2024/05/17 更新

写真a

イトウ タケシ
伊藤 健
ITO,Takeshi
所属
システム理工学部 教授
職名
教授
外部リンク

学位

  • 工学博士 ( 2007年2月 )

研究分野

  • ナノテク・材料 / ナノ材料科学

  • ナノテク・材料 / ナノバイオサイエンス

  • ナノテク・材料 / 薄膜、表面界面物性

所属学協会

委員歴

  • 学術振興会 R041バイオ・分子・ナノテクノロジー融合委員会   学界委員  

    2022年4月 - 2027年3月   

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論文

  • High productivity of immunostimulatory membrane vesicles of <i>Limosilactobacillus antri</i> using glycine 査読

    Shino YAMASAKI-YASHIKI, Yu SAKAMOTO, Keiko NISHIMURA, Azusa SAIKA, Takeshi ITO, Jun KUNISAWA, Yoshio KATAKURA

    Bioscience of Microbiota, Food and Health   43 ( 1 )   55 - 63   2024年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:BMFH Press  

    DOI: 10.12938/bmfh.2023-029

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  • 微粒子投射によって形成された微細凹凸の抗菌性能 査読

    西谷伴子, 斉藤邦夫, 萩原秀実, 伊藤健

    表面技術   74 ( 8 )   412 - 416   2023年8月

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    担当区分:最終著者   掲載種別:研究論文(学術雑誌)  

    DOI: 10.4139/sfj.74.412

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  • Electroless Plating of Ru Using Hydrazine Hydrate as a Reducing Agent 査読

    Ryota Saida, Tomohiro Shimizu, Takeshi Ito, Yukihiro Tominari, Shukichi Tanaka, Naoki Fukumuro, Shinji Yae, Shoso Shingubara

    Journal of Electronic Materials   52 ( 10 )   6690 - 6698   2023年7月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    DOI: 10.1007/s11664-023-10605-5

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    その他リンク: https://link.springer.com/article/10.1007/s11664-023-10605-5/fulltext.html

  • Cicada wing-inspired artificial nanopatterns with antifouling properties for clay adhesion 査読

    Zihao Zhao, Tomohiro Shimizu, Shoso Shingubara, Takeshi Ito

    Physica Scripta   98 ( 8 )   085929 - 085929   2023年7月

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    担当区分:責任著者   掲載種別:研究論文(学術雑誌)   出版者・発行元:IOP Publishing  

    Abstract

    To clarify the antifouling properties of cicada-inspired nanostructured surfaces and search for a long-term usable antifouling material, the wings of two types of cicadas in Japan, Graptopsaltria nigrofuscata (GN) and Cryptotympana facialis (CF), were examined by surface wettability and surface free energy. Furthermore, considering the complexity and mechanical stability of natural nanostructured surfaces, we mimicked both cicada wing surfaces by combining nanosphere lithography and metal-assisted chemical etching (MacEtch) on Si wafer, which is low-cost and large-area pattern-fabricable. We obtained artificial nanopatterns with pillar pitches of 200, 500, and 1000 nm (naming 200, 500, and 1000 series). As a result, comparing artificial nanopatterns with cicada wings indicated that nanopillar structures with high roughness factors or structural aspect ratios are likely to have excellent hydrophobic properties and antifouling features. Cryptotympana facialis wings and 200 series Si samples showed less clay particle adhesion than other patterns. These results indicate smaller structured surfaces where air may get trapped, resulting in hydrophobic surfaces contributing to self-cleaning or fouling-release properties. Further, reducing the contact area between nanostructures and clay can be used as an effective strategy to prevent clay adhesion has been proposed, but it has targeted limitations. Herein, we present a novel insight that more fine and high-structural-density nanostructural patterns are universal to prevent clay adhesion.

    DOI: 10.1088/1402-4896/ace562

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    その他リンク: https://iopscience.iop.org/article/10.1088/1402-4896/ace562/pdf

  • Fabrication and characterization of field-effect transistors based on MoS2 nanotubes prepared in anodic aluminum oxide templates 査読

    Naoya Shiraiwa, Kyosuke Murata, Takuto Nakazawa, Akihiro Fukawa, Koichi Takase, Takeshi Ito, Shoso Shingubara, Tomohiro Shimizu

    Micro and Nano Engineering   19   100200 - 100200   2023年6月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.mne.2023.100200

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  • Fluorescence Intensity of Liposomes and <i>E. coli</i> Attached to Nanopillar Arrays: Implications for Bacterial Death on Nanostructures

    Masato Daimon, Yushi Yanagisawa, Kenta Ishibashi, Yukihiro Tominari, Shukichi Tanaka, Hiroaki Kojima, Tomohiro Shimizu, Shoso Shingubara, Takeshi Ito

    ACS Applied Nano Materials   6 ( 3 )   1610 - 1619   2023年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:American Chemical Society (ACS)  

    DOI: 10.1021/acsanm.2c04489

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  • Polymeric Antibacterial Surfaces with Nano-pillar Arrays Mimicking Cicada Wings 査読

    Natsuki Ogawa, Kodai Sato, Kayano Sunada, Hisashi Ishiguro, Hiroaki Kojima, Takeshi Ito

    Journal of Photopolymer Science and Technology   35 ( 3 )   213 - 217   2022年12月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Technical Association of Photopolymers, Japan  

    DOI: 10.2494/photopolymer.35.213

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  • Fabrication and UV photoresponse of ordered ZnO nanonets using monolayer colloidal crystal template

    Yusuke Kiyomi, Naoya Shiraiwa, Takuto Nakazawa, Akihiro Fukawa, Kaito Oshio, Koichi Takase, Takeshi Ito, Shoso Shingubara, Tomohiro Shimizu

    Micro and Nano Engineering   16   100160 - 100160   2022年8月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Elsevier BV  

    DOI: 10.1016/j.mne.2022.100160

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  • Antibacterial effect on microscale rough surface formed by fine particle bombarding

    Tomoko Nishitani, Kyosuke Masuda, Soma Mimura, Takahiko Hirokawa, Hitoshi Ishiguro, Masao Kumagai, Takeshi Ito

    AMB Express   12 ( 1 )   2022年1月

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Springer Science and Business Media LLC  

    Abstract

    Fine particle bombarding (FPB) is typically utilized to modify metal surfaces by bombarding them with fine particles at high-speed. The diameters of the particles range from several to tens of micrometers. FPB forms fine microscale concavities and convexities on a surface. As FPB-treated surfaces are widely used in the food industry, the influence of bacteria on their surface must be considered. In this study, we examined the antibacterial activity of microscale rough surfaces formed by FPB. We applied FPB to a stainless-steel surface and evaluated the antibacterial effect of FPB-treated surfaces based on JIS Z 2801 (a modified test method from ISO 22196:2007). Our results indicated that the FPB-treated surfaces (FPB-1 (avg. pitch: 0.72 µm) and FPB-2 (avg. pitch: 3.56 µm)) exhibited antibacterial activity both against Escherichia coli and Staphylococcus aureus.

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    DOI: 10.1186/s13568-022-01351-8

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    その他リンク: https://link.springer.com/article/10.1186/s13568-022-01351-8/fulltext.html

  • Bactericidal effect of nanostructures <i>via</i> lytic transglycosylases of <i>Escherichia coli</i>

    Soma Mimura, Tomohiro Shimizu, Shoso Shingubara, Hiroaki Iwaki, Takeshi Ito

    RSC Advances   12 ( 3 )   1645 - 1652   2022年

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    掲載種別:研究論文(学術雑誌)   出版者・発行元:Royal Society of Chemistry (RSC)  

    The time profiles of active cell ratios depended on the growth phase and the absence of some lytic transglycosylases of E. coli. Significant cell damage was not found on the autolysis inhibition condition.

    DOI: 10.1039/d1ra07623j

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  • Detailed analysis of liposome adsorption and its rupture on the liquid-solid interface monitored by LSPR and QCM-D integrated sensor 査読

    Asai, Naoto, Matsumoto, Naohiro, Yamashita, Ichiro, Shimizu, Tomohiro, Shingubara, Shoso, ITO, Takeshi

    Sensing and Bio-Sensing Research   32   2021年4月

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  • Effect of asymmetric thin TiN buffer layer for switching in NbOx layer 査読

    R. Hatanaka, M. Morimoto, S. Nakamura, T. Shimizu, T. ITO, S. Shingubara

    Japanese Journal of Applied Physics   60   2021年

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  • Adhesion and Bactericidal Properties of Nanostructured Surfaces Dependent on Bacterial Motility

    Keisuke Jindai, Kazuki Nakade, Takashi Sagawa, Hiroaki Kojima, Tomohiro Shimizu, Shoso Shingubara, Takeshi Ito

    RSC Advances   10, 5673   2020年

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  • Electrochemical impedance spectroscopy study of liposome adsorption and rupture on self-assembled monolayer: Effect of surface charge

    Yusuke Fujino, Ryo Nakamura, H. W. Han, Ichiro Yamashita, Tomohiro Shimizu, Shoso Shingubara, Takeshi Ito

    Journal of Electroanalytical Chemistry   878, 114572   2020年

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  • Nano-honeycomb electrode based QCM sensor and its application for PPI detection 査読

    Naoto Asai, Naohiro Matsumoto, Nozomi Kazama, Yasuo Nagaoka, Takaaki Sumiyoshi, Tomohiro Shimizu, Shoso Shingubara, Takeshi Ito

    IEEE Sensors Journal   2019年2月

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    An anodic aluminon oxide (AAO)-based nano honeycomb electrode was coated on a quartz crystal for use as a sensing device in a quartz crystal microbalance (QCM) to monitor the protein-protein interactions (PPIs). As examples, we detected PPIs of anti-Bcl-2 and Bcl-2, and Bcl-2 and Bax in real time. A sensor with a flat Au electrode showed a tiny frequency shift upon sample injection. However, our fabricated device could detect 10 μg/mL of Bcl-2 and Bax in sequence.

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  • Fabrication of highly sensitive QCM sensor using AAO nanoholes and its application in biosensing

    Naoto Asai, Tomohiro Shimizu, Shoso Shingubara, Takeshi Ito

    Sensors and Actuators   276, 536   2018年

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  • Adhesion and bactericidal properties of a wettability-controlled artificial nanostructure

    Kazuki Nakade, Keisuke Jindai, Takashi Sagawa, Hiroaki Kojima, Tomohiro Shimizu, Shoso Shingubara, Takeshi Ito

    ACS Applied Nano materials   1, 5736   2018年

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  • Highly Sensitive QCM based biosensor using Au dendrite structure 査読

    Naoto Asai, Hideaki Terasawa, Tomohiro Shimizu, Shoso Shingubara, Takeshi Ito

    Japanese Journal of Applied Physics   57   2018年

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  • Detection of stress hormone in the milk for animal welfare using QCM method 査読

    T. Ito, N. Aoki, A. Tsuchiya, S. Kaneko, K. Akiyama, K. Uetake, K. Suzuki

    Journal of Sensors   2017, 6486891   2017年9月

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  • ZnO Nanostructure based QCM sensor to detect Ethanol at room temperature fabricated by all wet process

    T. Ito, N. Yamanishi, T. Shimizu, S. Shingubara

    Proceedings   2017 (1) 397   2017年8月

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  • Sensitized mass change detection using Au nanoporous electrode for biosensing 査読

    Naoto Asai, Hideaki Terasawa, Tomohiro Shimizu, Shoso Shingubara, Takeshi Ito

    JAPANESE JOURNAL OF APPLIED PHYSICS   56 ( 6 )   2017年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IOP PUBLISHING LTD  

    Nanostructured Au was obtained on an electrode of a quartz crystal microbalance (QCM) chip by anodization in an oxalic acid solution. The effective surface area was expanded by these nanostructures and evaluated by electrochemical measurement, scanning electron microscopy (SEM), and atomic force microscopy (AFM). Several morphologies, such as a nanosphere and a spongy structure, were observed under various anodic conditions. We demonstrated that a QCM chip with an anodized Au electrode was effective in biosensing because of its large surface area. The frequency shift corresponding to an antigen-antibody reaction improved on a Au nanosphere electrode compared with a flat surface electrode and spongy structure. (C) 2017 The Japan Society of Applied Physics

    DOI: 10.7567/JJAP.56.06GG04

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  • Layer-by-Layer Growth of Graphene on Insulator in CO2-Oxidizing Environment 査読

    Satoru Kaneko, Takeshi Ito, Chihiro Kato, Satomi Tanaka, Shigeo Yasuhara, Akifumi Matsuda, Mamoru Yoshimoto

    ACS Omega   2 ( 4 )   1523 - 1528   2017年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:American Chemical Society  

    Since the discovery of graphene by sticking and peeling scotch tape off graphite, it has also been prepared by other methods, such as thermal decomposition of SiC and chemical vapor deposition (CVD) with catalytic layer. Both the exfoliation and CVD methods impose to transfer the graphene layers on other insulating substrates for device applications. We reported that diamond grows in oxygen atmosphere (Yoshimoto, M.
    et al. Nature 1999, 399, 340-342) in which oxidative etching and depositing carbon compete under equivalent conditions. However, oxygen atmosphere is too intense for graphite growth. Although carbon dioxide (CO2) is produced after hydrocarbon combustion, it can be a gentle and tender oxidant in certain situations. Here, we show the direct growth of graphene on insulating substrates in 100% CO2 environment and observe its layer-by-layer growth on the stepped edge of an insulating substrate. The direct growth can have a significant advantage of excluding the necessary process of transferring the graphene on the insulating substrate over other common methods.

    DOI: 10.1021/acsomega.7b00140

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  • Nonenzymatic detection of glucose using BaCuO2 thin layer

    Takeshi Ito, Tsuyoshi Asada, Naoto Asai, Tomohiro Shimizu, Shoso Shingubara

    JAPANESE JOURNAL OF APPLIED PHYSICS   56 ( 1 )   2017年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IOP PUBLISHING LTD  

    A BaCuO2 thin layer was deposited on a glassy carbon electrode and used for the direct oxidation of glucose. The crystalline, electrochemical, and physicochemical properties that depend on the deposition temperature and deposition time were studied. X-ray diffraction (XRD) analysis showed that the thin layer was amorphous even at 400 degrees C. The current density of the glucose oxidation using the thin layer deposited at 200 degrees C was higher than those at other deposition temperatures. Under this condition, the current density increased with the glucose concentration and deposition time. These results indicate that a BaCuO2 thin layer has potential for measuring the blood glucose level without enzymes. (C) 2017 The Japan Society of Applied Physics

    DOI: 10.7567/JJAP.56.01AH02

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  • Antibacterial property of Si nanopillar array fabricated using metal assisted etching; mimic a cicada wing 査読

    T. Ito, K. Nakade, N. Asai, T. Shimizu, S. Shingubara

    ECS Transactions   75(53), 1-5   2017年

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  • 制御可能なナノ構造を利用した高感度センサと抗菌素材の創出

    伊藤 健

    ケミカルエンジニアリング   1-6   2016年7月

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    ナノ構造の作製法やそれを用いたデバイスについて紹介。

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  • Fabrication of nanocone arrays by two step metal assisted chemical etching method

    Tomohiro Shimizu, Norihiro Tanaka, Yoshihiro Tada, Yasuhiro Hara, Noriaki Nakamura, Junichi Taniuchi, Koichi Takase, Takeshi Ito, Shoso Shingubara

    MICROELECTRONIC ENGINEERING   153   55 - 59   2016年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    This work develops a novel method for preparing a moth eye structure, which has a sub-wavelength periodical Si nanocone structure on Si(100) substrate, using two-step metal assisted chemical etching (MACE). The 1st MACE and 2nd MACE were respectively performed with the intention to form perpendicular Si nanowire arrays on a Si substrate and sharpening the Si nanowire arrays. We found that the inhomogeneous absorption and aggregation of Au particles used as a catalyst for the 2nd MACE was important to obtain the nanocone shape. The obtained Si nanocone arrays showed superior anti-reflecting properties especially in a wavelength below 600 nm compared with the Si nanowire arrays. A possible mechanism involved in the formation of the nanocone structure by the 2 step MACE is discussed in this paper. (C) 2016 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.mee.2016.01.030

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  • Antibacterial characteristics of Si nano-pillar array 査読

    Takeshi Ito, Kazuki Nakade, Naoto Asai, Tomohiro Shimizu, Shoso Shingubara

    2016 IEEE 16TH INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (IEEE-NANO)   82 - 84   2016年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:IEEE  

    Cicada wings have nanostructures which shows superhydrophobic property, non reflecting to the light, and antibacterial characteristics. To mimic the nano structure of a cicada wing, we fabricated nano-pillar array using metal assisted etching. Fabricated nano-pillar array showed higher antibacterial property for E. coli. Our introduced process has advantages for industrial usage because of low cost and low environmental load based on wet process.

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  • Magnetic conductive filament formed in the ReRAM device with ferromagnetic electrode

    Hayaco Yoshida, Tomohiro Shimizu, Takeshi Ito, Shoso Shingubara

    ECS Transactions   75 ( 32 )   65 - 71   2016年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:Electrochemical Society Inc.  

    We studied magnetic conduction property of the conductive filament formed in the ReRAM device having two ferromagnetic electrodes. Anisotropic Magnetoresistance (AMR) property was observed in the ON-state of the devices, however, negative MR occurred for the one device and positive MR occurred for another devices, There were abrupt change of resistance around 250 mT for these devices. Micromagnetic simulation study strongly suggested that the abrupt change of MR was caused by the single domain switching of the magnetic conductive filament (MCF). Furthermore, it is suggested that typical MCF size was 40 x 40 x 4 nm1 by assuming that MCF was composed of Ni metals, It is also suggested that the difference of negative AMR and positive AMR is derived from the location of MCF. The present results suggest a possibility of new multilevel memory devices which can be operated by both electric field as well as magnetic field.

    DOI: 10.1149/07532.0065ecst

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  • Fabricating a QCM device with the nanostructures using the AAO template

    N. Asai, T. Ito, T. Shimizu, S. Shingubara

    CHEMICAL SENSORS 12: CHEMICAL AND BIOLOGICAL SENSORS AND ANALYTICAL SYSTEMS   75 ( 16 )   229 - 232   2016年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:ELECTROCHEMICAL SOC INC  

    The nano structure derived from Anodic Aluminum Oxide (AAO) is controllable by the anodizing conditions such as voltage, anodizing time, and the acid solutions. Regularly arranged nanopores were fabricated with high aspect ratio. We tried to use the nano structure as a template to build nanowire array on the quartz crystal to enlarge the surface area bond to analyte. Evaluating the shape of the nanowire, average of the height and the diameter of the nanowire were 1 mu m and 50 nm, respectively. In this case, high aspect ratio more than 20 was achieved. We fabricated nanowires on the electrode of the QCM chip and tried to detect the antigenantibody reaction.

    DOI: 10.1149/07516.0229ecst

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  • Electrodeposited ZnO thin film on twin sensor QCM for sensing of ethanol at room temperature

    Takeshi Ito, Yudai Fujii, Noriyoshi Yamanishi, Naoto Asai, Tomohiro Shimizu, Shoso Shingubara

    PROCEEDINGS OF THE 30TH ANNIVERSARY EUROSENSORS CONFERENCE - EUROSENSORS 2016   168   411 - 414   2016年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:ELSEVIER SCIENCE BV  

    QCM is one of major sensing methods for volatile organic compounds (VOC), however, the method is affected by environments such as temperature, humidity, and airflow. To cancel the signals affected by environments, we used twin sensor QCM which has two electrodes on one quartz substrate. In fact, one Au electrode was used as a reference, and ZnO thin film was electrodeposited on the other electrode to detect ethanol. The surface morphology of ZnO was changed corresponding to the applied potential on the electrodeposition. Scaly surface was obtained at -0.8 V vs. Ag/AgCl. QCM with scaly ZnO surface showed high frequency change on exposing to ethanol gas. (C) 2016 The Authors. Published by Elsevier Ltd.

    DOI: 10.1016/j.proeng.2016.11.192

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  • Sequential analysis of β-lactogloblin for allergen check using QCM with a passive flow system 査読

    Takeshi Ito, Nobuyoshi Aoki, Akihisa Tsuchiya, Satoru Kaneko, Koji Suzuki

    Chemistry Letters   44, (7), 981-983   2015年6月

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  • Expansion of lattice constants of aluminum nitride thin film prepared on sapphire substrate by ECR plasma sputtering method 査読

    Satoru Kaneko, Hironori Torii, Takao Amazawa, Takeshi Ito, Manabu Yasui, Masahito Kurouchi, Akinori Fukushima, Takashi Tokumasu, Seughwan Lee, Sungkyun Park, Hirofumi Takikawa, Mamoru Yoshimoto

    JAPANESE JOURNAL OF APPLIED PHYSICS   53 ( 11 )   2014年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IOP PUBLISHING LTD  

    Wurzite aluminum nitride is prepared on a c-plane sapphire substrate by electron cyclotron resonance plasma-enhanced sputtering deposition (ECR sputtering). Atomic force microscopy (AFM) showed flat AlN thin-film surfaces, and X-ray diffraction (XRD) analysis verified the epitaxial growth of AlN films with the full-width at half-maximum (FWHM) of the rocking curve of 0.025 deg on the film with the thickness of 100 nm. XRD analysis also verified the change in the peak position for the AlN film along both out-of-plane and in-plane directions. The effect of lattice constants on the energy gap was theoretically estimated by the first principles method. (C) 2014 The Japan Society of Applied Physics

    DOI: 10.7567/JJAP.53.11RA11

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  • Duplicate analysis of cortisol for stress check using QCM with self – suction flow system

    Takeshi Ito, Nobuyoshi Aoki, Wakako Shinobu, Koji Suzuki

    Procedia Engineering   87   296 - 299   2014年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

    DOI: 10.1016/j.proeng.2014.11.666

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  • Highly sensitive and rapid sequential cortisol detection using twin sensor QCM

    Takeshi Ito, Nobuyoshi Aoki, Satoru Kaneko, Koji Suzuki

    ANALYTICAL METHODS   6 ( 18 )   7469 - 7474   2014年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ROYAL SOC CHEMISTRY  

    We present a rapid cortisol detecting system with the integration of flow injection analysis in order to adapt sequential analysis. The detecting system consists of a twin sensor chip on quartz crystal micro balance (QCM) method. One sensor monitored antigen-antibody interaction, together with the other sensor as a reference to remove environmental influences. A competitive assay was performed on monitoring the antigen-antibody interaction using cortisol coupled with bovine serum albumin (Crt-BSA) as a tracer. The binding between antigen and antibody could be uncoupled with a glycine-NaOH solution to adapt sequential analysis. One detection cycle, including regeneration step was performed within 10 minutes at a flow rate of 6 mu L min(-1). The sensor system could quantitatively detect cortisol levels ranging from 5 pg mL(-1) to 100 pg mL(-1). These results indicated the sensor system has the potential to be used for active stress-monitoring and in the diagnosis of disease.

    DOI: 10.1039/c4ay01387e

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  • Preparation of Diamond-Like Carbon on Ti Film with Tetramethylsilane Buffer Layer 査読

    Satoru Kaneko, Takahiro Horiuchi, Takeshi Ito, Shin-ichi Takagi, Manabu Yasui, Mitsuhiro Saitoh, Takashi Matsunaga, Kaoru Ikenaga, Shigeo Yasuhara, Katsuhiro Mihirogi, Masazumi Kobayashi, Masao Kumagai, Eiji Shimodaira, Rieko Sudo

    JAPANESE JOURNAL OF APPLIED PHYSICS   52 ( 11 )   2013年11月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IOP PUBLISHING LTD  

    Diamond-like carbon (DLC) has been applied as a coating material to improve the basic properties of strength, chemical stability, and biocompatibility. In this study, a DLC film was prepared on a titanium (Ti) coating film with tetramethylsilane (TMS) buffer for application in vivo. Although the surface roughness of the Ti film increased with increasing Ti thickness, both TMS and DLC coatings deposited on Ti films resulted in the formation of a flat surface. Observation of the initial growth of the TMS layer indicated that a TMS buffer of more than 50nm thickness was required for DLC coating even on the flat surface of the Ti thin film. (C) 2013 The Japan Society of Applied Physics

    DOI: 10.7567/JJAP.52.11NA02

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  • Functional surface on periodical nanostructure self-organized by laser scanning at speed of 300 m/min 査読

    Satoru Kaneko, Takeshi Ito, Chihiro Kato, Satomi Tanaka, Yosuke Ono, Tokuo Yodo, Hiroyasu Nakata, Akira Matsuno, Takashi Nire, Akifumi Matsuda, Mamoru Yoshimoto

    Optics and Lasers in Engineering   51 ( 3 )   294 - 298   2013年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    After CW lasers scanned a target at high speed of 300 m/min, periodical nanostructure self-organized on the target surface. Unlike fiber-like structure fabricated by femtosecond laser, the periodic structure showed trench structures with flat bottoms. A theoretical simulation of thermal distribution of the target indicated the target temperature exceeds its melting point, which was verified by micro-Raman spectroscopy. The time dependent thermal distribution indicated the existence of threshold melting period to form the trench nanostructure. The nanostructure showed well-regulated gratings, and the precise periodicity emerged structural color and modified water-repellent on the target surface. © 2012 Elsevier Ltd.

    DOI: 10.1016/j.optlaseng.2012.09.011

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  • Growth of Nanocubic MgO on Silicon Substrate by Pulsed Laser Deposition 査読

    Satoru Kaneko, Takeshi Ito, Masayasu Soga, Yu Motoizumi, Manabu Yasui, Yasuo Hirabayashi, Takeshi Ozawa, Mamoru Yoshimoto

    JAPANESE JOURNAL OF APPLIED PHYSICS   52 ( 1 )   2013年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IOP PUBLISHING LTD  

    Magnesium oxide (MgO) prepared by both pulsed laser deposition and sputtering methods showed constriction of lattice constants. To emphasize the effect of the constriction of lattice constants, MgO prepared at high oxygen atmosphere and high substrate temperature, resulted in the growth of cubic-shaped magnesium oxide (MgO) nanoparticles on a Si substrate. In oxygen atmosphere, the nanocubic MgO was scattered on the substrate without the Si surface being covered by a MgO thin film. Interestingly, the growth of nanocubic MgO was restrained on the samples prepared in nitrogen atmosphere. The formation of nanocubic MgO is related to the deposition pressure as well as the etching effect provided by oxygen atmosphere. (C) 2013 The Japan Society of Applied Physics

    DOI: 10.7567/JJAP.52.01AN02

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  • Properties of epitaxial AlN thin film deposited on sapphire substrate by ECR plasma 査読

    Satoru Kaneko, Takeshi Ito, Manabu Yasui, Masahito Kurouchi, Takatoshi Nagano, Hironori Torii, Takao Amazawa, Lee Seughwan, Sungkyun Park, Takashi Tikumasu, Hirofumi Takikawa

    2013 IEEE 6TH INTERNATIONAL CONFERENCE ON ADVANCED INFOCOMM TECHNOLOGY (ICAIT)   69 - +   2013年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:IEEE  

    We prepared AlN film on c-plane sapphire substrate by electron cyclotron resonance plasma-enhanced sputtering deposition (ECR-sputtering). X-ray diffraction (XRD) verified the epitaxial growth of AlN films with the full width at half maximum (FWHM) of rocking curve of 0.04 deg. even on the film thickness of 100 nm. XRD also verified slight change of peak position from AlN film along both out of plane and in-plane directions.

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  • High performance of Hydrogen Peroxide Detection Using Pt Nanoparticles–Dispersed Carbon Electrode Prepared by Pulsed Arc Plasma Deposition

    Takeshi Ito, Masayuki Kunimatsu, Satoru Kaneko, Yasuo Hirabayashi, Masayasu Soga, Yoshiaki Agawa, Koji Suzuki

    Talanta   99   865 - 870   2012年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.talanta.2012.07.048

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  • Fabrication of 3D Interdigitated Array Electrode Consisting of Au Nanoparticles and Its Application for Biosensing 査読

    Takeshi Ito, Nobuyoshi Aoki, Satoru Kaneko, Koji Suzuki

    ELECTROCHEMISTRY   80 ( 5 )   305 - 307   2012年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELECTROCHEMICAL SOC JAPAN  

    We developed a 3D interdigitatecl (IDA) array electrode consisting of Au nano particles, which increase the electrode surface. The electrode was fabricated using microfabrication and printing techniques. Electrochemical impedance spectroscopy was conducted to measure IgG concentration, when anti-IgG was immobilized onto Dithiobis (succinimidyl propionate) (DTSP) SAM/3D-IDA electrode. A linear relationship between charge transfer resistance (R-ct) values and the logarithm of IgG concentration was observed in the range of 1 mu g/ml to 1 mg/ml. (C) The Electrochemical Society of Japan, All rights reserved.

    DOI: 10.5796/electrochemistry.80.305

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  • Effect of point defects on lattice constant in MgO thin film deposited on silicon(001) substrate 査読

    S. Kaneko, T. Nagano, T. Ito, M. Yasui, T. Ozawa, M. Soga, Y. Motoizumi, H. Funakubo, M. Yoshimoto

    EUROPEAN PHYSICAL JOURNAL-APPLIED PHYSICS   58 ( 1 )   2012年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:EDP SCIENCES S A  

    Epitaxial magnesium oxide (MgO) thin films prepared on Si(0 0 1) substrates revealed the contraction of its lattice constants along both out-of-plane and in-plane directions. X-ray Diffraction (XRD) verified the epitaxial growth with the relation of MgO(1 0 0) parallel to Si(1 0 0) [cubic on cubic growth] with large lattice misfit of similar to 22% instead of the relation of MgO(1 1 0) parallel to Si(1 0 0) [45 degrees rotation growth] with lattice mismatch of similar to 9%. Although the domain epitaxy explaining the cubic on cubic growth is preferred in terms of crystallography, structural stability is not considered in the concept of the domain epitaxy. In order to explain the contraction of lattice constant from point of view of structural stability, ab initio method was used to evaluate all-electron total energy, and optimal lattice constant was estimated with point defects in the MgO structure.

    DOI: 10.1051/epjap/2012110247

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  • Nano-Cube MgO Formed on Silicon Substrate Using Pulsed Laser Deposition 査読

    Satoru Kaneko, Takeshi Ito, Kensuke Akiyama, Manabu Yasui, Yasuo Hirabayashi, Masayasu Soga, Yumiko Miyake, Mamoru Yoshimoto

    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY   12 ( 3 )   2320 - 2325   2012年3月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER SCIENTIFIC PUBLISHERS  

    Nano-cube MgO particles were formed on Si substrates by deposition of an MgO target using pulsed laser deposition method. An epitaxial film grows on Si(001) substrate with its contraction of lattice constants.(19) In this study, expecting high quality MgO film, the MgO film prepared in the oxygen pressure ranging from 75 similar to 400 mTorr at the high temperature of similar to 750 degrees C. The deposited MgO showed the growth of (001) preferred orientation on the Si(001) substrate. However, X-ray Photoelectron Spectroscopy (XPS) indicated the MgO film did not form a continuous film on the Si surface. Interestingly, the surface morphology observed by an Atomic Force Microscopy (AFM) showed nano-cube MgO particles scattered on the smooth surface of Si substrate. After annealing the nano-cube MgO, the shape of MgO particles were changed from nano-cube to round shaped particles. The AFM image of the surface showed round shaped MgO nanoparticles scattered on rough surface. X-ray Diffraction (XRD) revealed the epitaxial growth of MgO(001) with cubic on cubic arrangement on the Si(001) substrate (MgO[100] parallel to Si[100]).

    DOI: 10.1166/jnn.2012.5688

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  • Thermal stability of back side metallization multilayer for power device application

    Takeshi Ito, Isamu Taguchi, Masayasu Soga, Masahiko Mitsuhashi, Toshiro Shinohara, Toshinori Ogashiwa, Takashi Nishimori, Nobuyuki Akiyama

    MICROELECTRONICS RELIABILITY   52 ( 1 )   199 - 205   2012年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:PERGAMON-ELSEVIER SCIENCE LTD  

    Metallization multilayers on the back side of a power device were focused in this study. Si wafers coated with high melting point metals were exposed at 300 degrees C for 300 h to investigate diffusion condition of the metallization layer. We developed and examined the thermal stability oldie bonding material (Au paste) including sub-micrometer-sized Au particles. Auger electron spectroscopy was applied to observe the atomic composition of the multilayers in depth direction after the high temperature aging. Surface morphology was observed using optical microscope and scanning electron microscope. While atomic composition on Ti/Au changed drastically after the high temperature aging, other multilayers maintained their metallization composition. However, the surface morphology was slightly changed on Ti/Ru/Au, W/Au, and Ta/Au. Bond strength on the Ti/Pt/Au kept over 40 MPa with unified bonding layer after exposing at 300 degrees C for 1000 h. (C) 2011 Elsevier Ltd. All rights reserved.

    DOI: 10.1016/j.microrel.2011.07.094

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  • Periodic nano trench structure fabricated by high speed scanning CW laser 査読

    Satoru Kaneko, Takeshi Ito, Manabu Yasui, Chihiro Kato, Satomi Tanaka, Takeshi Ozawa, Yasuo Hirabayashi, Akira Matsuno, Takashi Nire, Mamoru Yoshimoto

    LASER APPLICATIONS IN MICROELECTRONIC AND OPTOELECTRONIC MANUFACTURING (LAMOM) XVII   8243   2012年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:SPIE-INT SOC OPTICAL ENGINEERING  

    We report periodic nanostructure on solid material irradiated by scanning continuous wave (CW) laser. Long periodic nano strip grating lines (nano-SGL) formed, not in a spot, but along the trace of the beam scan, literally parallel to each other with a flat trough between the strip lines. The period of nanostructure was varied with the laser power between 500 nm and 800 nm, which equals to wavelengths used for laser scanning of green and infrared lasers. Thermal simulation and Raman spectra indicated the temperature of target exceeded the melting temperature to form the periodic nanostructure on target materials.

    DOI: 10.1117/12.905970

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  • Fabrication of Column Chip Made of PMMA for µFIA

    Takeshi Ito, Satoru Kaneko, Koji Suzuki

    Talanta   85 ( 1 )   707 - 712   2011年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.talanta.2011.04.053

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  • Optimizing coverage of metal oxide nanoparticle prepared by pulsed laser deposition on nonenzymatic glucose detection 査読

    Satoru Kaneko, Takeshi Ito, Yasuo Hirabayashi, Takeshi Ozawa, Tetsuya Okuda, Yu Motoizumi, Kiyohito Hirai, Yasuhiro Naganuma, Masayasu Soga, Mamoru Yoshimoto, Koji Suzuki

    TALANTA   84 ( 2 )   579 - 582   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    Metal oxide nanoparticles prepared by pulsed laser deposition (PLO) were applied to nonenzymatic glucose detection. NiO nanoparticles with size of 3 nm were deposited on glassy carbon (GC) and silicon substrates at room temperature in an oxygen atmosphere. Transmission electron microscope (TEM) image showed nanoparticles with the size of 3 nm uniformly scattered on the Si(0 0 1) substrate. Unlike co-sputtering nanoparticle and carbon simultaneously, the PLO method can easily control the surface coverage of nanoparticles on the surface of substrate by deposition time. Cyclic voltammetry was performed on the samples deposited on the GC substrates for electrochemical detection of glucose. The differences between peak currents with and without glucose was used to optimize the coverage of nanoparticles on carbon electrode. The results indicated that optimal coverage of nanoparticles on carbon electrode. (C) 2011 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.talanta.2010.12.040

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  • Nano-strip grating lines self-organized by a high speed scanning CW laser

    Satoru Kaneko, Takeshi Ito, Kensuke Akiyama, Manabu Yasui, Chihiro Kato, Satomi Tanaka, Yasuo Hirabayashi, Akira Mastuno, Takashi Nire, Hiroshi Funakubo, Mamoru Yoshimoto

    NANOTECHNOLOGY   22 ( 17 )   2011年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:IOP PUBLISHING LTD  

    After a laser annealing experiment on Si wafer, we found an asymmetric sheet resistance on the surface of the wafer. Periodic nano-strip grating lines (nano-SGLs) were self-organized along the trace of one-time scanning of the continuous wave (CW) laser. Depending on laser power, the nano-trench formed with a period ranging from 500 to 800 nm with a flat trough between trench structures. This simple method of combining the scanning laser with high scanning speed of 300 m min(-1) promises a large area of nanostructure fabrication with a high output. As a demonstration of the versatile method, concentric circles were drawn on silicon substrate rotated by a personal computer (PC) cooling fan. Even with such a simple system, the nano-SGL showed iridescence from the concentric circles.

    DOI: 10.1088/0957-4484/22/17/175307

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  • Effect of CW laser annealing on silicon surface for application of power device 査読

    Satoru Kaneko, Takeshi Ito, Kensuke Akiyama, Manabu Yasui, Chihiro Kato, Satomi Tanaka, Yasuo Hirabayashi, Takeshi Ozawa, Akira Matsuno, Takashi Nire, Hiroshi Funakubo, Mamoru Yoshimoto

    World Academy of Science, Engineering and Technology   74   335 - 337   2011年2月

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    As application of re-activation of backside on power device Insulated Gate Bipolar Transistor (IGBT), laser annealing was employed to irradiate amorphous silicon substrate, and resistivities were measured using four point probe measurement. For annealing the amorphous silicon two lasers were used at wavelength of visible green (532 nm) together with Infrared (793 nm). While the green laser efficiently increased temperature at top surface the Infrared laser reached more deep inside and was effective for melting the top surface. A finite element method was employed to evaluate time dependent thermal distribution in silicon substrate.

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  • Electrochemical Response of Platinum Ultrathin Layer Formed by Pulsed Laser Deposition

    Takeshi Ito, Satoru Kaneko, Masayuki Kunimatsu, Yasuo Hirabayashi, Masayasu Soga, Koji Suzuki

    INTERNATIONAL JOURNAL OF ELECTROCHEMISTRY   2011   2011年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:HINDAWI LTD  

    Ultrathin layer of platinum (ULPt) was deposited on glassy carbon (GC) substrate by using pulsed laser deposition (PLD) method, and electrochemical properties of the ULPt were discussed. The deposition was simply performed at room temperature with short deposition time. Atomic force microscopy and scanning electron microscopy images showed the flat surface of the ULPt. X-ray photoelectron spectroscopy (XPS) characterized the ULPt in the Pt(0) state, and biding energy of ULPt was positively shifted. These results indicated that nanostructure of Pt thin layer was formed. The electrochemical activity of the prepared ULPt on GC substrate was superior to a bulk Pt electrode regarding the potential and the magnitude of current on oxidizing hydrogen peroxide. This fast and easily prepared low-cost electrode had the potential to replace a conventional bulk metal electrode.

    DOI: 10.4061/2011/463281

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  • Effect of post annealing on MgO thin film prepared on silicon(001) substrate in high oxygen pressure and high substrate temperature by pulsed laser deposition 査読

    Satoru Kaneko, Kensuke Akiyama, Takeshi Ito, Manabu Yasui, Takeshi Ozawa, Masayasu Soga, Yu Motoizumi, Mamoru Yoshimoto

    IOP Conference Series: Materials Science and Engineering   18 ( 1 )   2011年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)  

    Epitaxial growth of MgO was verified with the relation of MgO(100) parallel to Si(100) (cubic on cubic growth) even with a large mismatch of lattice constants ∼ 22%, instead of 9% mismatch in 45° rotation growth. MgO films prepared at higher deposition temperature showed (001) preferred orientation on Si(001) substrate. After post-annealing the MgO thin films, the pole figure of X-ray diffraction verified the epitaxial growth of cubic on cubic relation. Fe3Si thin film was deposited on Si(001) substrate with the MgO film as buffer layer. © 2011 Ceramic Society of Japan.

    DOI: 10.1088/1757-899X/18/2/022018

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  • Large Lattice Misfit on Epitaxial Thin Film: Coincidence Site Lattice Expanded on Polar Coordinate System 査読

    Satoru Kaneko, Kensuke Akiyama, Takeshi Ito, Manabu Yasui, Masayasu Soga, Yasuo Hirabayashi, Hiroshi Funakubo, Mamoru Yoshimoto

    JAPANESE JOURNAL OF APPLIED PHYSICS   49 ( 8 )   2010年8月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC APPLIED PHYSICS  

    The growth of an epitaxial film with a large lattice misfit to substrates is interpreted as domain growth with domain matching by the coincidence site 1 lattice (CSL), in which it is assumed that (m x n) film lattice units are superimposed on (k x l) substrate lattice units The domain matching with all combinations of two lattice units was expanded on a polar coordinate system (polar CSL figure), where the radius and angle are indicative of the domain size and the lateral angle between two superimposed lattices, respectively The polar CSL figure enable us to visualize the domain matching of all combinations between the two lattice units (k x l) and (m x n) The cubic-on-cubic growth of magnesium oxide on a silicon substrate and the lateral rotation of bismuth cuprate oxide were taken as examples of visualization using the polar CSL figure (C) 2010 The Japan Society of Applied Physics

    DOI: 10.1143/JJAP.49.08JE02

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  • Large constriction of lattice constant in epitaxial magnesium oxide thin film: Effect of point defects on lattice constant 査読

    Satoru Kaneko, Takatoshi Nagano, Kensuke Akiyama, Takeshi Ito, Manabu Yasui, Yasuo Hirabayashi, Hiroshi Funakubo, Mamoru Yoshimoto

    JOURNAL OF APPLIED PHYSICS   107 ( 7 )   2010年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER INST PHYSICS  

    Epitaxial thin films prepared using an MgO target on silicon substrate often show constriction of lattice constant (a similar to 4.1 angstrom). Detailed investigation of the crystal structure excluded the possibility that the epitaxial films are either cubic spinel MgO or magnesium silicate (a/2 similar to 4.1 angstrom). With such a constriction in rock salt MgO structure point defects must be induced into structure. An ab initio method with semicore pseudopotentials predicted such constrictions on configurations of Schottky type defects. The Schottky defects with random distribution throughout lattice cites satisfied constricted lattice constant, mass density, and crystallography experimentally observed on the epitaxial MgO films. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3361482]

    DOI: 10.1063/1.3361482

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  • Electrochemical response and surface morphology of metal nanoparticles by pulsed laser deposition

    T. Ito, S. Kaneko, Y. Hirabayashi, M. Soga, K. Suzuki

    ECS Transactions   25 ( 24 )   19 - 25   2010年

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    掲載種別:研究論文(国際会議プロシーディングス)  

    We studied electrochemical responses and morphologies of metal nanoparticles (MNPs) which were prepared by using pulsed laser deposition (PLD) method. Pt and NiO were deposited on a silicon (Si) and a grassy carbon (GC) substrate. Atomic force microscopy (AFM) and scanning electron microscopy (SEM) images did not determine their nanoparticles. Auger Electron Spectroscopy (AES) and X ray Photoelectron Spectroscopy (XPS) for Pt and NiO coated Si substrates showed that MNPs were certainly formed. Pt with the deposition time of 60 sec had highest activity to detect hydrogen peroxide in phosphate buffer solution. NiO with the deposition time of 90 sec showed highest activity to detect glucose in sodium hydroxide solution. These characteristics might be caused by catalytic activity of MNPs. ©The Electrochemical Society.

    DOI: 10.1149/1.3316108

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  • Preliminary study of a microbeads based histamine detection for food analysis using thermostable recombinant histamine oxidase from Arthrobacter crystallopoietes KAIT-B-007

    Takeshi Ito, Tetsuya Hiroi, Tsutomu Amaya, Satoru Kaneko, Mayumi Araki, Toshiyuki Ohsawa, Akira Yamamura, Kunio Matsumoto

    TALANTA   77 ( 3 )   1185 - 1190   2009年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    We designed and prepared a micro biosensing system consisting of a flow through system with a sub-micro liter injection valve and a sub-micro liter volume bioreactor. An electrochemical detector was combined with the reactor for immediate detections.The volumes of the reactor and the sample loop for the injection were 850 nl and 320 nl, respectively. This paper described about the characteristics of the sensing system in the case of histamine detection for food analysis. Histamine oxidase from KAIT-B-007 was prepared by using a gene recombination technique and they were immobilized with chitosan beads (phi = 70-105 mu m). The detection less than one minute after injection made possible fast analysis for histamine.The biosensing system also showed a high performance for histamine detection in wide range of 1 mu M- 1 mM. In addition, we practically measured histamine content in raw tuna stored at room temperature and 35 degrees C up to 96 h. As a result of the comparison between our sensing system and HPLC method, there was good agreement. These results show that our microfluidic biosensing system has the potential to assist miniaturization with small sample volume and short determination time for a sequential food analysis. (C) 2008 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.talanta.2008.08.018

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  • Fabrication and Characterization of a Thin µ-PEMFC with Microfabricated Grooves on Electroformed Current Collector Plate

    Takeshi Ito, Satoru Kaneko, Masayuki Kunimatsu

    Electrochemical and Solid–State Letters   12 ( 11 )   B154 - B157   2009年

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    記述言語:英語   掲載種別:研究論文(学術雑誌)  

    DOI: 10.1149/1.3202382

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  • Supercell structure on continuous growth of Bi2Sr2Ca1Cu2Ox film 査読

    Satoru Kaneko, Kensuke Akiyama, Takeshi Ito, Yasuo Hirabayashi, Hiroshi Funakubo, Mamoru Yoshimoto

    JAPANESE JOURNAL OF APPLIED PHYSICS   47 ( 7 )   5602 - 5604   2008年7月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC APPLIED PHYSICS  

    The strain induced by a multilayered structure affects how strongly unit cells are distorted to form structural modulations (supercell: SC in bismuth cuprate superconducting films. On the contrary to the multilayered structure, the strain will be released in a single thick film. To investigate the effect of strain oil the SC structure, a relatively thick Bi2Sr2Ca1Cu2Ox (Bi-2212 film was prepared oil a MgO(001) substrate, and the SC structure in the thick film was compared with those ill single thin film and the multilayered films. With the increase in film thickness from a few layers to a few tens of hundred layers, another phase of Bi-2212 became a dominant structure, which rotated around the Surface normal with ail angle of 32 degrees. The distortion became weak in the thick film. resulting in the weak satellite generated by the SC structure.

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  • Single domain epitaxial growth of yttria-stabilized zirconia on Si(111) substrate 査読

    S. Kaneko, K. Akiyama, T. Ito, Y. Hirabayashi, S. Ohya, T. Oguni, Y. Sawada, H. Funakubo, M. Yoshimoto

    CERAMICS INTERNATIONAL   34 ( 4 )   1047 - 1050   2008年5月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCI LTD  

    Yttria-stabilized zirconia (YSZ) was epitaxially grown on both Si(0 0 1) and Si(1 1 1) substrates using a RF magnetron sputtering method. While YSZ(0 0 1) was grown on Si(0 0 1) with a cubic on cubic relation, YSZ(1 1 1) film on Si(1 1 1) with six-fold symmetry on surface showed two variants; cubic on cubic (type A) and 180 degrees rotation about surface normal along [1 1 1] (type B). X-ray diffraction method confirmed single domain YSZ with type B structure when samples were prepared with the relatively slow deposition rate and low substrate temperature. Interestingly, in a reverse pairing of substrate and film, Si deposited on YSZ(1 1 1) substrates showed single domain with type A structure. (c) 2007 Elsevier Ltd and Techna Group S.r.l. All rights reserved.

    DOI: 10.1016/j.ceramint.2007.09.087

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  • Structural modulation in bismuth cuprate superconducting film with continuous epitaxial growth 査読

    Satoru Kaneko, Kensuke Akiyama, Takeshi Ito, Yoshitada Shimizu, Yasuo Hirabayashi, Seishiro Ohya, Hiroshi Funakubo, Mamoru Yoshmioto

    JOURNAL OF CRYSTAL GROWTH   310 ( 7-9 )   1713 - 1717   2008年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE BV  

    X-ray reciprocal space mapping (XRSM) revealed asymmetric intensity distribution of satellite peaks, caused by structural modulation, so-called supercell (SC), of the bismuth cuprate film Bi2Sr2Ca1Cu2Ox (Bi-2212). How unit cells are distorted to form SC is investigated on multilayered structure, which induces extra strain into unit cells. In order to investigate the effect of displacement of relatively heavy bismuth on intensity and distribution of SC peaks on XRSM, modulation waves were applied into not the whole crystal but to specified atoms constructing structural modulation as a simple crystal model, and the simulation was compared to the experimental results. To the contrary to multilayer, in this study, relatively thick films were prepared, which released the strain in its single layer. Epitaxial growth was verified by X-ray diffraction with relation of 32 degrees rotation with respect to the surface normal of the initial epitaxial Bi-2212 film. (C) 2007 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.jcrysgro.2007.11.071

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  • Effect of strain on supercell structure of bismuth cuprate superconducting film 査読

    Satoru Kaneko, Kensuke Akiyama, Masahiko Mitsuhashi, Takeshi Ito, Masao Kuniagai, Hiroshi Funakubo, Mamoru Yoshimoto

    JAPANESE JOURNAL OF APPLIED PHYSICS   47 ( 1 )   664 - 666   2008年1月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:JAPAN SOC APPLIED PHYSICS  

    The multilayered structure of bismuth cuprate superconducting film (Bi(2)Sr(2)Ca(1)Cu(2)O(X)/Bi(2)Sr(2)Cu(1)O(X)) affects the supercell consisting of several unit cells as well as the lattice constant of each layer. A relatively thick film of epitaxial Bi(2)Sr(2)Ca(1)Cu(2)O(X) (Bi-2212) was prepared to determine its crystal structure and to compare with a reference film of similar to 1000 angstrom thickness and a multilayered structure. As the Bi-2212 film grew continuously, the film was rotated by 32 degrees around the surface normal with respect to the initial layer of Bi-2212. The angle can be interpreted according to the coincidence site lattice (CSL) with E 17 and 18.

    DOI: 10.1143/JJAP.47.664

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  • In-plane rotated crystal structure in continuous growth of bismuth cuprate superconducting film 査読

    Satoru Kaneko, Kensuke Akiyama, Takeshi Ito, Yasuo Hirabayashi, Hiroshi Funakubo, Mamoru Yoshimoto

    THEORY, MODELING AND NUMERICAL SIMULATION OF MULTI-PHYSICS MATERIALS BEHAVIOR   139   53 - +   2008年

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    記述言語:英語   掲載種別:研究論文(国際会議プロシーディングス)   出版者・発行元:TRANS TECH PUBLICATIONS LTD  

    Bismuth cuprate superconductor has a unique structure called a structural modulation (supercell, SC) consisting of modulated several unit cells. Strain induced by multilayered structure increases the intensity of SC modulation, while an oxygen deficient sample shows expansion of SC size. In this study, as opposed to the multilayer strain, by preparing samples with thick film thicknesses the effect of strain on crystal structure was investigated including SC structure. Epitaxial growth was verified by x-ray diffraction, and the thicker film showed other epitaxial phase rotated 32 degrees around the surface normal with respect to the initial epitaxial phase. The SC size estimated by x-ray reciprocal space mapping was double the size of the initial epitaxial phase. Interestingly, the initial epitaxial phase became a dominant structure after further deposition. In order to evaluate the different SC size and SC modulation, a new index related with an incline of the modulation vector was proposed.

    DOI: 10.4028/www.scientific.net/SSP.139.53

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  • Characterization of a microfluidic device fabricated using a photosensitive sheet 査読

    Takeshi Ito, Taku Kawaguchi, Hiroko Miyoshi, Kenichi Maruyama, Satoru Kaneko, Seishiro Ohya, Yuzuru Iwasaki, Osamu Niwa, Koji Suzuki

    Journal of Micromechanics and Microengineering   17 ( 3 )   432 - 438   2007年3月

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    掲載種別:研究論文(学術雑誌)  

    We investigated the characteristics of microfluidic devices fabricated using photosensitive sheets adhered to substrates. We evaluated them in regard to practical criteria, namely chemical resistance, pressure sealing, electrical resistance and elution of ions. No samples exhibited peeling after postbaking when we investigated the adhesion characteristics by dicing. The sheet swelled dramatically on exposure to an alkaline solution. The microfluidic devices consisting of photosensitive sheet sandwiched by two Pyrex substrates and a photosensitive sheet sandwiched by two PMMA substrates had a pressure sealing of 0.6 MPa, were capable of withstanding a pressure of 0.2 MPa for 1 h when ultrapure water was injected. The sheets had a high volume resistivity (9.7 × 1012 Ω cm) and a high surface resistivity (2.3 × 1011 Ω) after postbaking. Sodium ions were adsorbed onto the photosensitive sheet and then gradually desorbed. The total amount of sodium ion elution per unit area over 24 h was 8.3 × 10-9 mol mm -2 as measured by ion exchange chromatography. These results confirm that microfluidic devices fabricated using photosensitive sheets are suitable for use as disposable devices for certain applications. © 2007 IOP Publishing Ltd.

    DOI: 10.1088/0960-1317/17/3/003

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  • Microfluidic device for the detection of glucose using a micro direct methanol fuel cell as an amperometric detection power source

    Takeshi Ito, Masayuki Kunimatsu, Satoru Kaneko, Seishiro Ohya, Koji Suzuki

    ANALYTICAL CHEMISTRY   79 ( 4 )   1725 - 1730   2007年2月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER CHEMICAL SOC  

    We designed and prepared a novel microbiosensing system consisting of a microbioreactor fabricated using photosensitive sheets intercalated between Pyrex wafers as a dam structure, together with a micro fuel cell as a power source device between the electrodes for amperometric detection. The dam structure retains enzyme (glucose oxidase, GOx)-immobilized microbeads in a microchannel. Microelectrodes are used as an integrated detector within a microchannel located downstream of the dam structure, and these are used to detect the oxidation current of hydrogen peroxide produced from a glucose sample and GOx. A micro direct methanol fuel cell (mu-DMFC, i.d. 500 mu m) was fabricated on a polymeric substrate and was used to supply a potential for the electrochemical detector. In this case, two mu-DMFCs were stacked on one substrate to increase the voltage for the oxidation of hydrogen peroxide. A linear response curve was obtained in range from 0.1 to 10 mM glucose for the designed microbiosensing system. These results show that a microfluidic biosensing system designed with a mu-DMFC device is useful and has the potential to assist minuaturization and simplification of the sensing system, in addition to increasing disposability of the device.

    DOI: 10.1021/ac0618167

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  • Twin-free epitaxial films lateral relation between YSZ(111) and Si(111) 査読

    Satoru Kaneko, Kensuke Akiyama, Taku Oguni, Takeshi Ito, Yasuo Hirabayashi, Seishiro Ohya, Koichi Seo, Yutaka Sawada, Hiroshi Funakubo, Mamoru Yoshimoto

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS   45 ( 46-50 )   L1328 - L1330   2006年12月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INST PURE APPLIED PHYSICS  

    Yttria-stabilized zirconia (YSZ) films were prepared on Si(I 11) substrates with a slow deposition rate. X-ray diffraction clearly showed epitaxial growth of YSZ(111) film on Si(111), the X-ray phi scan of 3-fold symmetry confirmed single domain YSZ(111) to be rotated 180 degrees about the surface normal from cubic on cubic relation. In contrast, single domain Si(111) films showed cubic on cubic relation with the YSZ(111) substrate.

    DOI: 10.1143/JJAP.45.L1328

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  • Characteristics of micro DMFCs array fabricated on flexible polymeric substrate

    T Ito, K Kimura, M Kunimatsu

    ELECTROCHEMISTRY COMMUNICATIONS   8 ( 6 )   973 - 976   2006年6月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:ELSEVIER SCIENCE INC  

    We propose a novel design and fabrication technique for a micro direct methanol fuel cell (mu-Direct methanol fuel cells (DMFC)). Ten mu-DMFCs were fabricated on a polymeric flexible substrate containing a micro-holes array (empty set = 500 mu m). Our concept is that a high voltage DMFC can be achieved through the integration of a micro DMFC array on one flexible substrate. With 10 cells in series on the substrate, we achieved an open circuit voltage of 5.6 V and an average cell power density of 3 mW cm(-2). Further, none of the cells failed after subjecting the substrate to 1000 fold repetitions. Preliminary test results show that our DMFC fabricated on a polymeric substrate is useful as a miniature DMFC. (C) 2006 Elsevier B.V. All rights reserved.

    DOI: 10.1016/j.elecom.2006.03.044

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  • Fabrication of high performance polymeric microfluidic device by a simple imprinting method using a photosensitive sheet 査読

    Takeshi Ito, Taku Kawaguchi, Hiroko Miyoshi, Kenichi Maruyama, Aki Honda, Satoru Kaneko, Seishiro Ohya, Osamu Niwa, Kouichi Terasaka, Koji Suzuki

    Japanese Journal of Applied Physics, Part 2: Letters   45 ( 1-3 )   2006年1月

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    掲載種別:研究論文(学術雑誌)  

    We describe a low cost and high performance fabrication process to make a polymeric microfluidic device. The original microfluidic device pattern was made of a flat photosensitive sheet in which a mold base device was fabricated using the combined techniques of both electroforming and photolithography. As an example of our novel process, an electrophoresis chip was prepared using poly(methyl methacrylate) (PMMA) for a DNA analysis. The result shows that the fabricated chip has an equivalent DNA separation performance when compared to a similar ready-made product. © 2006 The Japan Society of Applied Physics.

    DOI: 10.1143/JJAP.45.L64

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  • Modulation derived satellite peaks in x-ray reciprocal mapping on bismuth cuprate superconductor film 査読

    S Kaneko, Y Shimizu, K Akiyama, T Ito, M Mitsuhashi, S Ohya, K Saito, H Funakubo, M Yoshimoto

    APPLIED PHYSICS LETTERS   85 ( 12 )   2301 - 2303   2004年9月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:AMER INST PHYSICS  

    X-ray reciprocal space mapping (XRSM) was employed to investigate epitaxial Bi2Sr2Ca1Cu2Ox(Bi-2212) film. Ordinal cross section XRSM (omega-2theta) and plan view XRSM (omega-psi) clearly indicated asymmetric intensity distribution of four satellite peaks caused by supercell structure of Bi-2212 film. Modulation vector estimated by XRSM was q=0.2b(*)+0.9c(*). The XRSM image simulated by sawtooth wave vector showed good agreement with asymmetric satellite peaks observed on epitaxial film. (C) 2004 American Institute of Physics.

    DOI: 10.1063/1.1794376

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  • Effect of buffer layer on epitaxial growth of YSZ deposited on Si substrate by slower Q-switched 266 nm YAG laser 査読

    S Kaneko, K Akiyama, Y Shimizu, T Ito, S Yasaka, M Mitsuhashi, S Ohya, K Saito, T Watanabe, S Okamoto, H Funakubo

    JAPANESE JOURNAL OF APPLIED PHYSICS PART 1-REGULAR PAPERS SHORT NOTES & REVIEW PAPERS   43 ( 4A )   1532 - 1535   2004年4月

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    記述言語:英語   掲載種別:研究論文(学術雑誌)   出版者・発行元:INST PURE APPLIED PHYSICS  

    Yttria-stabilized zirconia (YSZ) was grown on Si (100) substrate by pulsed laser deposition (PLD). The laser used in this study was a 266 nm YAG laser with a second function generator modulating only the Q-switch while the primary generator modulated the flash lamp (slower Q-switch). Epitaxial growth was verified on YSZ film deposited without oxygen gas followed by primary deposition in oxygen atmosphere on Si substrate with a similar to0.4-nm-thin oxide layer. The crystallinity was strongly dependent on the thickness of the buffer layer deposited prior to the primary deposition of YSZ. The epitaxial growth was confirmed by phi scan, and omega scan (rocking curve) showed the full width at half maximum (FWHM) of 1.1 deg. The required oxygen pressure for epitaxial growth was quite high compared to that of excimer deposition.

    DOI: 10.1143/JJAP.43.1532

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  • Epitaxial Yttria-stabilized Zirconia (YSZ) film deposited on Si(100) substrate by YAG laser 査読

    Satoru Kaneko, Kensuke Akiyama, Takeshi Ito, Hiroyasu Yuasa, Shinji Yasaka, Masahiko Mitsuhashi, Yoshitada Shimizu, Seishiro Ohya, Keisuke Saito, Takayuki Watanabe, Shoji Okamoto, Hiroshi Funakubo

    Shinku/Journal of the Vacuum Society of Japan   47 ( 7 )   581 - 584   2004年

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    記述言語:英語   出版者・発行元:Vacuum Society of Japan  

    The fourth harmonic of Q-switched YAG was used to deposit yttria-stabilized zirconia (YSZ) film on Si(100) substrate. A secondary function generator was employed to modulate Q-switch while the primary generator was synchronized with flash lamps to decrease repetition rate of laser beam. At rate of 2 Hz, beam energy increased ∼ 50% per pulse. YSZ film was deposited on Si(100) using 3 mol% YSZ sintered pellet and ∼ 9 mol% single crystal YSZ as targets. In order to improve crystallinity of YSZ, two-step deposition was also carried out
    deposition in oxygen insufficient atmosphere followed by oxygen sufficient atmosphere. The full width at half maxim (FWHM) of rocking curve showed ∼1.4° for the film produced by two-step deposition on Si substrate with thin SiO2 layer using single crystal YSZ as a target.

    DOI: 10.3131/jvsj.47.581

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▼全件表示

書籍等出版物

  • ストレス、疲労の計測・センシング技術とその評価

    ( 担当: 共著 範囲: QCMバイオセンサーによるストレス関連生体物質の簡易・高速検出)

    情報技術協会  2019年 

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  • 天然系抗菌・防カビ剤の開発と応用

    ( 担当: 共著 範囲: ナノ構造に起因する抗菌・殺菌効果)

    CMC出版  2019年 

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  • Analysis of Food Toxins and Toxicants

    ( 担当: 共著 範囲: Detection of Histamine Based on Biosensor System)

    Wiley & Sons Ltd  2017年 

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  • パワーエレクトロニクス実装に向けた高耐熱接合技術

    篠原 俊朗, 伊藤 健, 八坂 慎一

    工業材料  2012年 

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  • 組み換えヒスタミンオキシダーゼを用いたヒスタミン・センサー

    廣井 哲也, 伊藤 健

    農産物・食品検査法の新展開 第Ⅲ編 食品鮮度および機能測定法、CMC出版  2010年 

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MISC

  • Newly developed chemical probes and nano-devices for cellular analysis

    Aki Honda, Hirokazu Komatsu, Dai Kato, Akio Ueda, Kenichi Maruyama, Yuzuru Iwasaki, Takeshi Ito, Osamu Niwa, Koji Suzuki

    Analytical Sciences   24 ( 1 )   55 - 66   2008年1月

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    掲載種別:書評論文,書評,文献紹介等  

    A cellular analyzing system including a "real-time cellular imaging system" and a "comprehensive analyzing system for cellular responses" was developed. A "real-time cellular imaging system" is a system used to measure real-time imaging of multiple phenomena of a single cell with high special and temporal resolutions for the purpose to understand the pathology and physiology in a single cell and realize to single cell level diagnosis. A "real-time cellular imaging system" includes multi-probe imaging with AFM (atomic force microscopy), optical and SECM (scanning electrochemical microscopy) modes, which provides us with topological information and biochemical reactions at the local area of the interior and exterior of a cell. Scanning electrochemical/optical microscopy was applied to image PC12 cells. On the other hand, cells respond to their specific substances via their ligands. Therefore, the comprehensive analysis of protein-protein interaction is the important issue to determine the functions of cells. For this purpose, a "comprehensive analysis system for cellular responses" was developed. This system is based on SPR (surface plasmon resonance) and MS (mass spectrometry) using a nano-fabricated substrate. The interaction between IL-1β and anti-IL-1β antibodies was detected. 2008 © The Japan Society for Analytical Chemistry.

    DOI: 10.2116/analsci.24.55

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  • 貫通型マイクロエアブリッジヒータを用いた熱式風速計の試作(チップスケール風洞型風速計):(チップスケール風洞型風速計)

    八坂 慎一, 大屋 誠志郎, 三橋 雅彦, 金子 智, 伊藤 健, 菅野 洋一, 相京 幸保, 小室 眞一, 大林 一也, 木村 光照

    電気学会論文誌E(センサ・マイクロマシン部門誌)   127 ( 4 )   241 - 246   2007年

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    記述言語:日本語   出版者・発行元:The Institute of Electrical Engineers of Japan  

    We developed a thermal anemometer using a novel sensor chip fabricated by the silicon micromachining technique. A chip scale wind tunnel on the sensor chip allowed the fluid to flow from the front to back side. Since conventional sensors using a micro-air-bridge heater were placed parallel to air flow, the heat transfer from the heater was influenced by turbulence generated from a chip edge or other micro structures. We expected that the chip scale wind tunnel bound air flow to keep regularity of heat transfer. By using the sensor chip, we produced a prototype thermal anemometer, and measured characteristics. The anemometer could measure wind velocity in the range of 0∼35m/sec. The directivity to wind direction was very symmetric at 5, 10, 15 and 20m/sec.

    DOI: 10.1541/ieejsmas.127.241

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  • “Satellite peaks amplified by modulation in bismuth cuprate thin film”

    Satoru Kaneko, Kensuke Akiyama, T. Ito, Y. Hirabayashi, K. Seo, HIROSHI FUNAKUBO, MAMORU YOSHIMOTO

    Physica C,   463-465   935 - 938   2007年

  • Electrochemical behavior of parallel opposed dual electrode in a microchannel

    Takeshi Ito, Kenichi Maruyama, Kazuharu Sobue, Seishiro Ohya, Osamu Niwa, Koji Suzuki

    Electroanalysis   16 ( 24 )   2035 - 2041   2004年12月

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    The electrochemical behavior dependent on the microchannel depth is discussed using a parallel opposed dual electrode in the microchip. The microchannel depth was controlled easily by the thickness of the photoresist. Cyclic voltammetry (CV) was carried out with conventional mode and the generation-collection mode. High collection efficiency (max: 98%) and high current amplification (max: 5.2) were achieved without miniaturizing the dual electrode by micromachining techniques, when the microchip with the microchannel depth of 30 μm was used in the generation-collection mode at low sweep rates. Quantitative analysis was applied to electrochemically reversible species with a quicker response time of around a few seconds for the same microchannel depth on chronoamperometry (CA). We observed good linearity on the calibration plot of dopamine (2 × 10-6 - ca. 1 × 10-3 mol dm-3).

    DOI: 10.1002/elan.200303055

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  • Electrochemical response dependent with composition of parallel opposed dual electrode and flow rate in a microchannel 査読

    Takeshi Ito, Kenichi Maruyama, Osamu Niwa, Koji Suzuki

    Proceedings - Electrochemical Society   8   289 - 299   2004年

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    We proposed an electrochemical microsystem based on a parallel opposed dual electrochemical detector in a microchannel and studied its properties using potassium ferrocyanide for flow analysis with dual mode cyclic voltammetry (CV) and chronoamperometry (CA). Electrode gap was defined by the channel depth (50 μm). Using our microchip, a highly collection efficiency (Max: 99%) was achieved without miniaturizing the dual electrode by micromachining techniques, when the potential sweep rate was set to 10 mV s-1 without the continuous flow. We also obtained the higher collection efficiency of nearly 100% with a quicker response time of around a few seconds on chronoamperometry (CA). Current amplification contributed to redox cycling was observed.

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産業財産権

  • 水晶振動子の製造方法及び水晶振動子

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    出願番号:2016-029070  出願日:2016年2月

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  • 抗菌材料及びこれを備えた抗菌部材

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    出願番号:2017-200986 

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  • 抗菌材料及びこれを備えた抗菌部材

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    出願番号:2018-186538 

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受賞

  • ポスター賞

    2022年12月   日本防菌防黴学会   ナノピラーの抗微生物評価

    松本叡佳, 田中重光, 永尾寿浩, 清水智弘, 新宮原正三, 伊藤健

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  • ポスター賞

    2019年9月   応用物理学会   ナノ構造が発現する抗菌作用のリアルタイム観察の試み

    神代啓輔、増田恭介、富成征弘、田中秀吉、小嶋寛明、清水智弘、新宮原正三、伊藤健

     詳細を見る

  • 講演奨励賞受賞

    2005年9月   応用物理学会  

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共同研究・競争的資金等の研究課題

  • ナノ構造に起因する殺菌原理解明にむけた単一細胞とナノ構造界面の相互作用解析

    研究課題/領域番号:21H01773  2021年4月 - 2024年3月

    日本学術振興会  科学研究費助成事業 基盤研究(B)  基盤研究(B)

    伊藤 健, 小嶋寛明, 岩木宏明, 田中秀吉, 富成征弘, 田中重光, 永尾寿浩

      詳細を見る

    担当区分:研究代表者 

    配分額:17290000円 ( 直接経費:13300000円 、 間接経費:3990000円 )

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  • 生物に学ぶ表面構造と樹脂製抗菌・殺菌材の開発

    2020年12月 - 2023年3月

    科学技術振興機構  A-STEP  A-STEP産学共同<育成型>

    伊藤健, 小嶋寛明, 石黒斉

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    担当区分:研究代表者 

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  • ステンレス表面の改質が抗菌作用に与える影響の評価と事業化

    2020年 - 2022年

    神奈川県立産業技術総合研究所  産学公連携事業化促進研究  産学公連携事業化促進研究

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    担当区分:連携研究者 

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  • ナノ構造により発現する抗菌メカニズムの解明とその抗菌原理を用いた抗菌シートの創成

    2018年12月 - 2019年12月

    カシオ科学技術振興財団  研究助成 

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    担当区分:研究代表者 

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  • 制御可能なナノ構造を用いた微生物抗菌メカニズムの解明

    研究課題/領域番号:18K19008  2018年6月 - 2021年3月

    日本学術振興会  科学研究費助成事業 挑戦的研究(萌芽)  挑戦的研究(萌芽)

    伊藤 健, 小嶋 寛明, 新宮原 正三, 清水 智弘

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    配分額:6110000円 ( 直接経費:4700000円 、 間接経費:1410000円 )

    セミやトンボなどの翅には無数のナノ構造が表面を埋め尽くしており、その表面は抗菌性を示すことが近年報告された。本研究では、その抗菌メカニズムを解明するために、人工的に様々な条件を制御したナノ構造を作製し、構造や物理化学的性質と抗菌との関係を明らかにしようとしている。
    初年度は、安価かつ大面積にナノ構造を作製するため、コロイダルリソグラフィとメタルアシストエッチングを用いることで2インチ角のシリコン基板に対して任意の寸法をもつ円柱状の構造物をアレイ状(ナノピラーアレイと呼ぶ)に配列させることに成功した。作製法を以下に記す。まずSi基板上にナノサイズの樹脂ビーズを単層配列させる。樹脂ビーズの直径により構造の間隔を決定できる。次に、酸素プラズマをこの基板に当てることで、樹脂ビーズを徐々に削っていく。この時の樹脂ビーズの直径がナノ構造の直径に相当する。次に、メタルアシストケミカルエッチングの際の触媒として働く金を上述した基板に薄く堆積させる。続いて、基板を特殊なエッチング溶液に浸すことでシリコン基板が深さ方向に異方的にエッチングされる。エッチング溶液に浸している時間で、ナノ構造の高さを制御することができる。最後に、金と樹脂ビーズを除去することでシリコン単体からなるナノ構造を形成することができる。この技術を用いることで任意のピッチ、直径、高さを持つナノ構造を得ることができた。
    この技術を利用して様々な幾何学的な条件を変化させたナノ構造を作製し、その基板に対して抗菌評価を実施した。抗菌評価法にはJIS Z2801(フィルム密着法)を適用し、菌体として大腸菌をターゲットに抗菌評価を行った。その結果、抗菌性を示す条件を得ることができ、特許の申請に至った。

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  • ナノ構造を利用した水晶振動子デバイスの創製とバイオセンサへの応用

    2017年 - 2018年

    村田学術振興財団  研究助成 

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    担当区分:研究代表者 

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  • 自己組織化ナノ構造を利用した抗菌性材料の開発

    2016年4月 - 2017年3月

    飯島藤十郎記念食品科学振興財団  研究助成  自己組織化ナノ構造を利用した抗菌性材料の開発

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    担当区分:研究代表者 

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  • 健康維持を目的としたコルチゾール検出ストレスセンサの開発

    研究課題/領域番号:25410164  2013年4月 - 2016年3月

    日本学術振興会  科学研究費助成事業 基盤研究(C)  基盤研究(C)

    伊藤 健, 青木 信義, 金子 智, 鈴木 孝治, チッテリオ ダニエル

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    配分額:4940000円 ( 直接経費:3800000円 、 間接経費:1140000円 )

    コルチゾールは、ストレスの経時変化を追うのに適したストレスマーカーである。本研究では個人が家庭で操作でき、「その場測定」が可能なコルチゾールの検出・測定装置を実現するための研究開発を行った。具体的には、マイクロ流体デバイス及び毛細管現象を利用したフロー系と水晶振動子マイクロバランス法のアセンブル化である。抗体の選定、競合物質の選定、再生条件の検討を行うことで、計測時間8分、再生時間5分、1測定サイクルが併せて13分となる「コルチゾールのその場計測」システムの構築を実現した。

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  • マルチナノリアクターを用いた高速食品分析システムの構築

    研究課題/領域番号:21710134  2009年 - 2010年

    日本学術振興会  科学研究費助成事業 若手研究(B)  若手研究(B)

    伊藤 健

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    配分額:4160000円 ( 直接経費:3200000円 、 間接経費:960000円 )

    食品の高速定量分析を目的としてマルチリアクター及び電気化学検出用の新規機能性電極の開発を行った。前者では、3 次元流路を持つ金型を作製し、プラスチック基板へ構造を転写する方法を確立し、1 チップに4 本のマイクロ流路を作製した。後者では、パルスレーザー堆積法を用いてNi、Pt などの金属ナノ粒子を形成した機能性電極を構築した。これらの技術を集積化してラクトースを二段階酵素反応により高速に検出することに成功した。

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社会貢献活動

  • 学術振興会 第174委員会 幹事

    2019年

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