INTRODUCTION: Currently, the association between the duration of neonatal phototherapy and the risk of allergic disorders has not been reported. This observational cohort study aimed to examine the association between allergic disorders, including food allergies, that are present before 3 years of age and the duration of phototherapy using the nationwide birth cohort data. METHODS: The Japan Environment and Children's Study was a nationwide birth cohort study. Data of 77,064 infants aged 1 year, 1.5 years, 2 years, and 3 years were analyzed. We divided the participants into three groups: no phototherapy, short phototherapy (1-24 h), and long phototherapy (>24 h) and evaluated the cumulative incidence of allergic disorders before 3 years of age, including asthma, atopic dermatitis, and food allergies. Logistic regression analysis was performed to assess the impact of phototherapy duration on the cumulative incidence of allergic disorders. RESULTS: After adjustment for potential risk factors, long phototherapy was found to be positively associated with food allergies at age 2 years (OR: 1.16; 95% CI: 1.01-1.33) and all allergic disorders at age 3 years (OR: 1.12; 95% CI: 1.01-1.24), including food allergies (OR 1.18; 95% CI: 1.04-1.35). CONCLUSION: A long duration of neonatal phototherapy was positively associated with the risk of allergic disorders, especially food allergies.

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  • Impact of stage 1 hypertension in the first and second trimesters on adverse pregnancy outcomes: The Japan Environment and Children's study (JECS). Reviewed International journal

    Kanako Ishii, Sachiko Baba, Satoyo Ikehara, Kimiko Ueda, Kazumasa Yamagishi, Tadashi Kimura, Hiroyasu Iso

    Pregnancy hypertension   30   232 - 237   2022.12

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    OBJECTIVES: To investigate the association between stage 1 hypertension, defined as systolic blood pressure (BP) of 130-139 mmHg or diastolic BP of 80-89 mmHg, in the first and second trimesters and the risk of adverse pregnancy outcomes. STUDY DESIGN: We analyzed 79,249 singleton pregnancies from a nationwide birth cohort study. BP in the first and second trimesters was classified into normal, elevated, stage1 hypertension, and stage 2 hypertension. We examined the risk of adverse pregnancy outcomes in each group using multivariable logistic regression analysis. We also investigated the influence of BP changes between the first and second trimesters on adverse pregnancy outcomes. MAIN OUTCOME MEASURES: Overall preterm birth (PTB < 37 weeks), early PTB (<34 weeks), and small for gestational age (SGA). RESULTS: Stage 1 hypertension in the first trimester was associated with increased risks of overall PTB (aOR, 1.23; 95 %CI, 1.08-1.39), early PTB (aOR, 1.38; 95 %CI, 1.07-1.79), and SGA (aOR, 1.19; 95 %CI, 1.04-1.36) compared to normal BP. These risks were more evident in the second trimester; overall PTB (aOR, 1.87; 95 %CI, 1.64-2.14), early PTB (aOR, 2.21; 95 %CI, 1.69-2.87), and SGA (aOR, 1.38; 95 %CI, 1.18-1.62). The risk of PTB was higher among women with an upward BP trajectory between the first and second trimesters. CONCLUSIONS: Stage 1 hypertension in the first and second trimesters was associated with increased risks of overall PTB, early PTB, and SGA. Monitoring the BP trajectory for stage 1 hypertension may be useful for identifying high-risk groups.

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  • Pregnancy outcomes after preterm premature rupture of membranes: The Japan Environment and Children's Study. Reviewed International journal

    Katsuya Hirata, Kimiko Ueda, Kazuko Wada, Satoyo Ikehara, Kanami Tanigawa, Tadashi Kimura, Keiichi Ozono, Hiroyasu Iso

    The journal of obstetrics and gynaecology research   48 ( 11 )   2756 - 2765   2022.11

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    AIM: To evaluate the pregnancy outcomes of preterm premature rupture of membranes (preterm PROM; PPROM) by gestational age. METHODS: This cohort study analyzed data from the Japan Environment and Children's Study. Pregnancy outcomes were documented using descriptive statistics. Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of complications. RESULTS: Data were collected for 104 062 fetuses, and 99 776 were eligible for inclusion. The incidences of early (18-23 weeks) and late (24-36 weeks) PPROM were 0.1% (n = 102) and 1.2% (n = 1205), respectively. Of the 1307 cases, 66 (5.0%) resulted in miscarriage or stillbirth. Overall, 85.6% (1119/1307) resulted in preterm births, and 9.3% (122/1307) in term births. There was a higher incidence of oligohydramnios (OR 6.82, 95% CI 4.07, 11.4; OR 2.42, 95% CI 1.72, 3.40), intrauterine infection (OR 11.9, 95% CI 7.06, 19.9; OR 4.39, 95% CI 3.01, 6.41), cesarean delivery (OR 3.31, 95% CI 2.32, 4.71; OR 1.34, 95% CI 0.97, 1.85), placental abruption (OR 5.57, 95% CI 2.30, 13.5; OR 5.40, 95% CI 3.58, 8.14), and 5-min Apgar score <7 (OR 35.3, 95% CI 21.5, 57.9; OR 2.66, 95% CI 1.75, 4.05) for early and late, compared to no, PPROM, respectively. Miscarriage or stillbirth was higher in early (OR 5.84, 95% CI 3.72, 9.15) and lower in late (OR 0.21, 95% CI 0.06, 0.68) compared to those without PPROM. CONCLUSIONS: This study described the epidemiology of pregnancy outcomes of early (occurring at the limit of viability) and late PPROM.

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  • Association between gestational weight gain and risk of overweight at 3 years old: The Japan Environment and Children's Study. Reviewed International journal

    Kanami Tanigawa, Yoko Kawanishi, Satoyo Ikehara, Takashi Kimura, Kimiko Ueda, Tadashi Kimura, Keiichi Ozono, Hiroyasu Iso

    Pediatric obesity   18 ( 1 )   e12978   2022.9

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    BACKGROUND: It is unclear if gestational weight gain (GWG) increases the risk of children with overweight. OBJECTIVES: We examined the association between GWG and the risk of overweight in 3-year-old children in the Japanese nationwide birth cohort study. METHODS: Among 64 336 singleton births, we calculated the risk ratios (RRs) and 95% confidence intervals (95% CIs) of the association between GWG categories and children with overweight, following an adjustment of the confounding variables. RESULTS: GWG was positively associated with the risk of overweight among 3-year-old children. The multivariable RR (95% CI) was 1.21 (1.17-1.25) per 5 kg increase of the GWG. The multivariable RR (95% CI) for excessive GWG was 1.20 (1.12-1.28) and 1.27 (1.16-1.39) based on the modified Japanese and IOM criteria, respectively, compared to adequate GWG. The multivariable RR (95% CI) of overweight with children for inadequate versus adequate GWG was 0.83 (0.78-0.88) and 0.84 (0.79-0.89) based on the modified Japanese and IOM criteria, respectively. CONCLUSIONS: GWG was positively associated with a high risk of overweight at 3 years of age. The risk of offspring overweight was 20%-27% higher and 16%-17% lower with excessive GWG and inadequate GWG, respectively, compared to adequate GWG, based on the aforementioned criteria.

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  • Long-term outcomes of children with neonatal transfer: the Japan Environment and Children's Study. Reviewed International journal

    Katsuya Hirata, Kimiko Ueda, Kazuko Wada, Satoyo Ikehara, Kanami Tanigawa, Tadashi Kimura, Keiichi Ozono, Hiroyasu Iso

    European journal of pediatrics   181 ( 6 )   2501 - 2511   2022.3

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    This study aimed to evaluate the association of neonatal transfer with the risk of neurodevelopmental outcomes at 3 years of age. Data were obtained from the Japan Environment and Children's Study. A general population of 103,060 pregnancies with 104,062 fetuses was enrolled in the study in 15 Regional Centers between January 2011 and March 2014. Live-born singletons at various gestational ages, including term infants, without congenital anomalies who were followed up until 3 years were included. Neurodevelopmental impairment was assessed using the Ages and Stages Questionnaire, third edition (ASQ-3) at 3 years of age. Logistic regression was used to estimate the adjusted risk and 95% confidence interval (CI) for newborns with neonatal transfer. Socioeconomic and perinatal factors were included as potential confounders in the analysis. Among 83,855 live-born singletons without congenital anomalies, 65,710 children were studied. Among them, 2780 (4.2%) were transferred in the neonatal period. After adjustment for potential confounders, the incidence of neurodevelopmental impairment (scores below the cut-off value of all 5 domains in the ASQ-3) was higher in children with neonatal transfer compared with those without neonatal transfer (communication: 6.5% vs 3.5%, OR 1.42, 95% CI 1.19-1.70; gross motor: 7.6% vs 4.0%, OR 1.26, 95% CI 1.07-1.49; fine motor: 11.3% vs 7.1%, OR 1.19, 95% CI 1.03-1.36; problem solving: 10.8% vs 6.8%, OR 1.29, 95% CI 1.12-1.48; and personal-social: 6.2% vs 2.9%, OR 1.52, 95% CI 1.26-1.83).   Conclusion: Neonatal transfer was associated with a higher risk of neurodevelopmental impairment at 3 years of age. What is Known: • Neonatal transfer after birth in preterm infants is associated with adverse short-term outcomes. • Long-term outcomes of outborn infants with neonatal transfer in the general population remain unclear. What is New: • This study suggests that neonatal transfer at birth is associated with an increased risk of neurodevelopmental impairment. • Efforts for referring high-risk pregnant women to higher level centers may reduce the incidence of neonatal transfer, leading to improved neurological outcomes in the general population.

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  • The novel and recurrent variants in exon 31 of CREBBP in Japanese patients with Menke-Hennekam syndrome. Reviewed International journal

    Eriko Nishi, Toshiki Takenouchi, Fuyuki Miya, Tomoko Uehara, Kumiko Yanagi, Yuiko Hasegawa, Kimiko Ueda, Seiji Mizuno, Tadashi Kaname, Kenjiro Kosaki, Nobuhiko Okamoto

    American journal of medical genetics. Part A   188 ( 2 )   446 - 453   2022.2

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    Menke-Hennekam syndrome-1 (MKHK1) is a congenital disorder caused by the heterozygous variants in exon 30 or 31 of CREBBP (CREB binding protein) gene mapped on 16p13.3. It is characterized by psychomotor delay, variable impairment of intellectual disability (ID), feeding difficulty, autistic behavior, hearing impairment, short stature, microcephaly, and facial dysmorphisms. The CREBBP loss-of-function variants cause Rubinstein-Taybi syndrome-1 (RSTS1). The function of CREBBP leading to MKHK1 has not been clarified so far, and the phenotype of MKHK1 significantly differs from that of RSTS1. We examined six patients with de novo pathogenic variants affecting the last exon of CREBBP, and they shared the clinical features of MKHK1. This study revealed that one frameshift and three nonsense variants of CREBBP cause MKHK1, and inferred that the nonsense variants of the last exon could further help in the elucidation of the etiology of MKHK1.

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  • A Japanese adult and two girls with NEDMIAL caused by de novo missense variants in DHX30 Reviewed International journal

    Kimiko Ueda, Atsushi Araki, Atsushi Fujita, Naomichi Matsumoto, Tomoko Uehara, Hisato Suzuki, Toshiki Takenouchi, Kenjiro Kosaki, Nobuhiko Okamoto

    Human Genome Variation   8 ( 1 )   24 - 24   2021.12

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    <title>Abstract</title>Lessel et al. reported a novel neurodevelopmental disorder with severe motor impairment and absent language (NEDMIAL) in 12 individuals and identified six different de novo heterozygous missense variants in <italic>DHX30</italic>. The other clinical features included muscular hypotonia, feeding difficulties, brain anomalies, autistic features, sleep disturbances, and joint hypermobility. We report a Japanese adult with a novel missense variant and two girls with de novo missense variants in <italic>DHX30</italic>.

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  • An Inclusive Early Childhood Intervention Program for Children With Disabilities: Possible Effects on Children and Nursery Teachers Reviewed

    Kimiko Ueda, Aya Goto, Toshikazu Imamoto, Yoshihisa Yamazaki

    Frontiers in Rehabilitation Sciences   2   2021.10

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    Inclusive early childhood intervention provides opportunities for children with disabilities to receive education with typically developing children. The present study examined the effects of the AI-AI STEP Program, which is designed to help nursery teachers learn the methods of inclusive early childhood intervention for children with disabilities. This study involved 37 managers of 37 nursery schools in Japan, 48 nursery teachers, and 48 children with disabilities. The school managers, who had previously learned about the program through a seminar we offered, provided the nursery teachers with guidance on the program. The guidance provided to the nursery teachers consisted of combined structured explanations with a manual and on-the-job training. The program was performed for 6 months, and changes in the children's development and behavior and the school nursery teachers' self-efficacy and state-trait anxiety, were examined before and after using the program. Multivariate analysis was used to assess factors that had an effect on the children's developmental gains through the program. The developmental quotient of children significantly improved. In addition, “emotional symptoms” and “peer problems” on the Strengths and Difficulties Questionnaire subscale markedly improved. The self-efficacy of nursery teachers significantly improved, and state anxiety decreased. There was a significant relationship between the improvement of the children's development quotient and a lower development quotient at baseline. The provision of inclusive early childhood intervention using the program promoted the children's development, and improved their behavior. Furthermore, it had a positive effect on the nursery teachers.

    DOI: 10.3389/fresc.2021.759932

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  • 歌舞伎症候群の臨床症状と顎顔面形態について Reviewed

    上松 節子, 山西 整, 植田 紀美子, 大西 有理[山元], 井上 直子, 藤林 えみ, 桐越 晶子, 大槻 浩一, 岡本 伸彦

    大阪母子医療センター雑誌   37 ( 1 )   22 - 30   2021.10

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  • 児童相談所における―保健師の専門性と専門職との協働の実態とあり方児童福祉司と児童心理司への調査から Reviewed

    仁木敦子,杉山真理子, 伊永真季, 林美恵子, 江口 晋, 植田紀美子

    保健師ジャーナル   77 ( 6 )   2021.6

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  • Clinical spectrum of individuals with de novo EBF3 variants or deletions Reviewed International journal

    Eriko Nishi, Tomoko Uehara, Kumiko Yanagi, Yuiko Hasegawa, Kimiko Ueda, Tadashi Kaname, Toshiyuki Yamamoto, Kenjiro Kosaki, Nobuhiko Okamoto

    American Journal of Medical Genetics Part A   185 ( 10 )   2913 - 2921   2021.5

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    Hypotonia, ataxia and delayed development syndrome (HADDS) (MIM#617330) is a neurodevelopmental disorder caused by heterozygous pathogenic variants in EBF3 (MIM; 607,407), which is located on chromosome 10q26, and was first reported in 2017. To date, missense, nonsense and frameshift variants have been reported as causes of HADDS, and EBF3 pathogenic variants have been predicted to result in nonsense-mediated mRNA decay and haploinsufficiency. It was also reported that total deletion of EBF3 associated with a 10q26.3 microdeletion also causes HADDS symptoms, supporting the concept that HADDS results from haploinsufficiency of EBF3. Here, we report eight unrelated individuals with heterozygous pathogenic variants of EBF3 or haploinsufficiency of EBF3 due to 10q26 deletion, who exhibit clinical findings including craniofacial features of HADDS. In a detailed examination of clinical manifestations in this study, revealed that neurogenic bladder was diagnosed in infancy (the median 6.5 months), was more frequent than previously reported, and required cystostomy in all but one case. For psychomotor delay, it was also found that their motor/skills values were significantly lower than their cognition/adaptation values (p = 0.0016; paired t-test). Therefore, that HADDS is a recognizable syndrome that shares its characteristic facial features, and that neurogenic bladder diagnosed in infancy and psychomotor delay with marked delay in motor/skills are noteworthy findings in the diagnosis and management of individuals with HADDS.

    DOI: 10.1002/ajmg.a.62369

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  • Blended phenotype of combination of HERC2 and AP3B2 deficiency and Angelman syndrome caused by paternal isodisomy of chromosome 15 Reviewed International journal

    Kimiko Ueda, Satoru Ogawa, Keiko Matsuda, Yuiko Hasegawa, Eriko Nishi, Kumiko Yanagi, Tadashi Kaname, Toshiyuki Yamamoto, Nobuhiko Okamoto

    American Journal of Medical Genetics Part A   185 ( 10 )   3092 - 3098   2021.5

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    Angelman syndrome is a neurodevelopmental disorder characterized by intellectual disability (ID), a distinctive gait pattern, abnormal behaviors, severe impairment in language development, and characteristic facial features. Most cases are caused by the absence of a maternal contribution to the imprinted region on chromosome 15q11-q13. Here, we present the first reported case of a 3-year-old boy with an atypical phenotype of Angelman syndrome due to uniparental isodisomy with two recessive homozygous pathogenic variants: in HERC2 and AP3B2. Known phenotypes related to HERC2 and AP3B2 include ID and early infantile epileptic encephalopathy, respectively. The patient had severe global developmental delay and profound ID and showed a happy demeanor, stereotypic laughter, and hand-flapping movements, but also irritability. Craniofacial dysmorphic features, including brachycephaly, strabismus, wide ala nasi, short philtrum, wide open mouth, and slight hypopigmentation were seen. Progressive microcephaly was noted. Magnetic resonance imaging of the brain showed delayed myelination and cerebral atrophy. Trio whole exome sequencing and CGH-SNP array analysis revealed paternal uniparental isodisomy of chromosome 15 and two coexisting recessive diseases resulting from homozygous HERC2 and AP3B2 pathogenic variants. The pathogenic variant in HERC2 was inherited from his heterozygous-carrier father, and the variant in AP3B2 was de novo. We suppose that these unusual features were the combination of the effect of three concomitant disorders.

    DOI: 10.1002/ajmg.a.62371

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  • Association between interpregnancy interval and risk of preterm birth and its modification by folate intake: the Japan Environment and Children's Study. Reviewed

    Kanami Tanigawa, Satoyo Ikehara, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Kazumasa Yamagishi, Hiroyasu Iso

    Journal of epidemiology   2021.5

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    BACKGROUND: Both short and long interpregnancy intervals (IPIs) have been associated with risk of preterm birth, but the evidence is limited in Asians. It is also uncertain whether the association is modified by dietary folate intake or folic acid supplementation during pregnancy. Thus, we examined associations between IPI and risk of preterm birth, and effect modification of those associations by dietary intake of folate and supplementation with folic acid on the basis of a nationwide birth cohort study. METHODS: Among 103,062 pregnancies registered in the Japan Environment and Children's Study, 55,203 singleton live-birth pregnancies were included in the analysis. We calculated IPI using birth date, gestational age at birth of offspring, and birth data of the latest offspring. Odds ratios (ORs) and 95% confidence intervals (CIs) of the risk of preterm birth were estimated according to IPI categories. RESULTS: Both <6-month and ≥120-month IPIs were associated with an increased risk of preterm birth, compared with an 18-23-month IPI. The multivariable ORs were 1.63 (95% CI, 1.30-2.04) for <6-month and 1.41 (95% CI, 1.11-1.79) for ≥120-month IPIs. These associations were confined to women with inadequate intake of dietary folate and folic acid supplementation during pregnancy. Multivariable ORs were 1.76 (95% CI, 1.35-2.29) for <6-month IPI and 1.65 (95% CI, 1.24-2.19) for ≥120-month IPI. CONCLUSION: Both <6-month and ≥120-month IPIs were associated with an increased risk of preterm birth. These higher risks were confined to women with inadequate intake of dietary folate and folic acid supplementation during pregnancy.

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  • 児童発達支援ガイドラインが推奨する発達支援内容に関する全国実態調査 Reviewed

    植田紀美子

    厚生の指標   68 ( 5 )   4 - 13   2021.5

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  • Soy Consumption and Incidence of Gestational Diabetes Mellitus: The Japan Environment and Children's Study Reviewed International journal

    Jia-Yi Dong, Takashi Kimura, Satoyo Ikehara, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Hiroyasu Iso

    Eur J Nutr.   2020.6

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    BACKGROUND: Intervention studies have shown that isoflavone treatment improved glucose metabolism, indicating that soy intake may have a potential role in diabetes prevention. OBJECTIVES: We aimed to investigate the prospective association of soy isoflavone and soy food intakes with incidence of gestational diabetes mellitus (GDM) in a birth cohort study. METHODS: We recruited 97,454 pregnant women (median gestational age 12 weeks) between January 2011 and March 2014. Dietary intakes during the 12 months preceding study enrollment were assessed by a semi-quantitative food frequency questionnaire. The relative risks of GDM associated with soy isoflavone and soy food intakes were obtained by Poisson regression. Demographic information, histories of diseases, socioeconomic status, lifestyles, and dietary habits, obtained by a self-administrated questionnaire, were used for covariate adjustments. RESULTS: We identified 1904 cases of GDM (2.2%) among 84,948 women. Compared with those in the lowest quintile of soy isoflavone intake, women in the highest quintile were found to have experienced a significantly lower risk of GDM (multivariate relative risk = 0.82; 95% confidence interval: 0.70, 0.95; P for trend = 0.05). Similar results were observed for genistein and daidzein. Regarding soy foods, intakes of miso soup and natto were inversely associated with GDM incidence (both P for trend ≤ 0.01), whereas the association for tofu intake appeared to be nonlinear (P for trend = 0.74). CONCLUSIONS: Higher intakes of miso soup and natto before and during early pregnancy, compared with lower intakes, may be associated with a lower incidence of GDM.

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  • Self-Reported Eating Speed and Incidence of Gestational Diabetes Mellitus: the Japan Environment and Children's Study. Reviewed International journal

    Jia-Yi Dong, Satoyo Ikehara, Takashi Kimura, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Hiroyasu Iso, The Japan Environment And Children's Study Group

    Nutrients   12 ( 5 )   2020.5

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    There is little evidence linking eating speed to gestational diabetes mellitus (GDM) incidence. We therefore aimed to evaluate the prospective association of eating speed with GDM incidence. Overall, 97,454 pregnant women were recruited between January 2011 and March 2014. Singleton pregnant women who did not have GDM, heart disease, stroke, cancer, type 1 diabetes, and/or type 2 diabetes at the time of study enrollment were eligible. Each woman was asked about her eating speed at that time via a questionnaire. Odds ratios of GDM in relation to eating speed were obtained using logistic regression. Among the 84,811 women eligible for analysis, 1902 cases of GDM were identified in medical records. Compared with women who reported slow eating speed, the age-adjusted odds ratios (95% confidence interval) of GDM for women who reported medium, relatively fast, or very fast eating speed were 1.03 (0.90, 1.18), 1.07 (0.94, 1.23), and 1.28 (1.05, 1.58), respectively. Adjustment for demographic, lifestyle-related, and dietary factors including dietary fat, dietary fiber, and energy intakes yielded similar results. The association was attenuated and no longer significant after further adjustment for pre-pregnancy body mass index. The mediation analysis showed that being overweight accounted for 64% of the excess risk of GDM associated with eating speed. In conclusion, women who reported very fast eating speed, compared with those reporting slow eating speed, were associated with an increased incidence of GDM, which may be largely mediated by increased body fat.

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  • Skipping breakfast before and during early pregnancy and incidence of gestational diabetes mellitus: the Japan Environment and Children's Study. Reviewed International journal

    Jia-Yi Dong, Satoyo Ikehara, Takashi Kimura, Meishan Cui, Yoko Kawanishi, Tadashi Kimura, Kimiko Ueda, Hiroyasu Iso

    The American journal of clinical nutrition   111 ( 4 )   829 - 834   2020.4

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    BACKGROUND: There is little evidence linking breakfast skipping to the incidence of gestational diabetes mellitus (GDM). OBJECTIVES: We aimed to evaluate the prospective association of breakfast consumption with the incidence of GDM. METHODS: A total of 103,099 pregnancies were registered during study enrollment (January 2011 to March 2014), involving 97,454 pregnant women from 15 areas across Japan. Singleton pregnant women free of GDM, stroke, heart disease, cancer, and type 1 or type 2 diabetes at the study enrollment were eligible for analysis. We used a self-administered questionnaire to obtain data on demographic information, socioeconomic status, self-rated health status, disease history, lifestyle, and dietary habits of each woman at study enrollment. A semiquantitative FFQ was used for dietary assessment. We used logistic regression to obtain the OR of GDM in relation to breakfast consumption. RESULTS: Among 84,669 pregnant women for analysis, 1935 cases of GDM were documented. After adjustment for potential confounding factors including prepregnancy BMI, the multivariable-adjusted ORs of GDM for women who consumed breakfast 5-6 times/wk, 3-4 times/wk, and 0-2 times/wk were 1.09 (95% CI: 0.93, 1.27), 1.14 (95% CI: 0.96, 1.34), and 1.21 (95% CI: 1.05, 1.41), respectively, compared with daily breakfast eaters. The association appeared to be dose dependent (P-trend = 0.006) and was not significantly modified by prepregnancy BMI. CONCLUSIONS: Breakfast consumption <3 times/wk before and during early pregnancy, compared with daily consumption, was associated with an increased odds of developing GDM.

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  • Prenatal tobacco smoking is associated with postpartum depression in Japanese pregnant women: The japan environment and children's study. Reviewed International journal

    Meishan Cui, Takashi Kimura, Satoyo Ikehara, Jia-Yi Dong, Kimiko Ueda, Yoko Kawanishi, Tadashi Kimura, Hiroyasu Iso

    Journal of affective disorders   264   76 - 81   2020.3

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    INTRODUCTION: Previous studies in Western countries have examined the association between prenatal smoking and risk for Postpartum depression (PPD). However, evidence from Japan is lacking, despite the high prevalence of smoking among pregnant women. Therefore, we examined the association between prenatal smoking and PPD among pregnant Japanese women. METHODS: We analyzed data for up to 1 month after childbirth from the Japan Environment and Children's Study (JECS), a nationwide birth cohort study. Among the 103,070 pregnant women recruited, 80,872 eligible participants were included in the analysis. PPD was defined as a score of ≥9 on the Edinburgh Postnatal Depression Scale (EPDS). Prenatal smoking and length of smoking cessation among ex-smokers were obtained using self-administered questionnaires at second/third trimester. RESULTS: Among 80,872 pregnant women, 9.0% reported PPD. Multivariable-adjusted odds ratios (OR) (95% confidence intervals) for PPD (reference: never smoked) were 1.24 (1.12-1.37) for women who quit smoking after becoming pregnant, and 1.38 (1.21-1.56) for those who smoked during pregnancy. Compared with women who had never smoked, those who quit smoking ≤5 years before childbirth had a higher occurrence of PPD, with a multivariable-adjusted OR of 1.10 (1.00-1.22). LIMITATIONS: Questionnaire data was self-reported by participants, thus smoking status might be under-reported. CONCLUSIONS: Women who smoked during pregnancy, quit smoking after becoming pregnant, and quit smoking ≤5 years before childbirth are more likely to experience PPD than those who had never smoked.

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  • Associations Between Broader Autism Phenotype and Dietary Intake: A Cross-Sectional Study (Japan Environment & Children's Study). Reviewed International journal

    Kumi Hirokawa, Takashi Kimura, Satoyo Ikehara, Kaori Honjo, Kimiko Ueda, Takuyo Sato, Hiroyasu Iso

    Journal of autism and developmental disorders   50 ( 8 )   2698 - 2709   2020.1

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    The purpose of the present study was to investigate associations of dietary intake including vitamin D, folate, and n-3 and n-6 polyunsaturated fatty acids (PUFA) in pregnant women with broad autism phenotype (BAP). The Japan Environment and Children's Study is a government-funded birth cohort study. All complete data of 92,011 were analyzed. The Japanese version of the Autism Spectrum Quotient was used to assess mothers' BAP level, and a food frequency questionnaire was used to estimate their dietary intake. Mothers with BAP consumed less vegetables, fruits, and fish and shellfish, and they consumed lower folate, vitamin C, vitamin D, and n-3 PUFA than their counterparts. Dietary intervention should be considered for pregnant women with high BAP scores.

    DOI: 10.1007/s10803-020-04380-z

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  • Impacts of early intervention on family outcomes: A multicenter cross-sectional study in Japan. Reviewed International journal

    Kimiko Ueda, Naohiro Yonemoto

    Disability and health journal   13 ( 1 )   100832 - 100832   2020.1

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    BACKGROUND: Recently, the concept of "family-centered" practice was integrated into early intervention programs in Japan. Services provided through early intervention can result in beneficial family outcomes. We previously validated the Family Outcomes Survey-Revised (FOS-R) for use in Japan, but the impact on families was not evaluated. OBJECTIVES: To evaluate potential impacts of early intervention on family outcomes and factors associated with outcome attainment. METHOD: An anonymous, self-administered questionnaire was given to mothers of pre-school-age children with disabilities who were currently receiving early intervention at one of 12 development support centers across Japan. We evaluated scores of the Japanese version of the FOS-R using multivariable random effect models. RESULTS: Data from a total of 394 mothers were analyzed. Longer duration of early intervention was positively associated with family outcomes (<12 mo vs. 12-23 mo; coefficient = 0.19, p = .02, 95% CI: 0.02, 0.36). Perceived helpfulness of early intervention was significantly associated with family outcomes (coefficient = 0.49, p < .001, 95% CI: 0.42, 0.55). CONCLUSIONS: This study suggests that early intervention is associated with better outcomes for families, especially for families who perceive early intervention as helpful.

    DOI: 10.1016/j.dhjo.2019.100832

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  • Chocolate consumption and risk of gestational diabetes mellitus: the Japan Environment and Children's Study. Reviewed International journal

    Jia-Yi Dong, Takashi Kimura, Satoyo Ikehara, Meishan Cui, Yoko Kawanishi, Kazumasa Yamagishi, Kimiko Ueda, Hiroyasu Iso

    The British journal of nutrition   122 ( 8 )   936 - 941   2019.10

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    The association of chocolate consumption with risk of gestational diabetes has not been examined. We aimed to investigate the prospective association between chocolate consumption and risk of gestational diabetes in a large birth cohort in Japan. A total of 97 454 pregnant women with a median gestational age of 12 weeks were recruited from January 2011 to March 2014. Data on demographic information, disease history, socio-economic status, lifestyle and dietary habits were obtained at the study enrolment. Dietary intake during the past 12 months before study enrolment was assessed through a semi-quantitative FFQ. The logistic regression was used to obtain the OR of gestational diabetes in relation to chocolate consumption. Among 84 948 women eligible for the analysis, 1904 cases of gestational diabetes (2·2 %) were identified during the period of pregnancy. After controlling for potential confounding factors including age, smoking status, drinking status, education level, occupation, pre-pregnant BMI, depression, previous history of macrosomia babies, parity, physical activity and dietary factors, women in the highest quartile of chocolate consumption, compared with those in the lowest quartile, had a significantly lower risk of developing gestational diabetes (OR 0·78, 95 % CI 0·67, 0·90; P for trend = 0·002). Stratified analyses suggested that the association was not significantly modified by pre-pregnancy BMI, age, parity, smoking status or drinking status. The present prospective cohort study provided evidence that chocolate consumption was associated with a significant lower risk of gestational diabetes in Japanese women.

    DOI: 10.1017/S0007114519001806

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  • A novel mutation in the GATAD2B gene associated with severe intellectual disability. Reviewed International journal

    Kimiko Ueda, Kumiko Yanagi, Tadashi Kaname, Nobuhiko Okamoto

    Brain & development   41 ( 3 )   276 - 279   2019.3

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    BACKGROUND: The human GATA zinc finger domain containing 2B (GATAD2B) encodes a subunit of the MeCP1-Mi-2/nucleosome remodeling and deacetylase complex, which is involved in chromatin modification and transcription. Recently, patients with severe intellectual disabilities and characteristic features associated with GATAD2B mutations have been identified. CASE REPORT: The patient was a 4-year-old male with dysmorphic features, including frontal bossing, hypertelorism, epicanthal folds, down-slanting palpebral fissures, a flat nasal bridge, a high arched palate, and micrognathia. He spoke no meaningful words and exhibited severe intellectual disability. Hypermetropic astigmatism and mild spasticity of the lower extremities were noted. Whole-exome sequencing revealed a de novo missense mutation in GATAD2B (NM_020699:exon4:c.502C>T; p.(Glu168∗)). CONCLUSION: We report a novel GATAD2B mutation in a boy exhibiting bilateral leg spasticity and white matter abnormalities on brain magnetic resonance imaging.

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  • Associations between broader autism phenotype (BAP) and maternal attachment are moderated by maternal postpartum depression when infants are one month old: A prospective study of the Japan environment & children's study. Reviewed International journal

    Kumi Hirokawa, Takashi Kimura, Satoyo Ikehara, Kaori Honjo, Takuyo Sato, Kimiko Ueda, Hiroyasu Iso

    Journal of affective disorders   243   485 - 493   2019.1

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    BACKGROUND: Broader autism phenotype (BAP) refers to the expression of behavioral and cognitive dispositions similar to autism spectrum disorder. The present study investigated whether mothers' BAP was prospectively associated with maternal attachment, and if postpartum depression modified this association. METHODS: The Japan Environment and Children's Study (JECS) is a national and government-funded birth cohort study that began in January 2011. Among the 103,099 mothers enrolled, 87,369 mothers without a history of depression were included in the analysis. Self-administered questionnaires were used. These included: the Japanese version of the Autism Spectrum Quotient, the Mother to Infant Bonding Scale, and the Edinburgh Postnatal Depression Scale. Logistic regression analyses were performed. RESULTS: The BAP during the second or third trimester of pregnancy was linearly associated with an increased risk of postpartum depression and insecure maternal attachment when infants were one month old (p for trend < 0.001), after adjusting for confounding variables. When stratified by postpartum depression, among the BAP subscales, deficiencies in social skills and communication were associated with an increased risk of insecure maternal attachment in mothers without postpartum depression. The relationships between the BAP subscales and maternal attachment were attenuated among mothers with postpartum depression. LIMITATIONS: Only five items of the Mother to Infant Bonding Scale were used in the present study, and thus the results should be interpreted with caution. CONCLUSIONS: Mothers' BAP was predictive of insecure maternal attachment toward their infant. Postpartum depression partially moderated the associations between mothers' BAP and insecure maternal attachment.

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  • 児童発達支援センターおよび児童発達支援事業所における事故防止対策の現状 Reviewed

    植田 紀美子, 米本 直裕, 山根 希代子

    脳と発達   50 ( 4 )   295 - 297   2018.7

  • Down症候群をもつ乳児とその家族に対する集団外来の取り組み Reviewed

    植田 紀美子, 惠谷 ゆり, 井上 雅美, 青木 寿明, 萱谷 太, 岡本 伸彦

    日本小児科学会雑誌   121 ( 11 )   1872 - 1878   2017.11

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  • Craniosynostosis in patients with RASopathies: Accumulating clinical evidence for expanding the phenotype. Reviewed International journal

    Kimiko Ueda, Masako Yaoita, Tetsuya Niihori, Yoko Aoki, Nobuhiko Okamoto

    American journal of medical genetics. Part A   173 ( 9 )   2346 - 2352   2017.9

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    RASopathies are phenotypically overlapping genetic disorders caused by dysregulation of the RAS/mitogen-activated protein kinase (MAPK) signaling pathway. RASopathies include Noonan syndrome, cardio-facio-cutaneous (CFC) syndrome, Costello syndrome, Neurofibromatosis type 1, Legius syndrome, Noonan syndrome with multiple lentigines, Noonan-like syndrome, hereditary gingival fibromatosis, and capillary malformation/arteriovenous malformation syndrome. Recently, six patients with craniosynostosis and Noonan syndrome involving KRAS mutations were described in a review, and a patient with craniosynostosis and Noonan syndrome involving a SHOC2 mutation has also been reported. Here, we describe patients with craniosynostosis and Noonan syndrome due to de novo mutations in PTPN11 and patients with craniosynostosis and CFC syndrome due to de novo mutations in BRAF or KRAS. All of these patients had cranial deformities in addition to the typical phenotypes of CFC syndrome and Noonan syndrome. In RASopathy, patients with cranial deformities, further assessments may be necessary to look for craniosynostosis. Future studies should attempt to elucidate the pathogenic mechanism responsible for craniosynostosis mediated by the RAS/MAPK signaling pathway.

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  • 療育サービスの子どもと家族への効果の評価に関する全国実態調査 Reviewed

    植田 紀美子, 米本 直裕

    厚生の指標   63 ( 11 )   17 - 22   2016.9

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  • 障害児の育ちにおける保育所の役割 インタビュー調査法による検討 Reviewed

    植田 紀美子, 後藤 あや, 山崎 嘉久

    小児保健研究   75 ( 3 )   398 - 405   2016.5

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  • なぜ、障害児者が”より”高い価値のある社会的役割をになうべきなのか Invited Reviewed

    植田紀美子

    633   1 - 1   2015.9

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  • Eight patients with Williams syndrome and craniosynostosis Reviewed

    Kimiko Ueda, Junji Yamada, Osamu Takemoto, Nobuhiko Okamoto

    EUROPEAN JOURNAL OF MEDICAL GENETICS   58 ( 6-7 )   355 - 357   2015.6

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    DOI: 10.1016/j.ejmg.2015.05.002

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  • Psychometric validation of the Family Outcomes Survey-Revised in Japan. Reviewed International journal

    Kimiko Ueda, Naohiro Yonemoto, Donald B Bailey Jr

    Research in developmental disabilities   39   55 - 66   2015.4

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    According to a revision of Japan's Basic Law for Persons with Disabilities in 2011, Article 17 stipulated the government's obligation to provide early intervention to children with disabilities. However, the concept of family outcomes in early intervention has not really been considered in Japan yet. This article describes the development and validation of the Japanese version of the Family Outcomes Survey Revised (FOS-R). Our goal was to determine whether this survey for assessing how families of children with disabilities are affected by early intervention would be appropriate for use in early intervention in Japan. Both the Japanese version of the FOS-R and an anonymous, self-administered questionnaire about background factors were given to 394 mothers of children who were either currently using or had in the past year used early intervention at an early intervention facility or medical institution. Survey responses were obtained from 335 mothers (response rate of 85.0%). The total number of subjects in the analysis was 301 mothers who answered the Japanese version of the FOS-R completely. To assess content validity, another survey was given to 115 experts involved in supporting children with disabilities and their families. The family outcomes indicator items as well as the helpfulness indicators items showed good psychometric properties. Although the components of the FOS-R worked better as individual subscales than as a single scale, we confirmed that a total score was also psychometrically valid. We also confirmed both content validity and external validity. The Japanese version of the FOS-R appears to be a valid tool for assessing the benefits experienced by families as a result of services received, but further research is needed to determine the nature of practices most likely to lead to positive family outcomes.

    DOI: 10.1016/j.ridd.2015.01.003

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  • 相談支援現場における障がい児家族ニーズのアセスメント指導(FNS-J)の活用 Reviewed

    植田 紀美子

    小児保健研究   73 ( 4 )   591 - 598   2014.7

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  • 2歳未満児の虐待による頭部外傷における初回入院にかかる疾病費用分析 Reviewed

    植田 紀美子, 丸山 朋子, 藤原 武男

    厚生の指標   61 ( 5 )   10 - 14   2014.5

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  • 先天性心疾患の胎児診断における母親への心理的影響 多施設調査結果報告 Reviewed

    河津 由紀子, 植田 紀美子, 西畠 信, 石井 陽一郎, 満下 紀恵, 川滝 元良, 高木 紀美代, 竹田津 未生

    日本小児循環器学会雑誌   30 ( 2 )   175 - 183   2014.3

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  • 病院小児科医師による障害児への障害福祉サービス紹介の実態 Reviewed

    植田 紀美子

    日本公衆衛生雑誌   61 ( 2 )   93 - 99   2014.2

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  • How do pediatricians in Japanese hospitals introduce welfare services to families who have children with disabilities? Reviewed

    Kimiko Ueda

    [Nihon koshu eisei zasshi] Japanese journal of public health   61 ( 2 )   93 - 9   2014

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    DOI: 10.11236/jph.61.2_93

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  • セルフヘルプによるライフステージを通じた相談・支援、啓発活動 すくすく外来拡大啓発事業 Reviewed

    三島 祐子, 植田 紀美子, 松田 圭子, 井上 佳代, 池川 敦子, 川戸 和美, 岡本 伸彦, 江口 奈美, 鷹野 由香, 村田 瑞穂, 酒井 昌子

    大阪府立母子保健総合医療センター雑誌   29 ( 1 )   120 - 122   2013.12

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  • Validity and reliability of the Japanese version of the family needs survey. Reviewed International journal

    Kimiko Ueda, Donald B Bailey Jr, Naohiro Yonemoto, Kuniko Kajikawa, Yuko Nishigami, Sachiko Narisawa, Misako Nishiwaki, Mariko Shibata, Kiyotaka Tomiwa, Akihiro Matsushita, Nodoka Fujie, Kazuo Kodama

    Research in developmental disabilities   34 ( 10 )   3596 - 606   2013.10

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    Early intervention and disability services in Japan historically have focused on supporting the individual with a disability, with only secondary attention to family needs and priorities. Since the Basic Law for Persons with Disabilities was codified in 2011, the Japanese government has been responsible for supporting families with members who have disabilities. To assess the needs of these families, we evaluated the reliability and validity of the Family Needs Survey (FNS), initially developed in 1988 (Bailey & Simeonsson), to determine its usefulness for programs providing services for Japanese families who have a child with a disability. The FNS is a practical tool to assess family needs and is already used across many different cultures and populations. To evaluate the reliability and validity of the FNS, we conducted an anonymous survey with a self-administered questionnaire at 6 treatment and education institutions, 3 medical institutions mainly for children with disabilities, and 39 special needs schools in the Osaka area. We analyzed 1171 parents' survey responses: 452 fathers and 719 mothers of children with disabilities aged 0-15 years old who answered all items on the Japanese version of the FNS. Another survey was administered to 130 specialists who work with children with disabilities to assess the content validity of the Japanese version of the FNS. We verified the factor structure, content validity, and reliability of the Japanese version of the FNS as an assessment tool with 34 items among four factors that were based on the same items in the original FNS. The assessment could be used for families with school-age children as well as younger children, in contrast to the original version, which is not appropriate for school-age children. We also confirmed that it could be used without regard to type or degree of disability.

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  • 子どもの心の診療拠点病院機構推進事業にかかる人的費用推計 Reviewed

    植田 紀美子, 奥山 眞紀子

    厚生の指標   60 ( 7 )   27 - 34   2013.7

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  • Validity and reliability of the Family Needs Survey - Japanese version Reviewed

    Kimiko Ueda, Don Bailey, Naohiro Yonemoto, Kuniko Kajikawa, Yuko Nishigami, Sachiko Narisawa, Misako Nishiwaki, Mariko Shibata, Kiyotaka Tomiwa, Akihiro Matsushita, Nodoka Fujie, Kazuo Kodama

    JOURNAL OF POLICY AND PRACTICE IN INTELLECTUAL DISABILITIES   10 ( 2 )   178 - 179   2013.6

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  • Assessing family outcomes in early intervention: The case of Japan Reviewed

    Kimiko Ueda, Naohiro Yonemoto

    JOURNAL OF POLICY AND PRACTICE IN INTELLECTUAL DISABILITIES   10 ( 2 )   178 - 178   2013.6

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  • 胎児診断における母体への心理的影響の評価 多施設調査結果報告 Reviewed

    河津 由紀子, 植田 紀美子, 石井 陽一郎, 高木 紀美代, 満下 紀恵, 川滝 元良, 竹田津 未生, 西畠 信

    日本周産期・新生児医学会雑誌   48 ( 2 )   365 - 365   2012.6

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  • ダウン症候群総合支援外来の患者および家族に対する効果に関する複合研究 Reviewed

    植田 紀美子, 岡本 伸彦, 松田 圭子, 三島 祐子, 池川 敦子, 井上 佳世, 大町 和美, 鷹野 由香, 江口 奈美, 田中 はるみ, 村田 瑞穂, 田仲 淑子, 手打 和美, 松本 行子, 酒井 昌子, 山下 典子, 高田 佳子, 地頭所 孝子

    大阪府立母子保健総合医療センター雑誌   27 ( 1-2 )   46 - 52   2012.3

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  • ダウン症候群を持つ成人の健康管理に関する調査 肥満とメタボリックシンドロームに着目して Reviewed

    植田 紀美子, 岡本 伸彦, 平山 哲, 巽 純子, 佐川 史郎

    日本遺伝カウンセリング学会誌   32 ( 3 )   101 - 107   2011.9

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  • 小児外来における障害児家族ニーズの現状と課題 Reviewed

    植田 紀美子, 岡本 伸彦, 北島 博之, 中村 安秀

    小児保健研究   70 ( 2 )   270 - 279   2011.3

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  • 「アフリカ新生児・小児保健医療」研修の評価 Reviewed

    杉林 瑞穂, 中村 安秀, 植田 紀美子, 佐藤 拓代

    大阪府立母子保健総合医療センター雑誌   26 ( 2 )   124 - 132   2011.3

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  • 大阪府における子どもの「不慮の事故」による死亡の特徴 Reviewed

    佐伯 しのぶ, 植田 紀美子, 佐藤 拓代

    大阪府立母子保健総合医療センター雑誌   26 ( 2 )   118 - 123   2011.3

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  • セルフヘルプグループに関する総括および情報提供活動 Reviewed

    植田 紀美子, 岡本 伸彦, 酒井 昌子, 田中 はるみ

    大阪府立母子保健総合医療センター雑誌   26 ( 1 )   81 - 82   2010.12

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  • 先天性心疾患の出生前診断を受けた母親への心理的サポートによる胎児診断の有用性の検証 Reviewed

    河津 由紀子, 植田 紀美子

    大阪府立母子保健総合医療センター雑誌   26 ( 1 )   60 - 61   2010.12

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  • 精神健康調査票(短縮版)を用いた小児外来患者家族の精神健康状態の検討 Reviewed

    植田 紀美子, Mbumba Fifi Ngoma, 森 臨太郎, 中村 安秀, 北島 博之, 岡本 伸彦

    日本小児科学会雑誌   114 ( 9 )   1419 - 1426   2010.9

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  • 小児外来患者の療養環境に関する家族ニーズからの検討 Reviewed

    植田 紀美子, 森 臨太郎, 中村 安秀, 岡本 伸彦, 北島 博之, 児玉 和夫

    大阪府立母子保健総合医療センター雑誌   25 ( 1 )   51 - 53   2009.12

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  • 子宮頸がん及び子宮体がん患者の5年生存率に対する地域社会経済因子の影響に関する分析 Reviewed

    植田 紀美子, イチロウカワチ, 津熊 秀明

    成人病   47 ( 3 )   34 - 35   2007.11

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  • Cervical and corpus cancer survival disparities by socioeconomic status in a metropolitan area of Japan. Reviewed International journal

    Kimiko Ueda, Ichiro Kawachi, Hideaki Tsukuma

    Cancer science   97 ( 4 )   283 - 91   2006.4

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    The purpose of this study was to analyze socioeconomic differences in cervical and corpus cancer survival, and to investigate if the differences are due to differences in age, cancer stage, histology and treatment. A total of 14,055 cases with cervical cancer and 3,113 cases with corpus cancer were obtained from the Osaka Cancer Registry. Municipality-based SES measurements were obtained from the System of Social and Demographic Statistics. Survival analysis was carried out with Kaplan-Meier survival curves. Three types of Cox proportional hazards regression models were tested to assess survival differences among groups and effects of SES on survival, controlling for clinical factors. SES was related to age and cancer stage for cervical and corpus cancer patients, and histology for cervical cancer patients. Differences were observed in cumulative 5-year survival for cervical cancer patients among low, middle and high unemployment municipalities (68.9%, 64.3% and 50.9%, respectively, P<0.0001). Differences in cumulative 5-year survival for cervical cancer patients were also observed among high, middle and low education municipalities (65.1%, 62.2% and 56.1%, respectively, P<0.0001). Similar patterns in 5-year survival were also found for corpus cancer patients. After adjusting for age, cancer stage, histology and treatment, survival differences between patients from high and low SES areas still remained. In conclusion, our population-based analysis of a metropolitan representative sample in Japan has demonstrated, for the first time in Japan, SES differences in survival following cervical and corpus cancer.

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  • Socioeconomic factors and cancer incidence, mortality, and survival in a metropolitan area of Japan: a cross-sectional ecological study. Reviewed International journal

    Kimiko Ueda, Hideaki Tsukuma, Wakiko Ajiki, Akira Oshima

    Cancer science   96 ( 10 )   684 - 8   2005.10

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    Cancer mortality is generally high in people of low socioeconomic status compared with people of high socioeconomic status (SES). Although these differences in mortality may be caused by differences in cancer incidence and survival, analysis of these factors has rarely been conducted. The objective of our cross-sectional ecological study was to analyze socioeconomic differences in cancer incidence, mortality and survival in a metropolitan area of Japan. The age-adjusted cancer incidence rates, age-adjusted mortality rates, relative 5-year survival, and proportions of early stage cancer were calculated for 67 municipalities in Osaka, Japan. For area-based socioeconomic variables, we used the percentages of male unemployment, college or graduate school graduates, home ownership, households receiving government assistance, and households below the subsistence habitation level in each municipality. We performed linear regression taking each municipality's population as weight to examine the relationships between measurements relating cancer and socioeconomic variables. Factor analysis of socioeconomic variables was carried out to determine whether a particular socioeconomic variable tended to be associated with another. Cancer incidence, cancer mortality, 5-year cancer survival, and proportion of early stage cancer were highly correlated with each socioeconomic variable at the municipality level. Five area-based socioeconomic variables could be explained by three factors: economic status, housing characteristics and educational attainment. Despite the major limitation of a lack of individual information about socioeconomic characteristics and outcomes related to cancer, we hypothesize that a municipal area's socioeconomic status might be a predictor of individual incidence, mortality, and survival of cancer.

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  • 行政における心的外傷体験への精神的ケアについて Invited Reviewed

    植田 紀美子

    トラウマティック・ストレス   2 ( 2 )   212 - 215   2004.10

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  • Fighting against tobacco companies [3] (multiple letters) Reviewed

    Kimiko Ueda, Masahiro Ohmatsu, Hiroshi Habukawa, Yasunori Sasai

    Lancet   364 ( 9437 )   839 - 840   2004.9

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    DOI: 10.1016/S0140-6736(04)16970-5

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  • 【なぜ?自殺】自殺問題を医療,社会を背景に考える Reviewed

    張 賢徳, 坂本 真士, 小谷津 光子, 植田 紀美子

    こころのりんしょうa・la・carte   23 ( 1 )   5 - 17   2004.3

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  • 地域精神保健活動における「ひきこもり」支援 ガイドライン及び「ひきこもり」の全国調査結果から Reviewed

    植田 紀美子

    公衆衛生   67 ( 10 )   773 - 776   2003.10

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  • 市町村の母子保健計画の策定プロセスと策定後の変化 Reviewed

    藤内 修二, 尾崎 米厚, 福永 一郎, 岩室 紳也, 糸数 公, 犬塚 君雄, 植田 紀美子, 尾島 俊之, 笹井 康典, 澁谷 いづみ, 田上 豊資, 日隅 桂子, 櫃本 真聿, 福島 富士子

    日本公衆衛生雑誌   50 ( 9 )   897 - 907   2003.9

  • [Nationwide survey of municipality's maternal & child health promotion planning processes and consequent changes]. Reviewed

    Shuji Tounai, Yoneatsu Osaki, Ichiro Fukunaga, Shinya Iwamuro, Toru Itokazu, Kimio Inuduka, Kimiko Ueda, Tosiyuki Ojima, Yasunori Sasai, Izumi Shibuya, Toyoshi Tagami, Keiko Higuma, Shinichi Hitsumoto, Fujiko Fukushima

    [Nihon koshu eisei zasshi] Japanese journal of public health   50 ( 9 )   897 - 907   2003.9

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    PURPOSE: The purpose of this study was to offer insight into the revisions needed for promotion of Maternal and Child Health Promotion Plans in the coming years. METHODS: The maternal and child health promotion planning process and changes in maternal and child health services were surveyed by questionnaires to all municipalities in Japan. RESULTS: Completed questionnaires were obtained from 2,362 municipalities (response rate: 72.6%) Replies from 2,202 municipalities, which had completed planning by March, 1998, were analyzed. Planning committees were established by 63.9% of municipalities, and working committees were set up in 55.4% of them. Members involved in the working committees were more limited when compared to the planning committees and only 9.3% of the committees had representatives from mothers. 37.5% of working committees held meetings more than 5 times. 56.0% of municipalities conducted hearings or questionnaire surveys of mothers and health personnel for assessment of maternal and child healthcare needs. Most prefectural public health centers provided statistical data for planning assistance. Public health center staff participated as planning members in 38.5% of municipalities, and a training program for the planning sponsored by health centers was utilized by 33.8% of municipalities. Only 18.3% of municipalities received support for explanation of the plans to the mayor and/or executive officers, only 12.1% received support for the management of the planning committees, and only 11.8% received support for needs analysis. Less than half of minicipalities conducted PR activities of the plans and progress management. A higher proportion conducted these activities in larger cities. After the planning process, 72.9% of municipalities started new projects according to the plans. However, 10.1% scrapped one or more projects. Changes in maternal and child healthcare services and promotion of coordination with other related organization were seen more in municipalities with a larger population. There were major differences found between prefectures with regards to the planning process, including the support from public health centers, and the effective use of plan reports, progress management, and changes in maternal and child healthcare services after the formulation of plans.

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  • National strategy for suicide prevention in Japan. Reviewed International journal

    Kimiko Ueda, Yoshiyuki Matsumoto

    Lancet (London, England)   361 ( 9360 )   882 - 882   2003.3

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  • 自殺予防に果たすかかりつけ医の医割 厚生労働省自殺防止対策有識者懇談会報告「自殺予防に向けての提言」から Reviewed

    植田 紀美子, 泉 陽子, 松本 義幸

    日本医事新報   ( 4116 )   73 - 77   2003.3

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  • 自殺防止対策有識者懇談会報告「自殺予防に向けての提言」について 公衆衛生従事者に期待されること Reviewed

    植田 紀美子

    公衆衛生   67 ( 2 )   124 - 126   2003.2

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  • Estimation of individualized probabilities of developing breast cancer for Japanese women. Reviewed

    Kimiko Ueda, Hideaki Tsukuma, Hideo Tanaka, Wakiko Ajiki, Akira Oshima

    Breast cancer (Tokyo, Japan)   10 ( 1 )   54 - 62   2003

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    BACKGROUND: Projecting individualized probabilities of developing breast cancer is needed for counseling and chemoprevention for Japanese women, in whom breast cancer incidence has been rapidly increasing. METHODS: We calculated individualized probabilities of developing breast cancer within 10-20 years and until life expectancy for Japanese women by multiplying the relative risk for each risk factor combination by the cumulative risk for the reference group. The risk factors used were age at menarche, age at first delivery, family history of breast cancer, and body mass index (BMI) (in post-menopausal women). The relative risk by menopausal status for each risk factor combination was estimated from a case control study conducted at Osaka Medical Center for Cancer and Cardiovascular Diseases (OMCC), Japan. The cumulative risk of breast cancer for the reference group within 10-20 years and until life expectancy was estimated to divide the corresponding cumulative risk for Japanese women by the weighted average of the relative risk. The weight is an expected proportion of those who have each risk factor combination among the general population. The cumulative risk for Japanese women was estimated using a data file from the Osaka Cancer Registry (OCR). RESULTS: We obtained cumulative risks for any age women within a certain range according to various risk factor combinations by menopausal state. For example, the highest risk group had about a 5 times higher risk probability of developing breast cancer than the general population at initial age 40, within 10-20 years, and until life expectancy. CONCLUSION: The cumulative risk of breast cancer varied according to individuals' risk factors among Japanese women. The availability of concrete individualized risk estimation figures will be of use to health care providers in encouraging Japanese women to seek counseling and to adopt self-control of body weight as a primary preventive measure, as well as to have breast cancer screening.

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  • Cigarette nicotine yields and nicotine intake among Japanese male workers Reviewed

    K Ueda, Kawachi, I, M Nakamura, H Nogami, N Shirokawa, S Masui, A Okayama, A Oshima

    TOBACCO CONTROL   11 ( 1 )   55 - 60   2002.3

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  • Nicotine patches in Japan Reviewed

    K Ueda

    LANCET   358 ( 9280 )   512 - 512   2001.8

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  • 禁煙準備過程からみた喫煙行動の特徴 喫煙の生化学的指標を用いた分析 Reviewed

    植田 紀美子, 中村 正和, 城川 法子, 木下 朋子, 増居 志津子, 野上 浩志, 大島 明

    日本公衆衛生雑誌   47 ( 9 )   783 - 791   2000.9

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  • 長期完全静脈栄養中にセレン欠乏症と考えられる皮膚炎を呈した1乳児例 Reviewed

    嶋田 恵子, 植田 紀美子, 梶本 吉孝, 松木 裕子, 吉川 真紀子, 山岡 完次, 馬場 美子, 納谷 保子, 松尾 吉庸

    日本小児科学会雑誌   104 ( 3 )   361 - 364   2000.3

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  • 高張性脱水による意識障害をきたしたロタウイルス感染性腸炎の一例 Reviewed

    嶋田 恵子, 山岡 完次, 植田 紀美子, 松木 裕子, 梶本 吉孝, 馬場 美子, 納谷 保子

    大阪府立病院医学雑誌   22 ( 1 )   60 - 63   1999.12

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  • 急性腎不全及び意識障害を合併したロタウイルス感染性腸炎 Reviewed

    嶋田 恵子, 山岡 完次, 植田 紀美子, 松木 裕子, 古谷 悦美, 梶本 吉孝, 馬場 美子, 納谷 保子, 西田 勝

    日本小児腎不全学会雑誌   19   183 - 186   1999.9

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  • 最近7年間に入院した溶血性尿毒症症候群17症例の検討 Reviewed

    植田 紀美子, 山岡 完次, 松木 裕子, 古谷 悦美, 梶本 吉孝, 馬場 美子, 納谷 保子, 西田 勝

    大阪府立病院医学雑誌   21 ( 1 )   35 - 40   1998.12

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  • メフェナム酸長期服用により自己免疫性溶血性貧血をきたした1例 Reviewed

    植田 紀美子, 石上 佳孝, 西田 勉, 荒井 克己, 元村 正明, 佐藤 智信, 春名 能通, 今野 英一, 宮本 岳, 神田 勤, 片山 良子, 山本 照美, 松渕 登代子

    大阪府立病院医学雑誌   21 ( 1 )   54 - 58   1998.12

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Books

  • ダウン症のある子、赤ちゃんのころから 「ことば」をはぐくむ

    植田紀美子

    かもがわ出版  2023.6  ( ISBN:4780312752

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    Total pages:144  

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  • 成人期ダウン症診療ガイドライン日本語版

    竹内千仙, 井手友美, 植田紀美子, 他.日本ダウン症学会ダウン症成人診療ガイドライン翻訳プロジェクト

    2022 

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  • ダウン症候群のある患者の移行医療支援

    竹内千仙, 玉井浩, 植田紀美子, 他.ダウン症候群の移行医療に関するタスクフォース

    日本ダウン症学会  2021 

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  • 子どもの虐待とネグレクト―診断・治療とそのエビデンス

    一般社団法人 日本子ども虐待医学会, 溝口 史剛, 白石 裕子, 小穴 慎二, 小穴, 慎二(子どものマルトリートメントに関連するコスト)

    金剛出版  2018.2  ( ISBN:477241598X

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    Total pages:1100   Language:Japanese  

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  • こどもと妊婦の病気・治療がわかる本―大阪母子医療センターの今

    大阪母子医療センター(226-228「ダウン症候群」266-267「ボランティア会の活動」288-289「臨床研究部」)

    バリューメディカル  2018.1  ( ISBN:4864890757

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    Total pages:319   Language:Japanese  

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  • 気になる子どもの保育の基本あい・あい保育向上プログラム : 行動観察と小さな目標からはじめる

    あいち小児保健医療総合センター, 今本, 利一, 植田, 紀美子, 山崎, 嘉久

    診断と治療社  2015.3  ( ISBN:9784787821201

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    Total pages:vii, 133p   Language:Japanese  

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  • がん・統計白書2012

    富永, 祐民(「がんの社会格差―生存率」)

    篠原出版新社  2012.4  ( ISBN:4884123573

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    Total pages:280   Language:Japanese  

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  • しっかり学ぶ基礎からの疫学

    柳川 洋, 萱場 一則, 萱場, 一則( Original_author: William Anton Oleckno ,  「疫学研究デザインの概要」)

    南山堂  2004.11  ( ISBN:4525183810

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    Total pages:337   Language:Japanese  

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  • 不平等が健康を損なう

    河内, 一郎, Kennedy, Bruce P., 社会疫学研究会, 西, 信雄, 高尾, 総司, 中山, 健夫(「政治と健康」)

    日本評論社  2004.10  ( ISBN:9784535982376

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    Total pages:ix, 195p   Language:Japanese  

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MISC

  • 新生児黄疸に対する光療法と発達遅滞 子どもの健康と環境に関する全国調査(エコチル調査)より

    堀田 将志, 植田 紀美子, 池原 賢代, 谷川 果菜美, 中山 博文, 和田 和子, 木村 正, 大薗 恵一, 祖父江 友孝, 磯 博康

    日本小児科学会雑誌   128 ( 2 )   264 - 264   2024.2

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  • 新生児黄疸に対する光療法の期間とアレルギー疾患 子どもの健康と環境に関する全国調査(エコチル調査)より

    堀田 将志, 植田 紀美子, 池原 賢代, 谷川 果菜美, 中山 博文, 和田 和子, 木村 正, 大薗 恵一, 祖父江 友孝, 磯 博康

    日本小児科学会雑誌   128 ( 2 )   265 - 265   2024.2

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  • 新生児黄疸に対する光療法と睡眠 子どもの健康と環境に関する全国調査(エコチル調査)より

    堀田 将志, 植田 紀美子, 池原 賢代, 谷川 果菜美, 中山 博文, 和田 和子, 木村 正, 大薗 恵一, 祖父江 友孝, 磯 博康

    日本小児科学会雑誌   128 ( 2 )   220 - 220   2024.2

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  • 発達が気になる子どもに関する子育て世代包括支援 センターへの相談状況と対応

    植田紀美子

    日本公衆衛生学会   ( 抄録集 )   2022.10

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    2022.   81(suppl)   206 - 206   2022

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  • ダウン症者移行期医療の現状と課題ー大阪移行期医療研修会からの考察ー

    植田紀美子, 位田忍, 北畠康司, 中尾正俊, 花房俊昭, 藤原靖弘, 鳥邉泰久, 大園恵一, 岡本伸彦, 植田麻美, 田家由美子, 玉井浩

    日本ダウン症学会   ( 抄録集 )   2021.11

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  • 大阪母子医療センターでのダウン症候群の診療状況

    岡本伸彦, 西恵理子, 長谷川結子, 松田圭子, 川戸和美, 西村夕美子, 植田紀美子

    日本小児遺伝学会   ( 抄録集 )   2021.11

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  • 希少未診断疾患プロジェクトと遺伝カウンセリング

    松田圭子, 川戸和美, 西村夕美子, 植田紀美子, 長谷川結子, 西恵理子, 岡本伸彦

    日本人類遺伝学会   ( 抄録集 )   2021.10

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  • ルビンシュタイン・テイビ症候群における長期的合併症

    川戸和美, 西恵理子, 植田紀美子, 長谷川結子, 岡本伸彦

    日本人類遺伝学会   ( 抄録集 )   2021.10

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  • Gorlin症候群の2症例を通した遺伝カウンセリングの意義

    西村夕美子, 松田恵子, 長谷川結子, 西恵理子, 植田紀美子, 川戸和美, 岡本伸彦

    日本   ( 抄録集 )   2021.10

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  • 驚愕症の家系における遺伝カウンセリング

    西村 夕美子, 松田 圭子, 長谷川 結子, 西 恵理子, 植田 紀美子, 川戸 和美, 三島 祐子, 岡本 伸彦

    日本遺伝カウンセリング学会誌   42 ( 2 )   110 - 110   2021.6

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  • 大阪母子医療センターにおけるIRUD未診断疾患イニシアチブ研究状況

    岡本伸彦, 西恵理子, 植田紀美子, 長谷川結子, 西村夕美子, 川戸和美, 三島祐子, 松田圭子

    関西出生前診療研究会・臨床細胞分子遺伝研究会   ( 抄録集 )   2021.3

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  • ダウン症のある児の移行医療

    植田紀美子

    第2回日本ダウン症学会学術集会会議集   2020.11

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  • 15 番染色体の父性片親性ダイソミーによるHERC2 及び AP3B2 変異を合併したアンジェルマン症候群の一例

    植田 紀美子, 小川 哲, 松田 圭子, 長谷川 結子, 西 恵理子, 柳 久美子, 要 匡, 山本 俊至, 岡本 伸彦

    日本人類遺伝学会   ( 抄録集 )   2020.11

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  • DCX遺伝子に変異が認められた2家系の遺伝カウンセリング

    西村夕美子, 松田圭子, 長谷川結子, 西恵理子, 植田紀美子, 川戸和美, 三島祐子, 柳久美子, 要匡, 岡本伸彦

    日本人類遺伝学会   ( 抄録集 )   2020.11

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  • エクソーム解析等からMyhre症候群と診断された小児5例

    三島祐子, 松田圭子, 川戸和美, 西村夕美子, 西恵理子, 長谷川結子, 植田紀美子, 岡本伸彦

    日本人類遺伝学会   ( 抄録集 )   2020.11

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  • 大阪府南部児童虐待防止医療ネットワーク事業 ~実績と課題~

    馬迫れいか, 植田紀美子, 佐々木歩, 川口めぐみ, 福井伊左子, 田家由美子, 平山哲, 三宅和佳子, 小杉恵, 光田信明

    日本子ども虐待防止学会   ( 抄録集 )   2020.11

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  • 「にんしんSOS」相談から見えてきたこと第6報~10年目を迎えこれまでの事業総括~

    植田紀美子, 馬迫れいか, 佐々木歩, 中西眞弓, 光田信明

    日本子ども虐待防止学会   ( 抄録集 )   2020.11

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  • 母子保健と社会的ハイリスク妊婦 続報~包括支援センター整備後の「にんしんSOS」

    植田紀美子

    日本公衆衛生学会総会抄録集   79   359 - 359   2020.10

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  • 妊婦の自閉症傾向特性の特徴について 子どもの健康と環境に関する全国調査

    廣川 空美, 木村 尚史, 池原 賢代, 本庄 かおり, 植田 紀美子, 佐藤 拓代, 磯 博康

    日本公衆衛生学会総会抄録集   79回   360 - 360   2020.10

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  • ダウン症候群の乳児と家族を対象とした集団外来10年のまとめ

    植田紀美子, 岡本伸彦

    小児保健研究   79 ( 講演集 )   200 - 200   2020.9

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  • 遺伝子解析を行った家族性海綿状血管腫家系

    三島 祐子, 松田 圭子, 川戸 和美, 西 恵理子, 長谷川 結子, 植田 紀美子, 岡本 伸彦

    日本遺伝カウンセリング学会誌   41 ( 2 )   114 - 114   2020.6

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  • 13トリソミー症候群の発達・リハビリテーション介入の有効性の評価

    西 恵理子, 植田 紀美子, 岡本 伸彦, 古庄 知己

    日本小児遺伝学会学術集会   ( 抄録集 )   2020.2

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  • 子どもの発達を伸ばす療育は?-児童発達支援センターコホート研究より

    植田紀美子

    日本ダウン症会議集   2019.11

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  • 総合周産期医療センターにおける出生後早期からのダウン症候群総合支援外来

    三島祐子, 植田紀美子, 松田圭子, 川戸和美, 西恵理子, 長谷川結子, 池川敦子, 川本祥子, 岡本伸彦

    第1回日本ダウン症会議集   2019.11

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  • Menke-Hennekam syndromeの4 例

    植田 紀美子, 宮 冬樹, 柳 久美子, 要 匡, 水野 誠司, 小崎 健次郎, 西 恵理子, 岡本 伸

    日本人類遺伝学会学術集会   2019.11

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  • 日本公衆衛生学会モニタリング委員会【障害・難病グループ】平成30・令和元年度報告

    鈴木 仁一, 植田 紀美子, 杉井 たつ子, 橘 とも子, 谷掛 千里, 橋本 佳美

    日本公衆衛生学会総会抄録集   78回   460 - 460   2019.10

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  • 家族アウトカム及び子どもの発達に影響を及ぼす児童発達支援内容の検討

    植田 紀美子

    日本公衆衛生学会総会抄録集   78回   457 - 457   2019.10

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  • ダウン症候群の小児から成人期のことまで見据えた生涯ケアを目指して ライフステージに応じたトータルケア 豊かな成人期をめざして

    植田 紀美子

    大阪小児科学会誌   36 ( 3 )   8 - 8   2019.9

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  • 大阪母子医療センターにおける先天性難聴患者の遺伝学的診断と遺伝カウンセリング

    西 恵理子, 川戸 和美, 松田 圭子, 三島 祐子, 植田 紀美子, 岡本 伸彦

    日本遺伝カウンセリング学会誌   40 ( 2 )   136 - 136   2019.7

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  • 大阪府南部児童虐待防止医療ネットワーク事業の実績と課題

    仁木 敦子, 植田 紀美子, 山田 麻記子, 小杉 恵, 三宅 和佳子, 平山 哲, 田家 由美子, 福井 伊左子, 川口 めぐみ, 中川 紋子, 山崎 和美, 祖父江 由佳, 浅田 留美子, 佐藤 拓代, 光田 信明

    小児保健研究   78 ( 講演集 )   204 - 204   2019.5

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  • 飯舘村での母子保健活動の取組み 養育者を主体とした育児支援ツールの導入について

    佐野 碧, 児山 洋平, 黒田 佑次郎, 植田 紀美子, 後藤 あや

    福島県保健衛生雑誌   33   45 - 48   2019.3

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  • 全村避難後の飯舘村の保健活動における育児支援ツールの開発の過程

    佐野 碧, 児山 洋平, 黒田 佑次郎, 赤石澤 愛, 八代 千賀子, 松田 久美子, 植田 紀美子, 後藤 あや

    日本衛生学雑誌   74 ( Suppl. )   S139 - S139   2019.2

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  • 小児医療の国際化を目指して 海外医療従事者研修を通じた国際貢献

    植田 紀美子, 和田 和子, 倉智 博久

    日本小児科学会雑誌   123 ( 2 )   160 - 160   2019.2

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  • DHX30遺伝子変異による神経発達障害の1例

    植田紀美子, 上原朋子, 小崎健次郎, 岡本伸彦

    日本小児遺伝学会学術集   2019.1

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  • ダウン症候群総合支援外来「すくすく外来」第5報

    三島祐子, 植田紀美子, 松田圭子, 川戸和美, 西恵理子, 長谷川結子, 池川敦子, 川本祥子, 岡本伸彦

    日本人類遺伝学会大会プログラム・抄録集   64th   2019

  • エコチル調査大阪ユニットセンターにおける質問票回収に影響する地理的要因の検討

    谷川果菜美, 木村尚史, 池原賢代, 池原賢代, 董加毅, 崔美善, 青地ゆり, 植田紀美子, 磯博康

    日本疫学会学術総会講演集(Web)   29th   2019

  • エコチル調査大阪ユニットセンターにおける質問票回収に影響する要因の検討

    崔 美善, 木村 尚史, 董 加毅, 池原 賢代, 植田 紀美子, 磯 博康

    日本公衆衛生学会総会抄録集   77回   380 - 380   2018.10

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  • 児童発達支援ガイドラインの取組状況 発達支援(療育)に関する全国調査結果

    植田 紀美子

    日本公衆衛生学会総会抄録集   77回   458 - 458   2018.10

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  • 日本公衆衛生学会モニタリング委員会【障害・難病グループ】平成29・30年度活動報告

    鈴木 仁一, 植田 紀美子, 橘 とも子, 谷掛 千里, 橋本 佳美

    日本公衆衛生学会総会抄録集   77回   457 - 457   2018.10

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  • 総合周産期母子医療センターの社会的ハイリスク妊婦 地域関係機関との連携から

    仁木 敦子, 植田 紀美子, 佐藤 拓代

    日本公衆衛生学会総会抄録集   77回   400 - 400   2018.10

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  • 【日本におけるWHO協力センター】大阪母子医療センターのWHO指定研究協力センター(母子保健分野)活動 総合周産期母子医療センターとしての強みを生かして

    植田 紀美子

    公衆衛生   82 ( 9 )   680 - 685   2018.9

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  • 大阪母子医療センターにおける先天性難聴の遺伝学的診断と遺伝カウンセリング

    西 恵理子, 植田 紀美子, 岡本 伸彦

    日本小児科学会雑誌   122 ( 2 )   462 - 462   2018.2

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  • パリビズマブ投与によるダウン症候群乳幼児のRSウイルス感染予防効果 多施設共同研究

    植田 紀美子, 北畠 康司, 和田 和子, 二川 弘司, 吉橋 博史, 西久保 敏也, 外木 秀文, 西 恵理子, 岡本 伸彦

    日本小児科学会雑誌   122 ( 2 )   461 - 461   2018.2

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  • エビデンスに基づいた障害保健福祉施策の推進 モニタリングから見えてきたこと 地域保健福祉活動のエビデンス蓄積の重要性

    植田 紀美子

    日本公衆衛生学会総会抄録集   76回   166 - 166   2017.10

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  • 児童発達支援事業提供体制の格差の現状

    植田 紀美子

    日本公衆衛生学会総会抄録集   76回   550 - 550   2017.10

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  • 頭蓋縫合早期癒合症を合併した歌舞伎症候群の6例

    植田 紀美子, 川戸 和美, 三島 祐子, 松田 圭子, 山本 悠斗, 西 恵理子, 岡本 伸彦

    日本遺伝カウンセリング学会誌   38 ( 2 )   113 - 113   2017.5

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  • 大阪母子医療センターのIRUD-P症例の解析状況とVUSの評価について

    川本 祥子, 松田 圭子, 川戸 和美, 三島 祐子, 山本 悠斗, 渋川 幸直, 田尻 道子, 大門 江津子, 山崎 奈津子, 植田 紀美子, 岡本 伸彦

    日本遺伝カウンセリング学会誌   38 ( 2 )   113 - 113   2017.5

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  • ダウン症候群の幼児と家族を対象とした就学までのフォローアップ集団外来の報告

    植田 紀美子, 岡本 伸彦

    小児保健研究   76 ( 講演集 )   165 - 165   2017.5

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  • 日本公衆衛生学会モニタリング委員会【障害グループ】の平成27年度活動報告

    鈴木 仁一, 植田 紀美子, 橘 とも子, 谷掛 千里, 橋本 佳美

    日本公衆衛生学会総会抄録集   75回   541 - 541   2016.10

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  • ダウン症候群の乳児と家族を対象とした総合支援外来の家族への効果に関する研究

    植田 紀美子, 岡本 伸彦

    小児保健研究   75 ( 講演集 )   195 - 195   2016.5

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  • 次世代シーケンサーを用いた先天異常症候群解析と遺伝カウンセリング

    山本 悠斗, 松田 圭子, 川戸 和美, 三島 祐子, 植田 紀美子, 岡本 伸彦

    日本遺伝カウンセリング学会誌   37 ( 1 )   72 - 72   2016.3

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  • 日本公衆衛生学会モニタリング委員会【障害グループ】の平成26年度活動報告

    鈴木 仁一, 植田 紀美子, 谷掛 千里, 橋本 佳美

    日本公衆衛生学会総会抄録集   74回   422 - 422   2015.10

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  • 療育効果指標"家族アウトカム質問票(FOS-J)"の一般化に関する研究

    植田 紀美子

    日本公衆衛生学会総会抄録集   74回   428 - 428   2015.10

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  • 歌舞伎症候群40例の臨床遺伝学的検討

    植田 紀美子, 松田 圭子, 三島 祐子, 吉井 啓志, 三宅 紀子, 松本 直通, 岡本 伸彦

    日本遺伝カウンセリング学会誌   36 ( 2 )   87 - 87   2015.5

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  • 当院における患者家族交流会と遺伝カウンセラーの役割

    三島 祐子, 植田 紀美子, 松田 圭子, 川戸 和美, 吉井 啓志, 岡本 伸彦

    日本遺伝カウンセリング学会誌   36 ( 2 )   88 - 88   2015.5

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  • ジンバブエ周産期医療向上に向けた国際交流事業

    光田 信明, 岡本 陽子, 宮川 祐三子, 北島 博之, 白石 淳, 植田 紀美子, Patronellah Davidzoyashe

    大阪府立母子保健総合医療センター雑誌   30 ( 2 )   130 - 130   2014.12

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  • 児童発達支援センターにおける療育支援サービス効果についての評価 全国実態調査結果

    植田 紀美子

    日本公衆衛生学会総会抄録集   73回   501 - 501   2014.10

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  • 「あい・あい保育向上プログラム」の障がい児保育における効果研究

    植田 紀美子, 後藤 あや, 山崎 嘉久

    小児保健研究   73 ( 講演集 )   156 - 156   2014.5

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  • ダウン症候群総合支援外来「すくすく外来」(第4報)

    三島 祐子, 植田 紀美子, 松田 圭子, 川戸 和美, 池川 敦子, 村田 瑞穂, 江口 奈美, 鷹野 由香, 岡本 伸彦

    日本遺伝カウンセリング学会誌   35 ( 2 )   67 - 67   2014.5

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  • 小児外科医ができる国際協力 途上国医師の本邦医療機関での臨床研修の経験

    石井 智浩, 米田 光宏, 曹 英樹, 田附 裕子, 山中 宏晃, 野村 元成, 松浦 玲, 出口 幸一, 福澤 正洋, 木内 恵子, 谷口 晃啓, 佐藤 拓代, 植田 紀美子, 窪田 昭男

    日本小児外科学会雑誌   50 ( 3 )   611 - 611   2014.4

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  • JICA国際協力によるバングラデシュ小児外科医研修

    米田 光宏, 曹 英樹, 田附 裕子, 山中 宏晃, 野村 元成, 松浦 玲, 出口 幸一, 佐藤 拓代, 植田 紀美子, 福澤 正洋, 窪田 昭男

    日本小児外科学会雑誌   50 ( 3 )   610 - 610   2014.4

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  • 障がい児の育ちにおける保育所の役割 質的研究による検討

    植田 紀美子, 今本 利一, 小島 千恵子, 後藤 あや, 山崎 嘉久, 佐藤 拓代

    小児保健研究   72 ( 講演集 )   124 - 124   2013.8

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  • Clarification of answers to an open-ended question: "Please list your five greatest needs as a family" with needs listed on the Family Needs Survey - Japanese version

    Kimiko Ueda, Naohiro Yonemoto, Kuniko Kajikawa, Yuko Nishigami, Sachiko Narisawa, Misako Nishiwaki, Mariko Shibata, Kiyotaka Tomiwa, Akihiro Matsushita, Nodoka Fujie, Kazuo Kodama

    JOURNAL OF POLICY AND PRACTICE IN INTELLECTUAL DISABILITIES   10 ( 2 )   179 - 179   2013.6

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  • 障害児家族ニーズのアセスメント指標(FNS-J)の活用指針

    植田 紀美子, 佐藤 拓代

    日本公衆衛生学会総会抄録集   71回   428 - 428   2012.10

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  • 子ども虐待の背景要因としての障害児

    佐藤 拓代, 石塚 りか, 植田 紀美子

    小児保健研究   71 ( 講演集 )   157 - 157   2012.7

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  • 療育効果評価のための日本版家族アウトカム質問票(Family Outcome Survey-Japanese version:FOS-J)の信頼性・妥当性の検証

    植田 紀美子, 佐藤 拓代

    小児保健研究   71 ( 講演集 )   168 - 168   2012.7

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  • ダウン症候群の児を出産した直後の母の心理的状況について すくすく外来報告(第2報)

    植田 紀美子, 岡本 伸彦, 松田 圭子, 三島 祐子, 池川 敦子, 井上 佳世, 大町 和美, 鷹野 由香, 江口 奈美, 村田 瑞穂

    日本遺伝カウンセリング学会誌   33 ( 2 )   99 - 99   2012.5

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  • 先天性心疾患の出生前診断を受けた母親への心理的サポート(母体支援)の啓発および調査

    河津 由紀子, 植田 紀美子

    大阪府立母子保健総合医療センター雑誌   27 ( 1-2 )   62 - 62   2012.3

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  • 障害児家族のニーズアセスメント指標の開発(第1報) ニーズの実態把握

    植田 紀美子, 成澤 佐知子, 西脇 美佐子, 梶川 邦子, 西上 優子, 柴田 真理子, 松下 彰宏, 富和 清隆, 藤江 のどか, 米本 直裕, 佐藤 拓代

    日本公衆衛生学会総会抄録集   70回   262 - 262   2011.10

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  • ダウン症候群を持つ成人の健康管理に関する調査

    植田 紀美子, 岡本 伸彦, 平山 哲, 巽 純子, 松田 圭子, 秋丸 憲子, 三島 祐子, 池川 敦子, 佐川 史郎

    日本遺伝カウンセリング学会誌   32 ( 2 )   105 - 105   2011.5

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  • ダウン症候群を持つ成人の健康管理に関する調査

    植田 紀美子, 岡本 伸彦, 平山 哲, 巽 純子, 松田 圭子, 秋丸 憲子, 三島 祐子, 池川 敦子, 佐川 史郎

    家族性腫瘍   11 ( 2 )   A105 - A105   2011.5

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  • 特発性腎性低尿酸血症を認めたダウン症候群の一例

    植田 紀美子, 岡本 伸彦

    日本小児科学会雑誌   115 ( 2 )   427 - 427   2011.2

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  • 未管理妊娠・飛び込み分娩の養育問題と育児支援 府立母子医療センターの事例分析より

    山下 典子, 酒井 昌子, 藤江 のどか, 石上 悦子, 浅野 浩子, 植田 紀美子

    日本未熟児新生児学会雑誌   22 ( 3 )   544 - 544   2010.10

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  • 大阪府における子どもの「不慮の事故」による死亡の特徴

    佐伯 しのぶ, 植田 紀美子, 佐藤 拓代

    日本公衆衛生学会総会抄録集   69回   325 - 325   2010.10

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  • 障がい児の療育環境に関する家族ニーズからの検討

    植田 紀美子, Ngoma Mbumba Fifi, 森 臨太郎, 中村 安秀, 北島 博之, 児玉 和夫, 岡本 伸彦

    日本公衆衛生学会総会抄録集   68回   517 - 517   2009.10

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  • 地域社会経済指標を用いたがん患者の生存率等格差の検討

    植田 紀美子, 井岡 亜希子, 大島 明

    日本公衆衛生学会総会抄録集   65回   297 - 297   2006.10

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  • 全館禁煙宣誓医療機関証の発行等による医療機関におけるたばこ対策の推進(第3報)

    西田 明子, 植田 紀美子, 森脇 俊, 大松 正宏, 土生川 洋, 中村 正和, 笹井 康典, 大島 明

    日本公衆衛生学会総会抄録集   64回   309 - 309   2005.8

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  • 立入検査を活用したたばこ対策に関する病院調査と保健医療行政における意義(第2報)

    植田 紀美子, 大松 正宏, 土生川 洋, 中村 正和, 笹井 康典, 大島 明

    日本公衆衛生学会総会抄録集   63回   389 - 389   2004.10

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  • うつ病対策 地域におけるうつ対策検討会報告から

    植田 紀美子

    公衆衛生   68 ( 4 )   298 - 300   2004.4

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  • 厚生労働省における自殺予防対策について

    植田 紀美子

    臨床死生学   8 ( 1 )   85 - 85   2003.11

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  • 禁煙の準備性からみた喫煙行動の生化学的指標分析

    植田 紀美子, 中村 正和, 木下 朋子, 城川 法子, 増居 志津子

    日本健康教育学会誌   7 ( Suppl. )   260 - 261   1999.5

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  • 特異な帯状角膜変性症様病変を呈した1症例

    植田 紀美子

    眼科臨床医報   91 ( 7 )   1119 - 1120   1997.7

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Research Projects

  • 保育現場における障がい児とその家族のニーズを中心とする災害管理の指針の作成

    Grant number:24K05850  2024.4 - 2029.3

    日本学術振興会  科学研究費助成事業  基盤研究(C)

    山脇 功次, 後藤 あや, 植田 紀美子, 宗像 佑華

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    Grant amount:\4550000 ( Direct Cost: \3500000 、 Indirect Cost:\1050000 )

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  • Health inequality among children and an application of universal approach to parenting supports.

    Grant number:22K02394  2022.4 - 2025.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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  • Visualizing the mechanism of transferring health literacy skills to the next generation

    Grant number:19K03120  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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  • Cohort study for verification to introduce Universal Approach into the child-raising families general support center

    Grant number:19K02638  2019.4 - 2022.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

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    Grant amount:\4290000 ( Direct Cost: \3300000 、 Indirect Cost:\990000 )

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  • 母親及び小児の尿中バイオマーカーと高血圧・糖尿病への進展に関するコホート研究

    Grant number:18H03058  2018.4 - 2023.3

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    池原 賢代, 磯 博康, 植田 紀美子

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    Grant amount:\17160000 ( Direct Cost: \13200000 、 Indirect Cost:\3960000 )

    本年度は、本研究の実施に向けた倫理審査の手続きを進め、承認を得た。本年度の具体的な研究の実施内容としては、母親の妊娠初期及び中後期の凍結保存尿を利用し、尿中微量アルブミンの測定を行った。測定結果をもとに解析用データベースを作成し、尿中微量アルブミン濃度と妊娠中の血圧値及びその変化との関連について分析を進めた。また、次年度からの小児健康診査の実施に向け、質問票作成、会場設定、案内用資料等の準備や関係機関との調整を進め、会場及び実施日程を確定した。

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  • Risk communication after the nuclear accident: developing a health literacy toolkit for health care workers

    Grant number:16K09135  2016.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Goto Aya, Yumiya Yui

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    Grant amount:\4810000 ( Direct Cost: \3700000 、 Indirect Cost:\1110000 )

    Health care workers in Fukushima confronted difficulties in risk communication. We developed a pocket-size "health literacy toolkit" that contained a glossary explaining radiation-related terms in plain language and an index to measure the accessibility of both text and numerical information. Public health nurses, who attended health literacy training workshops using the toolkit, showed more positive attitudes toward community residents' feedback on their activities. Furthermore, written health materials revised by the trainees were evaluated as easier to understand compared to the original versions developed before the training.

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  • Effects of early intervention programs on children's development and family outcomes in Japan : a prospective cohort study

    Grant number:15K01792  2015.4 - 2019.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    Ueda Kimiko, Yamane Kiyoko

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    Grant amount:\4680000 ( Direct Cost: \3600000 、 Indirect Cost:\1080000 )

    Benefits to families as well as children are critical goals of early intervention. When parents are provided guidance for establishing a positive family environment and receive supportive care, developmental outcomes for children with disabilities are optimal. To provide systematically well-tailored supports to children with disabilities and their families is very important in early intervention. We clarified what kind of interventions to children have positive effects on behaviors and development of children and their family outcomes.

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  • Development and utilization of the Japanese version of the Family Outcomes Survey- Revised, and a national survey of evaluating methods of early intervention programs in Japan

    Grant number:24600033  2012.4 - 2015.3

    Japan Society for the Promotion of Science  Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)  Grant-in-Aid for Scientific Research (C)

    UEDA Kimiko, NAOHIRO Yonemoto

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    Grant amount:\5460000 ( Direct Cost: \4200000 、 Indirect Cost:\1260000 )

    Although it is common knowledge that family-centered care is effective for both children and families, service providers in Japan have not adopted this approach because there is no existing concept of family outcomes. Evaluating outcomes for families of children with disabilities can be a way of monitoring early intervention programs. For the first time in Japan, we developed and validated the Japanese version of the Family Outcomes Survey- Revised (the FOS-J). We also clarified that more than 60% of early interventioninstitutions did not assess effects of their program on children with disabilities and more than 80% did not assess them on their families.The FOS-J could be a possible tool to evaluate and compare early intervention programs among institutions that provide these programs in Japan.

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  • 被災後の対応を含めた在宅障害児支援ツールの開発に関する研究

    2012.4 - 2015.3

    厚生労働省  厚生労働科学研空費補助金(地域医療基盤研究事業) 

    五十嵐隆, 植田紀美子

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  • 介入効果測定のための虐待現状把握およびその社会的コスト試算に関する研究

    2011.4 - 2014.3

    厚生労働省  厚生労働科学研究費補助金(政策科学推進研究事業) 

    藤原武, 植田紀美子

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  • 子どもの心の診療およびその拠点病院システムの費用と効果に関する研究

    2011.4 - 2012.3

    厚生労働省  厚生労働科学研究費補助金(成育疾病克服等次世代育成基盤研究事業) 

    奥山真紀子, 植田紀美子

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  • 障害児をもつ家族に対するニーズアセスメント指標の開発と小児病院と地域が連携した包括的な支援方策に関する研究

    2010.4 - 2012.3

    厚生労働科学研究費補助金  障害者対策総合研究事業(身体・知的等障害分野) 

    植田 紀美子

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    Authorship:Principal investigator 

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Teaching Experience

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