Organization
Faculty of Chemistry, Materials and Bioengineering Associate Professor
Title
Associate Professor
External link
NAKAI,Misaki
Research History
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Kansai University Faculty of Chemistry , Materials and Bioengineering, Department of Chemistry and Materials Engineering Associate Professor
2014
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Kansai University Faculty of Chemistry , Materials and Bioengineering, Department of Chemistry and Materials Engineering Assistant Professor
2008 - 2014
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The University of Tokyo
2006 - 2008
Professional Memberships
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THE CHEMICAL SOCIETY OF JAPAN
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基礎錯体工学研究会
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ポルフィリンALA学会
Papers
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Synthesis and properties of thieno[3,2-b]thiophene appended triarylamine radical cations: Near-infrared absorbing dye with absorption beyond 1400 nm
Masafumi Yano, Kazushi Ueda, Yuto Shimizu, Yuki Arikata, Misaki Nakai, Tatsuo Yajima, Koichi Mitsudo, Yukiyasu Kashiwagi
Dyes and Pigments 111916 - 111916 2023.12
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Near-infrared absorption of a benzothiophene-appended triphenylamine radical cation: A novel molecular design of NIR-II dye
Masafumi Yano, Yoshinori Inada, Yuki Hayashi, Misaki Nakai, Koichi Mitsudo, Yukiyasu Kashiwagi
Dyes and Pigments 109929 - 109929 2021.11
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Evaluation of 99mTc-sulfonamide and sulfocoumarin derivatives for imaging carbonic anhydrase IX expression Reviewed
Misaki Nakai, Jihne Pan, Kuo-Shyan Lin, John R. Thompson, Alessio Nocentini, Claudiu T. Supuran, Yasuo Nakabayashi, Tim Storr
Journal of Inorganic Biochemistry 185 63 - 70 2018.8
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Mixed-ligand ruthenium(II) complexes capable of hydrogen-bonding interactions with DNA: DNA binding, nuclease activity, cytotoxicity, and topoisomerase inhibition Reviewed
Naho Iizuka, Misaki Nakai, Yasuo Nakabayashi
POLYHEDRON 137 34 - 42 2017.11
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Anticancer activity of heterodinuclear ruthenium(II)-platinum(II) complexes as photochemotherapeutic agents Reviewed
Takakazu Yano, Shota Hishida, Misaki Nakai, Yasuo Nakabayashi
INORGANICA CHIMICA ACTA 454 162 - 170 2017.1
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Design, synthesis, and evaluation of technetium-99m labeled sulfocoumarin and benzenesulfonamide derivatives for imaging carbonic anhydrase IX expression with single-photon emission computed tomography Reviewed
Pan Jinhe, Nakai Misaki, Lau Joseph, Storr Tim, Benard Francois, Lin Kuo-Shyan
JOURNAL OF NUCLEAR MEDICINE 57 2016.5
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DNA Interaction and Cytotoxicity of Cyclometalated Ruthenium(II) Complexes as Potential Anticancer Drugs Reviewed
Takahiro Matsui, Hiroshi Sugiyama, Misaki Nakai, Yasuo Nakabayashi
CHEMICAL & PHARMACEUTICAL BULLETIN 64 ( 3 ) 282 - 286 2016.3
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DNA interaction with dipolar ruthenium(II) ammine complexes containing 4,4 '-bipyridinium as photochemotherapeutic agents Reviewed
Yasuo Nakabayashi, Hitomi Nakamura, Yuya Kubota, Mika Morimoto, Tomotaka Kawasaki, Misaki Nakai, Osamu Yamauchi
INORGANICA CHIMICA ACTA 423 109 - 114 2014.11
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Noncovalent DNA binding and nuclease activity of mixed-ligand ruthenium(II) complexes Reviewed
Naho Iizuka, Misaki Nakai, Yasuo Nakabayashi
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 19 S788 - S788 2014.8
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DNA binding behaviors and nuclease activities of novel mixed-ligand ruthenium(II) complexes Reviewed
Naho Iizuka, Sho-ichi Motoki, Misaki Nakai, Yasuo Nakabayashi
INORGANIC CHEMISTRY COMMUNICATIONS 46 145 - 148 2014.8
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Solvolysis and cytotoxicity of dinuclear ruthenium(II)-2,2 '-bipyridine complexes with various bridged-ligands Reviewed
Takeshi Yamada, Yukiko Noguchi, Misaki Nakai, Osamu Yamauchi, Yasuo Nakabayashi, Takaji Sato, Yusuke Tamai, Masahiko Chikuma, Yoshiki Mino
INORGANICA CHIMICA ACTA 394 190 - 195 2013.1
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Syntheses, structures, and photochemical properties of (μ3-O) tris {bis(μ-carboxylato)}trimanganese complexes with naphthylacetate ligands with relevance to artificial solar energy-harvesting systems Reviewed
Misaki Nakai, Takuzo Funabiki, Chikara Ohtsuki, Masafumi Harada, Akio Ichimura, Rika Tanaka, Takanori Nishioka, Isamu Kinoshita, Masahiro Mikuriya, Jiamo Guo, Hiroaki Benten, Hideo Ohkita, Shinzaburo Ito, Makoto Obata, Yasuo Nakabayashi, Shigenobu Yano
Inorganica Chimica Acta 406 130 - 137 2013
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Synthesis and photodynamic properties of maltohexaose-conjugated porphyrins Reviewed
Yuji Mikata, Minako Shibata, Yasuko Baba, Toyoji Kakuchi, Misaki Nakai, Shigenobu Yano
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES 16 ( 11 ) 1177 - 1185 2012.11
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Syntheses, Characterization, and Antitumor Activities of Platinum(II) and Palladium(II) Complexes with Sugar-Conjugated Triazole Ligands Reviewed
Shigenobu Yano, Hiromi Ohi, Mizue Ashizaki, Makoto Obata, Yuji Mikata, Rika Tanaka, Takanori Nishioka, Isamu Kinoshita, Yuko Sugai, Ichiro Okura, Shun-ichiro Ogura, Justyna A. Czaplewska, Michael Gottschaldt, Ulrich S. Schubert, Takuzo Funabiki, Keiko Morimoto, Misaki Nakai
CHEMISTRY & BIODIVERSITY 9 ( 9 ) 1903 - 1915 2012.9
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Synthesis of Glucopyranosyl Schiff Base Zinc(II) Complexes Capable of Interacting with Mononucleotides, and Their DNA-Cleavage Activities Reviewed
Misaki Nakai, Hironobu Fukuda, Shigenobu Yano, Yasuo Nakabayashi
CHEMISTRY & BIODIVERSITY 9 ( 9 ) 1942 - 1954 2012.9
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Synthesis and characterization of novel cyclometalated iridium(III) complexes for nanocrystalline TiO2-based dye-sensitized solar cells Reviewed
Yoshiki Shinpuku, Fumiaki Inui, Misaki Nakai, Yasuo Nakabayashi
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY 222 ( 1 ) 203 - 209 2011.7
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Integrated Palladium-Catalyzed Arylation of Heavier Group 14 Hydrides Reviewed
Aldes Lesbani, Hitoshi Kondo, Yusuke Yabusaki, Misaki Nakai, Yoshinori Yamanoi, Hiroshi Nishihara
CHEMISTRY-A EUROPEAN JOURNAL 16 ( 45 ) 13519 - 13527 2010
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Surface bottom-up fabrication of porphyrin-terminated metal complex molecular wires with photo-electron conversion properties on ITO Reviewed
Mariko Miyachi, Makiko Ohta, Misaki Nakai, Yoshihiro Kubota, Yoshinori Yamanoi, Tetsu Yonezawa, Hiroshi Nishihara
CHEMISTRY LETTERS 37 ( 4 ) 404 - 405 2008.4
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Observation of electrochemical single-electron-transfer events of gold nanoparticles in aqueous solution in the presence of both ammonium and sulfonate surface-active agents Reviewed
Misaki Nakai, Yoshinori Yamanoi, Yoshihiko Nishimori, Tetsu Yonezawa, Hiroshi Nishihara
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 47 ( 35 ) 6699 - 6702 2008
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Structure and photochemical properties of (mu-alkoxo)bis(mu-carboxylato)diruthenium complexes with naphthylacetate Ligands Reviewed
M Nakai, T Funabiki, C Ohtsuki, M Harada, A Ichimura, R Tanaka, Kinoshita, I, M Mikuriya, H Benten, H Ohkita, S Ito, M Obata, S Yano
INORGANIC CHEMISTRY 45 ( 7 ) 3048 - 3056 2006.4
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Synthesis and insulin-mimetic activities of metal complexes with 3-hydroxypyridine-2-carboxylic acid Reviewed
M Nakai, F Sekiguchi, M Obata, C Ohtsuki, Y Adachi, H Sakurai, C Orvig, D Rehder, S Yano
JOURNAL OF INORGANIC BIOCHEMISTRY 99 ( 6 ) 1275 - 1282 2005.6
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Synthesis and insulinomimetic activities of novel mono- and tetranuclear oxovanadium(IV) complexes with 3-hydroxypyridine-2-carboxylic acid Reviewed
M Nakai, M Obata, F Sekiguchi, M Kato, M Shiro, A Ichimura, Kinoshita, I, M Mikuriya, T Inohara, K Kawabe, H Sakurai, C Orvig, S Yano
JOURNAL OF INORGANIC BIOCHEMISTRY 98 ( 1 ) 105 - 112 2004.1
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Electro- and photochemical properties of a (mu-alkoxo) bis(mu-carboxylato) diruthenium complex having two tetraphenylporphinato zinc(II) moieties Reviewed
M Obata, N Tanihara, M Nakai, M Harada, S Akimoto, Yamazaki, I, A Ichimura, Kinoshita, I, M Mikuriya, M Hoshino, S Yano
DALTON TRANSACTIONS ( 20 ) 3283 - 3287 2004
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Shigenobu Yano, Misaki Nakai, Fumi Sekiguchi, Makoto Obata, Masako Kato, Motoo Shiro, Isamu Kinoshita, Masahiro Mikuriya, Hiromu Sakurai, Chris Orvig
Chemistry Letters ( 9 ) 916 - 917 2002.9
MISC
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Cytotoxicity of palladium(II) complexes with 1,10-phenanthroline derivatives and dithiocarbamate as DNA intercalators
Masashige Fujii, Hideaki Furusawa, Kana Kondo, Naho Iizuka, Misaki Nakai, Takaji Sato, Yoshiki Mino, Yasuo Nakabayashi
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 19 S786 - S787 2014.8
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Antitumor activity of heterodinuclear ruthenium(II)-platinum(II) complexes as photochemotherapeutic agents
Takakazu Yano, Misaki Nakai, Yasuo Nakabayashi
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 19 S786 - S786 2014.8
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Misaki Nakai, Tomohiro Maeda, Tsuyoshi Mashima, Shigenobu Yano, Shiho Sakuma, Eriko Otake, Akimichi Morita, Yasuo Nakabayashi
Journal of Porphyrins and Phthalocyanines 17 ( 12 ) 1173 - 1182 2013.12
Presentations
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Antitumor activities of the Pt(II) and Pd(II) complexes with terpyridine as topoisomerase inhibitors Invited International conference
Misaki Nakai, Koyo Shimada, Kohei Asano, Laurenzo De Vera Alba, Yasuhiro Funahashi, Shigenobu Yano, Yasuo Nakabayashi
The 26th International SPACC Symposium 2019.12
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ポリピリジンPt(IV)錯体の合成と光照射下でのDNAとの相互作用
野間 智寛, 石川 典, 中井 美早紀, 矢野 重信, 中林 安雄
第５２回酸化反応討論会 2019.11
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Antitumor Activity of Polypyridine Co(III) Complexes against Hypoxia Tumor and their Solution Reaction with Ascorbic Acid International conference
Misaki Nakai, Yusuke Shimonaka, Akitsugu Hayashi, Shigenobu Yano, Akihiro Nomoto, Akiya Ogawa, Yasuo Nakabayashi
19th International Conference on Biological Inorganic Chemistry 2019.8
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Synthesis of Polypyridine Co(III) Complexes and Antitumor Activities Against Hypoxia Tumor International conference
Nakai Misaki
the 15th International Symposium on Applied Bioinorganic Chemistry (ISABC15) 2019.6
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Syntheses of Polypyridine Co(III) Complexes and Cytotoxicity Evaluation against Hypoxia Tumor Cells International conference
Daiki Nagata, Yusuke. Shimonaka, Misaki Nakai, Shigenobu Yano, Aakihiro Nomoto, Akiya Ogawa, Yasuo Nakabayashi
The 29th Symposium on Role of Metals in Biological Reactions, Biology and Medicine 2019.5
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Syntheses and Photodynamic Effect of π-Extended Porphyrins with Carboxyl Group International conference
Nakai Misaki, Tomoyuki Nakagawa, Yuta Iwasaki, Shigenobu Yano, Yasuo Nakabayashi
The 29th Symposium on Role of Metals in Biological Reactions, Biology and Medicine 2019.5
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カルボキシル基連結π拡張型ポルフィリンのPDT効果と活性酸素種による細胞毒性の影響
中川智之, 岩崎雄大, 中井美早紀, 矢野重信, 中林安雄
第51回酸化反応討論会 2018.11
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Syntheses and antitumor activities of carbonate Co(III) complexes as hypoxia activated prodrug
Misaki Nakai, Akitsugu Hayashi, Yusuke Shimonaka, Shigenobu Yano, Akiya Ogawa, Yasuo Nakabayashi
43rd International Conference on Coordination Chemistry, 2018.8
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ターピリジン化合物を有する白金(II)・パラジウム(II)錯 体の抗がん活性とtopoisomerase阻害活性評価
嶋田光陽, 浅埜恭平, 中井美早 紀, 矢野重信, 舩橋靖博, 中林安雄
第68回錯体化学討論会 2018.7
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Synthesis of Glucosamine-Conjugated Metal Complexes for Anticancer and Anti-Metastatic Targeted Therapy
○Laurenzo De Vera ALBA, Tsubasa HATANAKA, Misaki NAKAI, Shigenobu YANO, Yasuhiro FUNAHASHI
第68回錯体化学討論会 2018.7
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プロドラッグとしてのCo(III)錯体の合成と低酸素腫瘍細胞への抗がん作用
下中雄介, 林晃嗣, 中井美早紀, 矢野重信, 小 川昭弥, 中林安雄
第68回錯体化学討論会 2018.7
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プロドラッグとしてのポリピリジンCo(III)錯体の合成と低酸素腫瘍への抗がん作用
中井美早紀, 林 晃嗣, 下中 雄介, 矢野 重信, 小川 昭弥, 中林 安雄
第28回金属の関与する生体関連反応シンポジウム 2018.6
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Syntheses and biodistribution of 99mTc-sulfonamide and sulfocoumarin derivatives toward molecular imaging in tumor hypoxia
Misaki Nakai, Jihne Pan, Kuo-Shyan Lin, John R. Thompson, Alessio Nocentini, Claudiu T. Supuran, Yasuo Nakabayashi, Tim Storr
The 24th International SPACC Symposium (SPACC24) 2017.11
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Carbonate Co(III) complexes with polypyridine ligand as hypoxia Activated prodrug
Akitsugu Hayashi, Yusuke Shimonaka, Misaki Nakai, Shigenobu Yano, Akiya Ogawa, Yasuo Nakabayashi
The 24th International SPACC Symposium (SPACC24) 2017.11
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カルボキシル基を有する長波長吸収ポルフィリンの活性酸素発生能評価と抗がん作用
中井美早紀, 中川智之, 岩崎雄大, 東野涼, 矢野重信, 小川昭弥, 中林安雄
第50回酸化反応討論会 2017.11
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ターピリジン配位子を有する白金(II),パラジウム(II)錯体のDNAへの相互作用と抗がん活性評価
中井美早紀, 浅埜恭平, 嶋田光陽, 矢野重信, 三方裕司, 中林安雄
第67回錯体化学討論会 2017.9
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PDT製剤を目指したp拡張型金属ポルフィリン誘導体の光学特性評価
岩崎雄大, 東野涼, 中井美早紀, 矢野重信, 中林安雄
第49回酸化反応討論会 2016.11
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Syntheses and Photodynamic activities of p-expanded porphyrin derivatives
Misaki Nakai, Yuta Iwasaki, Ryo Higashino, Shigenobu Yano, Ryan Clarke, Tim Storr, Yasuo Nakabayashi
4th International ALA and Porphyrin Symposium 2016.11
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Syntheses of far-red-absorbing porphyrin derivatives and photodynamic antitumor activities
Y. iwasaki, R. Higashino, M. Nakai, R. Clarke, T. Storr, S. Yano, Y. Nakabayashi
Pacifichem 2015 2015.12
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Syntheses of Re and 99mTc CAIX inhibitors cancer diagnositcs
Misaki Nakai, Jinhe Pan, Kou-Syan Lin, John R. Thompson, Yasuo Nakabayashi, Tim Storr
Pacifichem 2015 2015.12
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Syntheses of far-red absorbing porphyrin derivatives and DNA photocleavage activities
Misaki Nakai, Yuta Iwasaki, Ryo Higashino, Shigenobu Yano, Tim Storr, Yasuo Nakabayashi
CanBIC-5 2015.5
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Syntheses and photo-dynamic properties of the glucopyranoside? conjugated indium porphyrins
M.Nakai, T.Maeda, S.Yano, S.Sakuma, E.Otake, A. Morita, Y.Nakabayashi
1st International ALA and Porphyrin Symposium 2013.10
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Syntheses of Glucopyranoside Conjugated Schiff base Zinc(II) Complexes and their Cytotoxicites Invited
Misaki Nakai, Hironobu Fukuda, Aoi Takamatsu, Naho Izuka, Shigenobu Yano, Yasuo Nakabayashi
20 th International SPACC-CSJ Symposium 2013.9
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Syntheses of Pd(II) Terpyridine Complexes and their Interaction with DNA
M.Nakai, R.Kitamura, Y. nakabayashi
20 th International SPACC-CSJ Symposium 2013.9
Awards
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Okabe賞
2017.6 ポルフィリンALA学会
中井 美早紀
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Lecture award
2008.11 15th SPACC-CSJ Symposium
Nakai Misaki
Research Projects
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レドックス制御と低酸素部位指向性配位子設計による固形がん用プロドラッグ錯体の開発
Grant number：20K05533 2020.4 - 2023.3
日本学術振興会 科学研究費助成事業 基盤研究(C)
中井 美早紀, 矢野 重信, 小倉 俊一郎
Grant amount：\4420000 （ Direct Cost: \3400000 、 Indirect Cost：\1020000 ）
本研究の目的はCo(III)錯体の酸化還元電位の精密制御および低酸素部位蓄積性官能基の導入による低酸素腫瘍細胞高選択性次世代Co(III)錯体プロドラッグの開発である。昨年度はTris(2-pyridylmethyl)amine配位子を持つCo(III)錯体の開発を行ったが、いずれも抗がん活性を示さなかったため、ポリピリジンCo(III)錯体の合成と、その還元的雰囲気下での挙動の検討を行った。低酸素状態で細胞毒性が期待できるポリピリジルCo(III)錯体4つの水溶液中およびTris緩衝液中でのアスコルビン酸存在下での挙動を紫外可視吸収分光法で検討したところ、アスコルビン酸との反応が速いCo(III)錯体がもっとも低酸素腫瘍状態に対して細胞毒性が高いことが判明した。一方ポリピリジルCo(III)錯体の酸化還元電位にはそれほど大きく影響しないことが判明した。上記の結果は、効果的なCo(III)錯体をドラッグデザインする上で重要な見地である。
一方で、蛍光性配位子を持つCo(III)錯体の合成を検討するために、4-hydroxycoumarinを出発物質として３段階で、クマリン部位をもつアセチルアセトン配位子の合成に成功した。現在はこの配位子を持つポリピリジンCo(III)錯体の合成の検討を行っている。
今年度は、引き続きクマリン部位を持つCo(III)錯体の合成、並びにCo(III)錯体並びに低酸素部位蓄積性官能基である2-ニトロイミダゾールを持つCo(III)錯体の合成を予定している。さらに、昨年度新たに合成したポリピリジルCo(III)錯体の細胞毒性についても検討を行う。 -
Development of dual functional glycoconjugated photosensitive supra molecules for advanced photodynamic therapy and photodynamic diagnosis.
Grant number：25288028 2013.4 - 2016.3
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
YANO Shigenobu, KATAOKA Hiromi, NARUMI Atsushi, NOMOTO Akihiro, NAKAI Misaki, AKASHI Haruo
Grant amount：\18590000 （ Direct Cost: \14300000 、 Indirect Cost：\4290000 ）
Photodynamic therapy (PDT) has attracted much attention as a less invasive method for treating cancer. We have carried out in isolation and characterization of the third generation glycoconjugated chlorins and fullerenes for the advanced photodynamic therapy and photodynamic diagnosis (PDD) as described follows, 1) antitumor effects in gastrointestinal stromal tumors using photodynamic therapy with a novel glucose-conjugated chlorin, 2) a novel photodynamic therapy targeting cancer cells and tumor-associated macrophages, 3) efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy, 4) maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility etc.
Devising educational methods
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機器分析演習を受け持っており、各測定機器から得られたデータを解析できるようになるのが目的の授業である。授業中には、最新の研究でそれらの測定機器がどのように使われているのかをパワーポイントなどを利用して授業で紹介している。座学だけでなく、最新の研究でどのように測定機器が使われるのかを紹介し、学生が最新の研究と私の授業に興味を持たせるように工夫している。
Teaching materials
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特になし
Teaching method presentations
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特になし
Special notes on other educational activities
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北陽中学校連携プログラムに参加