担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.17106/jbr.37.44

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.17106/jbr.37.64

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担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

DOI： 10.11239/jsmbe.60.149

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その他リンク： https://search.jamas.or.jp/link/ui/2023127141

記述言語：英語   掲載種別：研究論文（学術雑誌）  

There are no small-diameter, long artificial vascular grafts for below-knee bypass surgery in chronic limb-threatening ischemia. We have developed tissue-engineered vascular grafts called "Biotubes®" using a completely autologous approach called in-body tissue architecture (iBTA). This study aimed at pre-implantation evaluation of Biotube and its in vivo preparation device, Biotube Maker, for use in below-knee bypass surgery. Forty nine makers were subcutaneously embedded into 17 goats for predetermined periods (1, 2, or 3 months). All makers produced Biotubes as designed without inflammation over all periods, with the exception of a few cases with minor defects (success rate: 94%). Small hole formation occurred in only a few cases. All Biotubes obtained had an inner diameter of 4 mm and a length of 51 to 52 cm with a wall thickness of 594 ± 97 μm. All Biotubes did not kink when completely bent under an internal pressure of 100 mmHg and did not leak without any deformation under a water pressure of 200 mmHg. Their burst strength was 2409 ± 473 mmHg, and suture retention strength was 1.75 ± 0.27 N, regardless of the embedding period, whereas tensile strength increased from 7.5 ± 1.3 N at 1 month to 9.7 ± 2.0 N at 3 months with the embedding period. The amount of water leakage from the needle holes prepared in the Biotube wall was approximately 1/7th of that in expanded polytetrafluoroethylene vascular grafts. The Biotubes could be easily connected to each other without cutting or anastomosis leaks. They could be stored for at least 1 year at room temperature. This study confirmed that even Biotubes formed 1 month after embedding of Biotube Makers had properties comparable to arteries.

DOI： 10.1002/jbm.b.35084

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Objective: There is a need for small diameter vascular substitutes in the absence of available autologous material. A small diameter, long tissue engineered vascular graft was developed using a completely autologous approach called "in body tissue architecture technology (iBTA)". The aim of this pilot study was to evaluate "Biotubes", iBTA induced autologous collagenous tubes, for their potential use as small diameter vascular bypass conduits. Methods: Biotubes (internal diameter 4 mm, length 50 cm, wall thickness 0.85 mm) were prepared by subcutaneous embedding of plastic moulds (Biotube Maker) in three goats for approximately two months. Allogenic Biotubes (length 10 cm [n = 2], 15 cm [n = 2], 22 cm [n = 2]) were bypassed to both carotid arteries by end to side anastomosis with their ligation between the anastomoses in another three goats. Residual Biotubes were examined for their mechanical properties. After four weeks, the harvested Biotubes were evaluated histologically. Results: All Biotubes had sufficient pressure resistance, approximately 3000 mmHg. Although wall thickening occurred at two proximal anastomosis sites, all six grafts were patent without luminal thrombus formation, stenosis, or aneurysm deformation throughout the implantation period. Endothelial cells covered both anastomosis sites almost completely, with partial covering in the central portion of the grafts. Furthermore, α smooth muscle actin positive cells infiltrated the middle layer along almost the entire graft length. Conclusion: This preliminary study showed that small diameter, long, tissue engineered Biotubes could function properly as arterial bypass conduits in a large animal for one month without any abnormal change in vascular shape. Thus, small diameter, long Biotubes are potentially viable conduits, which are biocompatible and labour non-intensive, and therefore, suitable for clinical practice. Additionally, Biotubes can start the regeneration process in a short period of time.

DOI： 10.1016/j.ejvsvf.2022.01.004

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担当区分：責任著者   記述言語：英語   出版者・発行元：公益社団法人 日本生体医工学会  

DOI： 10.11239/jsmbe.59.146

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その他リンク： http://id.ndl.go.jp/bib/031983181

掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/kidneydial1010002

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：Wiley  

BACKGROUND: Pancreatic juice reflux to the common bile duct and gallbladder is observed in the pancreaticobiliary maljunction (PBM), and various pathological conditions occur in the biliary tract. However, the mechanism of pancreatic juice reflux has not been discussed yet. This study aimed to investigate the mechanism of this phenomenon from the perspective of the fluid dynamics theory. METHODS: A fluid dynamics model of PBM without biliary dilatation having gallbladder function and of the pressure of sphincter of Oddi was developed. Water (as bile juice and pancreatic juice) was flowed to these models with a flow rate similar to that in humans. Pancreatic and bile juice flow and bile duct pressure were observed in three phases of gallbladder function. Moreover, the same experiment was performed in the PBM without biliary dilatation model without gallbladder. RESULTS: Pancreatic juice reflux could be observed when the gallbladder was passively expanded with the pressure in the bile duct lower than that in the sphincter of Oddi. However, pancreatic juice reflux was not observed in the model without gallbladder. CONCLUSIONS: Gallbladder function may be strongly involved in pancreatic juice reflux in PBM without biliary dilatation. Cholecystectomy may be able to stop the reflux of pancreatic juice.

DOI： 10.1002/jhbp.714

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その他リンク： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jhbp.714

掲載種別：研究論文（学術雑誌）   出版者・発行元：Japanese Society of Biorheology  

DOI： 10.17106/jbr.34.47

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.17106/jbr.32.20

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER JAPAN KK  

The treatment of large or wide-necked cerebral aneurysms is extremely difficult, and carries a high risk of rupture, even when surgical or endovascular methods are available. We are developing novel honeycomb microporous covered stents for treating such aneurysms. In this study, 3 experimental animal models were designed and evaluated quantitatively before preclinical study. The stents were prepared using specially designed balloon-expandable stents (diameter 3.5-5.0 mm, length 16-28 mm) by dip-coating to completely cover their struts with polyurethane film (thickness 20 mu m) and microprocessing to form the honeycomb pattern after expansion. (1) In an internal carotid artery canine model (n = 4), all stents mounted on the delivery catheter passed smoothly through the tortuous vessel with minimal arterial damage. (2) In an the large, wide-necked, outer-side-wall aneurysm canine model, almost all parts of the aneurysms had embolized immediately after stenting (n = 4), and histological examination at 2 months revealed neointimal formation with complete endothelialization at all stented segments and entirely organized aneurysms. (3) In a perforating artery rabbit model, all lumbar arteries remained patent (n = 3), with minimal change in the vascular flow pattern for over 1 year, even after placement of a second, overlapping stent (n = 3). At 2 months after stenting, the luminal surface was covered with complete thin neointimal formation. Excellent embolization performance of the honeycomb microporous covered stents without disturbing branching flow was confirmed at the aneurysms in this proof-of-concept study.

DOI： 10.1007/s10047-015-0879-0

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：ELSEVIER SCIENCE BV  

Objectives: To evaluate the functionality of an autologous heart valve with stent (Stent-biovalve or SBV) after implantation in the pulmonic valve position in beagle dogs.
Animals: Five beagle dogs.
Methods: A mold with an aperture of a tri-leaflet structure was constructed from a pair of concave and convex rods to which a nitinol (NiTi) stent was mounted. This mold was embedded in a dorsal subcutaneous pouch in beagle dogs for 4 weeks. At the time of the removal, the surfaces of the molds were completely covered with connective tissues, tri-leaflet valves were formed and the NiTi stent was tightly connected to the structure.
Results: The mean burst strength of the SBV leaflet was 2710 mmHg (range 2280-3116 mmHg), which was approximately equal to that of the native pulimonic valve leaflet. After implantation in the pulmonary position, the SBV showed good functionality as a pulmonic valve. At 84 days after implantation, the SBV was replaced with autologous fibroblasts and collagenous tissues, and showed organization similar to that of native heart valves.
Conclusion: Stent-Biovalves achieved good valvular function with laminar flow in the pulmonic valve position of beagle dogs. (C) 2015 Elsevier B.V. All rights reserved.

DOI： 10.1016/j.jvc.2014.12.003

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担当区分：責任著者   記述言語：日本語   出版者・発行元：一般社団法人 日本生体医工学会  

An erythrocyte can be deformed very easily by even small amounts of stress, enabling it to flow smoothly through approximately 3μm diameter microvessels despite its larger size of 8μm in diameter and 2μm in thickness. Reduction of erythrocyte deformability leads to poor circulation particularly in microvessels, which may result in hypertension and various circulatory diseases. To clarify blood microcirculatory properties, it is very important to understand the deformability of erythrocytes. However, a standard method for quantitative evaluation of erythrocyte deformability has not yet been established. In this study, an apparent Young's modulus and a time constant for the recovery of erythrocyte shape following uniaxial stretching are proposed as deformability indices. When an erythrocyte was pulled horizontally on opposite ends using two micropipettes, tensile stress and strain were measured, and an apparent Young's modulus was calculated based on Hooke's law. On returning to its initial shape after the erythrocyte was released from stretching, the elapsed time and strain were measured, and a time constant for shape recovery was calculated based on the Kelvin model. The average apparent Young's modulus was 16.0 Pa, and the average time constant was 113.4 ms, with a slight tendency toward an inverse relation between the two physical quantities.

DOI： 10.11239/jsmbe.53.1

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その他リンク： http://hdl.handle.net/10112/8962

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

In-body tissue architecturea novel and practical regeneration medicine technologycan be used to prepare a completely autologous heart valve, based on the shape of a mold. In this study, a three-dimensional (3D) printer was used to produce the molds. A 3D printer can easily reproduce the 3D-shape and size of native heart valves within several processing hours. For a tri-leaflet, valved conduit with a sinus of Valsalva (Biovalve type VII), the mold was assembled using two conduit parts and three sinus parts produced by the 3D printer. Biovalves were generated from completely autologous connective tissue, containing collagen and fibroblasts, within 2 months following the subcutaneous embedding of the molds (success rate, 27/30). In vitro evaluation, using a pulsatile circulation circuit, showed excellent valvular function with a durability of at least 10 days. Interposed between two expanded polytetrafluoroethylene grafts, the Biovalves (N=3) were implanted in goats through an apico-aortic bypass procedure. Postoperative echocardiography showed smooth movement of the leaflets with minimal regurgitation under systemic circulation. After 1 month of implantation, smooth white leaflets were observed with minimal thrombus formation. Functional, autologous, 3D-shaped heart valves with clinical application potential were formed following in-body embedding of specially designed molds that were created within several hours by 3D printer. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1-11, 2015.

DOI： 10.1002/jbm.b.33186

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担当区分：筆頭著者,　最終著者,　責任著者   記述言語：日本語   出版者・発行元：可視化情報学会  

ヒト血液の有形成分のほとんど全てを占める赤血球について，特に微小循環能の観点から，その変形特性を理解するだけで無く，それを診断に応用することは有用である．本研究では，マイクロ流体システムを用いて，生体内で生じうる変形を赤血球に与え，そこからの形状回復過程を可視化計測することで，個々の赤血球粘弾性特性を形状回復時定数として調べた．人為的に膜特性や内包ヘモグロビン溶液濃度を変更した血球に対して形状回復時定数を測定したところ，これらの物性の変化を標準年弾性力学モデルに対応する時定数の変化として捕らえられることを確認した．また各献体における形状回復時定数は，体内での加齢の影響を受け対数正規分布を示したことから，その幾何平均値と標準偏差相当値を用いて，糖尿病患者や腎症患者を例に，形状回復時定数との関係について調べた結果を紹介すると共に，本手法によって得られる情報の可能性について紹介した．

DOI： 10.3154/jvs.34.134_16

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

DOI： 10.11239/jsmbe.51.397

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その他リンク： http://id.ndl.go.jp/bib/025346140

担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/photonics11090892

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.3390/bioengineering11060598

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担当区分：筆頭著者,　最終著者,　責任著者   記述言語：日本語   出版者・発行元：一般社団法人 日本人工臓器学会  

DOI： 10.11392/jsao.52.189

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

DOI： 10.11239/jsmbe.58.230

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その他リンク： http://id.ndl.go.jp/bib/031339462

掲載種別：研究論文（学術雑誌）  

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記述言語：英語  

DOI： 10.5963/BER0203002

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：SPRINGER JAPAN KK  

Using simple, safe, and economical in-body tissue engineering, autologous valved conduits (biovalves) with the sinus of Valsalva and without any artificial support materials were developed in animal recipients' bodies. In this study, the feasibility of the biovalve as an aortic valve was evaluated in a goat model. Biovalves were prepared by 2-month embedding of the molds, assembled using two types of specially designed plastic rods, in the dorsal subcutaneous spaces of goats. One rod had three projections, resembling the protrusions of the sinus of Valsalva. Completely autologous connective tissue biovalves (type VI) with three leaflets in the inner side of the conduit with the sinus of Valsalva were obtained after removing the molds from both terminals of the harvested implants with complete encapsulation. The biovalve leaflets had appropriate strength and elastic characteristics similar to those of native aortic valves; thus, a robust conduit was formed. Tight valvular coaptation and a sufficient open orifice area were observed in vitro. Biovalves (n = 3) were implanted in the specially designed apico-aortic bypass for 2 months as a pilot study. Postoperative echocardiography showed smooth movement of the leaflets with little regurgitation under systemic circulation (2.6 +/- A 1.1 l/min). alpha-SMA-positive cells appeared significantly with rich angiogenesis in the conduit and expanded toward the leaflet tip. At the sinus portions, marked elastic fibers were formed. The luminal surface was covered with thin pseudointima without thrombus formation. Completely autologous biovalves with robust and elastic characteristics satisfied the higher requirements of the systemic circulation in goats for 2 months with the potential for valvular tissue regeneration.

DOI： 10.1007/s10047-012-0679-8

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担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/kikaib.79.992

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その他リンク： https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670628/

担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：日本エム・イー学会  

DOI： 10.11239/jsmbe.51.52

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その他リンク： http://search.jamas.or.jp/link/ui/2013308582

出版者・発行元：循環器病研究の進歩  

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s12573-012-0052-9

DOI： 10.1007/s12573-012-0054-7

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担当区分：筆頭著者,　責任著者   記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：HINDAWI PUBLISHING CORPORATION  

A miniaturized fiber-optic laser Doppler velocimetry sensor has been developed to measure the local blood velocity in vivo. The laser beam emitted from the sensor tip can be focused at any distance between 0.1 and 0.5mm from the tip. Consequently, the sensor has a sufficiently high signal-to-noise ratio to measure the local velocity in almost any opaque fluid, including blood. The sensor head is inserted in an injection needle or a catheter tube. In the former case, it is inserted at an angle to the wall of a vessel and is scanned across the vessel to measure the velocity distribution. In the latter case, it is aligned parallel with the flow in a vessel. For all flows of whole human blood, whole caprine blood, and 69% hematocrit of bovine blood, the velocity distribution across the vessel could be measured very accurately. The insertion angle of the fiber into the flow significantly affects the measurement accuracy; an angle of about 50. is suitable when an injection needle is used. When a catheter is employed, an insertion direction opposite to the flow direction is better than parallel to the flow due to the generation of a wake behind the fiber.

DOI： 10.1155/2012/426476

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その他リンク： https://dblp.uni-trier.de/db/journals/js/js2012.html#TajikawaIKO12

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-BLACKWELL  

In-body tissue, architecture technology represents a promising approach for the development of living heart valve replacements and preparation of a series of biovalves. To reduce the degree of regurgitation and increase the orifice ratio, we designed a novel mold for a type VI biovalve. The mold had an outer diameter of 14 mm for implantation in beagles, and it was prepared by assembling two silicone rods with a small aperture (1 mm) between them. One rod had three protrusions of the sinus of Valsalva, whereas the other was almost cylindrical. When the molds were embedded in the subcutaneous pouches of beagles for 1 month, the native connective tissues that subsequently developed covered the entire outer surface of the molds and migrated into the aperture between the rods. The mold from both sides of the harvested cylindrical implant was removed, and homogenous well-balanced trileaflets were found to be separately formed in the open form with a small aperture at the three commissure parts inside the developed conduit, which had a thick homogenous wall even in the sinus of Valsalva. Exposure of the obtained biovalves to physiological aortic valve flow in beagles revealed proper opening motion with a wide orifice area. The closure dynamics were suboptimal, probably due to the reduction in the size of the sinus of Valsalva. The mechanical behavior of this biovalve might allow its use as a living aortic valve replacement. (C) 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 99B: 135-141, 2011.

DOI： 10.1002/jbm.b.31880

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記述言語：英語   掲載種別：研究論文（国際会議プロシーディングス）  

The concept of micro-electro-mechanical systems (MEMS) sensors directly fabricated on a ceramic substrate, which can be used for a package of end product, was proposed. As demonstrations of the sensors directly fabricated on a ceramic package, an accelerometer and a magnetoresistive (MR) sensor are focused on, and their fabrications on a ceramic substrate is investigated. The accelerometer utilizes a fringe capacitance formed in a ferroelectric material. For this sensor, in stead of a previously used bulk PZT plate, a screen-printed BaTiO3 (BTO) film on a ceramic alumina substrate was herein employed. An accelerometer using a BTO film was practically fabricated. The sensitivity of it was estimated as 0.1 pF/g, which is degraded a little compare with the previously developed accelerometer using a PZT plate
however, the order is the same. The magnetoresistive (MR) sensor can detect not only x- and y-axes magnetic field intensities but also z-axis one, where all fields are based on the sensor coordinate system. Namely, not only azimuth but also angle of elevation of the sensor can be detected from triaxis components of geomagnetic field. The principle is as follows: a permalloy (FeNi) plate is stood aside MR element. The plate distorts magnetic field and generates x- (or y-) component from originally z-directional field. So, the resistance of MR element changes in proportional to z-axis field intensity, provided that other axes intensities are kept constant. © 2011 by ASME.

DOI： 10.1115/IPACK2011-52290

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Background-: We developed autologous prosthetic implants by simple and safe in-body tissue architecture technology. We present the first report on the development of autologous valved conduit with the sinus of Valsalva (BIOVALVE) by using this unique technology and its subsequent implantation in the pulmonary valves in a beagle model. Methods and results-: A mold of BIOVALVE organization was assembled using 2 types of specially designed silicone rods with a small aperture in a trileaflet shape between them. The concave rods had 3 projections that resembled the protrusions of the sinus of Valsalva. The molds were placed in the dorsal subcutaneous spaces of beagle dogs for 4 weeks. The molds were covered with autologous connective tissues. BIOVALVEs with 3 leaflets in the inner side of the conduit with the sinus of Valsalva were obtained after removing the molds. These valves had adequate burst strength, similar to that of native valves. Tight valvular coaptation and sufficient open orifice area were observed in vitro. These BIOVALVEs were implanted to the main pulmonary arteries as allogenic conduit valves (n=3). Postoperative echocardiography demonstrated smooth movement of the leaflets with trivial regurgitation. Histological examination of specimens obtained at 84 days showed that the surface of the leaflet was covered by endothelial cells and neointima, including an elastin fiber network, and was formed at the anastomosis sides on the luminal surface of the conduit. Conclusion-: We developed the first completely autologous BIOVALVE and successfully implanted these BIOVALVEs in a beagle model in a pilot study. © 2010 American Heart Association, Inc.

DOI： 10.1161/CIRCULATIONAHA.109.922211

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

DOI： 10.1007/s10047-010-0491-2

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/kikaib.76.772_2111

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その他リンク： https://www.jstage.jst.go.jp/article/kikaib1979/76/772/76_KJ00006813222/_pdf

記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-LISS  

The aim of this study was to prepare completely autologous heart-valve-shaped constructs without using any artificial scaffold materials by in-body tissue architecture technology, which is a practical concept of regenerative medicine based on the biological defense mechanism against foreign bodies. Silicone rods were used as molds to achieve the tubular shape of the arteries, which were implanted in the subcutaneous spaces of rabbits. After 2 weeks of primary in-body tissue incubation, the silicone rods were completely encapsulated within a thin membranous connective tissue mainly consisting of collagen and having a thickness of similar to 100 mu m. To achieve the trileaflet shape of the valve, the cylindrical tissues obtained were rolled up with polyurethane belts cut in the shape of three semi-ovals. The assembled tissues were reimplanted for 2 weeks for secondary incubation. The resulting tissues were over-encapsulated with the newly developed membranous connective tissue having a thickness of similar to 200-400 mu m. The newly formed membranes were completely fused to the previously developed inner membrane. After the removal of the two artificial materials, tubular constructs with trileaflet-shaped internal surface were obtained. By controlling the formation of the encapsulating tissue in the two-step in-body tissue incubation process, we were able to develop completely autologous trileaflet valve-shaped constructs. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 91B: 813-818, 2009

DOI： 10.1002/jbm.b.31460

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

DOI： 10.11239/jsmbe.47.28

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その他リンク： http://id.ndl.go.jp/bib/10225996

担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：関西大学  

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担当区分：責任著者   記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

DOI： 10.11239/jsmbe.47.36

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その他リンク： http://id.ndl.go.jp/bib/10226007

記述言語：英語   出版者・発行元：SPRINGER TOKYO  

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担当区分：筆頭著者,　責任著者   記述言語：英語   出版者・発行元：The Japan Society of Mechanical Engineers  

A new miniaturized fiber-optic laser Doppler velocimetry (LDV) sensor has been developed, which is capable of measuring the local velocity in various semi-opaque and opaque fluid flows, particularly whole blood velocity in vessels. The sensor has a convex lens-like fiber tip as a pickup and an improved optical transmission system with markedly decreased stray light. This paper describes methods for fabricating fiber tips like concave and convex lens and the characteristics of the optical sensor system equipped with the fabricated fiber tip. Conventional fiber-optic LDV sensors developed up to now have not been capable of measuring such opaque fluids because scattered light from scattering particles as erythrocytes has very low intensity, which makes signal-to-noise ratio of Doppler signal received by a sensor pickup significantly decreased. To overcome these problems, convex lens-like fiber tips have been fabricated by chemical etching, in which quartz fibers of multimode graded refractive index have been etched in aqueous solutions of hydrogen fluoride and ammonium fluoride under the appropriately controlled condition of the concentration of the solution, the etching duration time and the etchant temperature to obtain the desired curvature radius of the lens-like surface of the fiber tip. In this fiber-optic sensor, a laser beam emitted from the fiber tip can be focused at any position from about 0.1 to 0.5 mm distant from the fiber tip according to its curvature radius. The convex lens-like etched tip totally reduced the intensity of undesired reflecting light at the fiber end by 1/2 to 1/6 compared with normal cut fiber tip. Consequently, this fiber-optic LDV sensor system is capable of measuring the local flow velocity in semi-opaque and opaque fluids, whose turbidity was about five times higher than by any kinds of previous sensors.

DOI： 10.1299/jfst.4.62

CiNii Books

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記述言語：英語   掲載種別：研究論文（学術雑誌）   出版者・発行元：WILEY-LISS  

As a practical concept of regenerative medicine, we have focused on in vivo tissue engineering utilizing the foreign body reaction. Plastic substrates for valvular leaflet organization, consisting of two pieces assembled with a small aperture were inserted into a microporous polyurethane conduit scaffold. The assembly was placed in the subcutaneous spaces of Japanese white rabbits for 1 month. After the substrates were pulled out from the harvested implant, valve leaflet-shaped membranous tissue was formed inside the tubular scaffold as designed. The valve leaflet was composed of the same collagen-rich tissue, with the absence of any elastic fiber, as that which had ingrown or covered the scaffold. No abnormal collection or infiltration of inflammatory cells in the leaflet and the scaffold could be demonstrated. According to the immunohistochemical staining, the leaflet was comprised of numerous vimentin- or alpha-SMA-positive cells, corresponding to fibroblasts or myofibroblats, but contained no desmin-positive cells. The analysis of the video data of the valve movement showed that, in synchronization with the backward flow in the diastolic phase, the valve closed rapidly and tightly and, in the transition phase of the flow direction, the valve opened smoothly without flapping or hitting the scaffold wall. Using mold designs, consisting of two different plastic substrates and the tubular scaffold, in conjunction with "in body tissue architecture," the complex 3-dimensional autologous conduit-typed Biovalve was developed for the first time. (C) 2007 Wiley Periodicals, Inc.

DOI： 10.1002/jbm.b.30981

Web of Science

PubMed

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記述言語：英語   掲載種別：研究論文（学術雑誌）  

Web of Science

PubMed

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記述言語：日本語   出版者・発行元：公益社団法人 日本生体医工学会  

DOI： 10.11239/jsmbe.45.298

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記述言語：日本語   出版者・発行元：サーキュレーション アップトゥデート  

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担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：東京 : 日本機械学会 ; 1979-2010  

DOI： 10.1299/kikaib.73.231

DOI： 10.1143/jjap.48.017002_references_DOI_NXnIust42sG6TfUhpBwZ5SN6nAE

CiNii Books

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その他リンク： http://id.ndl.go.jp/bib/8663747

担当区分：責任著者   記述言語：日本語   出版者・発行元：関西大学  

関西大学学術フロンティアプロジェクト「ナノ・サブマイクロ技術を用いた模擬／人工生体組織の創製と新診断・治療法の開発」 20030401-20080331

DOI： 10.1299/kikaib.72.1702

CiNii Books

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記述言語：日本語   出版者・発行元：社団法人 可視化情報学会  

DOI： 10.3154/jvs.26.supplement2_93

CiNii Books

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その他リンク： https://ndlsearch.ndl.go.jp/books/R000000004-I8857670

担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：The Visualization Society of Japan  

科研費若手研究 （B） 20030401-20050331

DOI： 10.3154/tvsj.25.84

CiNii Books

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担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：社団法人日本生体医工学会  

関西大学学術フロンティアプロジェクト「ナノ・サブマイクロ技術を用いた模擬／人工生体組織の創製と新診断・治療法の開発」 20030401-20080331

DOI： 10.11239/jsmbe.43.638

CiNii Books

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その他リンク： http://search.jamas.or.jp/link/ui/2006156902

担当区分：責任著者   記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

文部科学省学術フロンティア推進事業 2003-0401-

DOI： 10.1299/kikaib.71.2092

Scopus

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担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/kikaib.69.2431

Scopus

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その他リンク： http://www.jstage.jst.go.jp/article/kikaib1979/69/687/69_687_2431/_pdf

担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：東京 : 日本機械学会 ; 1979-2010  

DOI： 10.1299/kikaib.67.1338

Scopus

CiNii Books

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その他リンク： http://id.ndl.go.jp/bib/5817652

担当区分：筆頭著者,　責任著者   記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/kikaib.67.67

Scopus

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その他リンク： http://www.jstage.jst.go.jp/article/kikaib1979/67/653/67_653_67/_pdf

記述言語：日本語  

CiNii Books

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その他リンク： http://id.ndl.go.jp/bib/029199074

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本バイオレオロジー学会  

DOI： 10.11262/jpnbr.35.1_4

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記述言語：日本語   出版者・発行元：吹田 : 関西大学先端科学技術推進機構  

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その他リンク： http://id.ndl.go.jp/bib/030539135

記述言語：日本語   出版者・発行元：吹田 : 関西大学先端科学技術推進機構  

CiNii Books

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その他リンク： http://id.ndl.go.jp/bib/029841009

記述言語：日本語   出版者・発行元：吹田 : 関西大学先端科学技術推進機構  

CiNii Books

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その他リンク： http://id.ndl.go.jp/bib/029199074

記述言語：日本語   出版者・発行元：関西大学先端科学技術推進機構  

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本バイオレオロジー学会  

DOI： 10.11262/jpnbr.30.3_153

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本バイオレオロジー学会  

DOI： 10.11262/jpnbr.30.3_156

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J-GLOBAL

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記述言語：日本語   出版者・発行元：関西大学先端科学技術推進機構  

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記述言語：日本語   出版者・発行元：日本混相流学会  

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記述言語：日本語   出版者・発行元：一般社団法人日本機械学会  

DOI： 10.1299/jsmemag.117.1146_286_2

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記述言語：日本語   出版者・発行元：特定非営利活動法人 日本バイオレオロジー学会  

DOI： 10.11262/jpnbr.28.3_148

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記述言語：日本語   出版者・発行元：社団法人 可視化情報学会  

DOI： 10.3154/jvs.33.6

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記述言語：日本語   出版者・発行元：関西大学  

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出版者・発行元：生体医工学  

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記述言語：日本語   出版者・発行元：関西大学  

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記述言語：日本語   出版者・発行元：関西大学  

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記述言語：日本語   出版者・発行元：Japanese Society of Biorheology  

DOI： 10.11262/jpnbr.24.1_3

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記述言語：日本語   出版者・発行元：関西大学  

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記述言語：日本語   出版者・発行元：関西大学  

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記述言語：日本語   出版者・発行元：一般社団法人 日本機械学会  

DOI： 10.1299/jsmemag.111.1074_388_6

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記述言語：日本語   出版者・発行元：関西大学  

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J-GLOBAL

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記述言語：日本語   出版者・発行元：関西大学  

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記述言語：日本語   出版者・発行元：関西大学  

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記述言語：日本語   出版者・発行元：関西大学  

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J-GLOBAL

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記述言語：日本語   出版者・発行元：関西大学  

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記述言語：日本語   出版者・発行元：社団法人 可視化情報学会  

DOI： 10.3154/jvs.24.supplement1_21

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その他リンク： https://ndlsearch.ndl.go.jp/books/R000000004-I7706915

記述言語：日本語   出版者・発行元：関西大学  

CiNii Books

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記述言語：日本語   出版者・発行元：社団法人 可視化情報学会  

DOI： 10.3154/jvs.19.supplement2_237

CiNii Books

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その他リンク： http://id.ndl.go.jp/bib/4871017

記述言語：日本語   出版者・発行元：社団法人 可視化情報学会  

DOI： 10.3154/jvs.18.supplement2_47

CiNii Books

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その他リンク： http://id.ndl.go.jp/bib/4571899

開催年月日： 2022年

記述言語：日本語  

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開催年月日： 2022年

記述言語：日本語  

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開催年月日： 2021年

記述言語：日本語  

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開催年月日： 2021年

記述言語：日本語  

我々の研究グループでは，生体内組織形成術(iBTA)を用いて心臓弁様組織体(バイオバルブ)を開発してきた．先行研究においては，iBTAで作製される膜状組織体（バイオシート，以下BS）を弁尖として，僧帽弁の人工弁輪を模倣した楕円状リングを土台として縫い付けた新しい概念の人工弁を試作し，弁機能を評価してきた．しかしながら，弁の構造により弁開口性能と閉鎖性能を両立させることが難しかった．本研究は，新たに異方性を有した膜状の弁尖を試作し，先行研究と同様の簡易型人工弁を作製することで，弁尖の力学的異方性が弁機能におよぼす影響を調べた． 弁機能評価では，作製した生体外模擬実験装置を使い，実験条件はヒト生理条件とした．BSの作製には約2ヶ月必要なため，BSを使って実験することは効率が悪い．そこで今回はBSと力学特性が違いポリウレタン製シート(以下PS)を使用し，等間隔かつ平行にならべたNi-Ti線を2枚のPSで挟み込み，熱加工でPS同士を融着させ，それを所望の形状と大きさに切り出すことで異方性を有する弁尖モデルとした．実験では，弁尖の曲げ剛性が高い向きとそれを縫い付ける弁輪の位置関係および，人工弁輪を模したリングに対する弁尖はみ出し量<i>e</i>＝0~3mmを変化させ，各条件において左心房圧と左心室圧，僧帽弁位流量を測定し，人工弁の国際規格であるISO5840に基づき，弁閉鎖性能として逆流率<i>Rf</i>，弁開口性能として平均圧較差Δ <i>p</i>，有効開口面積<i>EOA</i>を評価した．

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開催年月日： 2020年12月

記述言語：日本語  

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その他リンク： http://id.ndl.go.jp/bib/031339462

開催年月日： 2020年

記述言語：日本語  

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開催年月日： 2020年

記述言語：日本語  

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開催年月日： 2020年

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開催年月日： 2020年

記述言語：日本語  

これまで我々の研究グループでは，生体自身を培養器として利用し様々な立体形状を有する結合組織体を作製する生体内組織形成術（以下，iBTA）を用いて，人工血管，心臓弁などの再生に取り組んできた．中でも，心臓代用弁としてのバイオバルブは，主に動脈弁としての開発を行ってきたが，房室弁形状のバイオバルブは対象となる弁の形状が複雑であり，特に弁尖が腱索によって心室壁と繋がる構造的な複雑性を有することから，移植難易度が高いといった問題点があり実用化には至っていない．そこで本研究では，この問題点を解決する簡易型人工房室弁の開発を目標として，簡易的な形状を有しながらも，弁閉鎖時に弁尖の裏返りなどの逸脱が生じにくい形状として，人工弁輪を兼ねた金属製のステントにシート状の結合組織を縫い付けることで，ヒンジを有する様なバタフライバルブ形状の人工弁を試作した．この弁を，研究室で開発した左心シミュレータを用いて，ヒト左心系の生理条件を模した条件下で実験を行うことで，逆流率，EOA，圧隔差などの弁血行力学的特性を測定・評価した．また，バイオシートと力学的に相似なポリウレタンシートを使い，その厚みやシート切り出し形状を変化させることで，弁形状の違いが弁機能におよぼす影響を系統的に調べることで，設計の最適化を試みた．

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開催年月日： 2019年1月

記述言語：日本語  

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その他リンク： http://id.ndl.go.jp/bib/030658804

開催年月日： 2019年

記述言語：日本語  

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記述言語：日本語  

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開催年月日： 2018年1月

記述言語：日本語  

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その他リンク： http://id.ndl.go.jp/bib/029314879

開催年月日： 2018年

記述言語：日本語  

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開催年月日： 2016年6月

開催地：東京  

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開催地：東京  

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開催地：富山  

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記述言語：日本語  

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開催地：寝屋川  

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開催年月日： 2016年1月

開催地：東京  

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開催年月日： 2016年1月

記述言語：日本語  

We have been developing microporous covered stents (MCSs) for the treatment of giant and wide neck intracranial aneurysms (IAs). By shielding IA neck with the microporous cover film, blood flow in IA was stagnated immediately. Subsequently, IA embolization is occurred by thrombus formation with a remarkable decrease of shear rate in IA flow. So, flow reduction performance of device placing is closely related to capability of IA embolization. In this study, we compared the flow reduction performance between MCS and flow diverter (FD), a another type stent for the IA treatment. IA flow was visualized by using in vitro flow simulator and evaluated by particle image velocimetry (PIV). Two-dimensional sidewall IA model was made from acrylic resin. Aneurysm depth, Dome size and neck width of IA model were 9.1 mm, 10.0 mm, 7.1 mm respectively. FD or MCS models were placed at the neck of the aneurysm model. Distributions of flow velocity and shear rate in IA were measured. Before stenting, high shear rate regions spread throughout IA cavity. After stenting, flow velocities in IA model stagnated remarkably. Area mean shear rate in IA flow became about 9 % by FD and 3 % by MCS. Flow reduction performance of MCS was about 3 times higher than the FD.

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開催年月日： 2016年

記述言語：日本語  

<p>In order to clarify the property of blood microcirculation, it is very important to comprehend the deformability of erythrocytes which occupy about 45 % of the blood volume. By tensile test to an erythrocyte using micropipettes in the microscope, an apparent Young's modulus was calculated based on Hooke's low and a time constant of an erythrocyte's shape recovering process was calculated based on Kelvin model as an index of its deformability. In this study, the influence of inner viscosity of erythrocytes to the physical quantities was confirmed experimentally with erythrocyte ghost of inner viscosity adjusted by using isotonic solution of dextran and so on. As a result, it was found that apparent Young's modulus was not changed by the change of inner viscosity of erythrocytes, while time constant of shape recovering was decreased, which had a good agreement with Kelvin model in changing trend of physical quantities.</p>

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開催年月日： 2016年

記述言語：日本語  

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開催年月日： 2015年11月

会議種別：ポスター発表  

開催地：東京  

第52回日本人工臓器学会大会 萌芽研究ポスター発表優秀賞 受賞 https://www.jsao.org/files/magazine/44_1/44_22.pdf

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開催年月日： 2015年11月

開催地：東京  

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開催年月日： 2015年11月

開催地：Orlando, USA  

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開催年月日： 2015年10月

開催地：京都  

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開催年月日： 2015年9月

開催地：Saporo, Japan  

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開催年月日： 2015年9月

開催地：札幌  

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開催年月日： 2015年9月

記述言語：日本語  

We have been developing microporous covered stents for a treatment of intracranial aneurysm (IA). This device promotes flow reduction and induces progressive thrombosis in IA. In this study, we investigated intra-aneurysmal flow with various curvature ratios of parent vessel by using in vitro flow simulator. Two-dimensional sidewall IA models were fabricated from acrylic plastic. Parent vessels shape were designed on a straight and U-bend shape (curvature ratio: 0, 0.125, 0.250, 0.500, 0.667) models. Reynolds number in the parent vessel flow was set between 160 and 980 in steady flow. Microporous stainless-steel sheet (pore diameter: 100 μm, porosity: 30 %) was prepared as a stent model. Distributions of velocity and shear rate of intra-aneurysmal flow were measured by particle image velocimetry. As the result, faster intra-aneurysmal flow was observed in the case of sharper bended vessel model. Area mean shear rates in the case of the U-bend vessel model (curvature ratio: 0.500) was about 5 times higher than the case of straight vessel model. After stenting, the area mean shear rates at the all IA models were decreased to about 12 % of before stenting. It is suggested that our developing microporous covered stent has a good embolization performance, if the aneurysm is created at such curved vessel.

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開催年月日： 2015年9月

開催地：Leuven, Belgian  

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開催年月日： 2015年8月 - 2015年9月

開催地：London, UK  

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開催年月日： 2015年6月

開催地：東京  

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開催年月日： 2015年6月

開催地：東京  

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開催年月日： 2015年3月

開催地：京都  

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開催年月日： 2015年3月

開催地：京都  

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開催年月日： 2015年3月

開催地：京都  

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開催年月日： 2015年2月

記述言語：日本語  

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開催年月日： 2015年1月

開催地：新潟  

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開催年月日： 2015年1月

開催地：新潟  

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開催年月日： 2015年1月

開催地：新潟  

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開催年月日： 2015年1月

記述言語：日本語  

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開催年月日： 2015年1月

記述言語：日本語  

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開催年月日： 2015年1月

記述言語：日本語  

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その他リンク： http://id.ndl.go.jp/bib/027679831

開催年月日： 2015年

記述言語：日本語  

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開催年月日： 2015年

記述言語：日本語  

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開催年月日： 2015年

記述言語：日本語  

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開催年月日： 2015年

記述言語：日本語  

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開催年月日： 2014年11月

開催地：Chicago,USA  

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開催年月日： 2014年11月

開催地：Chicago,USA  

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開催年月日： 2014年10月

開催地：札幌  

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開催年月日： 2014年10月

開催地：札幌  

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開催年月日： 2014年10月

開催地：札幌  

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開催年月日： 2014年10月

開催地：札幌  

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開催年月日： 2014年10月

開催地：札幌  

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開催年月日： 2014年9月

開催地：小金井  

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開催年月日： 2014年9月

開催地：Barcerona, Spain  

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開催年月日： 2014年9月

記述言語：日本語  

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開催年月日： 2014年8月 - 2014年9月

開催地：Barcerona, Spain  

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開催年月日： 2014年7月

開催地：Boston, USA  

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開催年月日： 2014年6月

開催地：埼玉  

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開催年月日： 2014年6月

開催地：埼玉  

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開催年月日： 2014年4月

開催地：Nice, France  

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開催年月日： 2014年4月

開催地：Nice, France  

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開催年月日： 2014年3月

開催地：堺  

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開催年月日： 2014年3月

開催地：堺  

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開催年月日： 2014年3月

開催地：堺  

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開催年月日： 2014年3月

記述言語：日本語  

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開催年月日： 2014年3月

記述言語：日本語  

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開催年月日： 2014年3月

記述言語：日本語  

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開催年月日： 2014年3月

開催地：京都  

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開催年月日： 2014年3月

開催地：京都  

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開催年月日： 2014年3月

開催地：京都  

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開催年月日： 2014年3月

開催地：京都  

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開催年月日： 2014年3月

開催地：京都  

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開催年月日： 2014年1月

開催地：吹田  

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開催年月日： 2014年1月

開催地：吹田  

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開催年月日： 2014年1月

記述言語：日本語  

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開催年月日： 2014年1月

開催地：仙台  

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開催年月日： 2014年1月

開催地：仙台  

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開催年月日： 2014年1月

開催地：仙台  

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開催年月日： 2014年1月

開催地：仙台  

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開催年月日： 2014年1月

開催地：仙台  

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開催年月日： 2014年1月

記述言語：日本語  

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開催年月日： 2014年1月

記述言語：日本語  

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開催年月日： 2014年1月

記述言語：日本語  

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開催年月日： 2014年1月

記述言語：日本語  

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開催年月日： 2014年

記述言語：日本語  

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開催年月日： 2013年12月

開催地：九十九里  

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開催年月日： 2013年11月

開催地：Dalas  

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開催年月日： 2013年11月

開催地：福岡  

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開催年月日： 2013年11月

記述言語：日本語  

The purpose of this study is elucidating the mechanism of mosquito's flight. The motion of mosquito's wings consists of three representative motion; flapping, lead-lug and feathering motion. The feathering motion is a rotational movement which is centering on a wing leading edge. The mosquitoes are performing this motion passively produced by fluid forces and so on. In order to build the enlarged model which simulates this motion, we need to measure the stiffness of the mosquito's wings. The bending stiffness of the mosquito's wings were measured by the experiment using a cantilever. The enlarged wing model was designed based on its results. We observed the flapping motion of the enlarged wing model in the very low velocity wind tunnel and verified whether the feathering motion can be simulated.

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開催年月日： 2013年11月

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開催年月日： 2013年11月

記述言語：英語  

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開催年月日： 2013年9月

開催地：横浜  

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開催年月日： 2013年9月

開催地：横浜  

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開催年月日： 2013年9月

開催地：横浜  

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開催年月日： 2013年9月

開催地：横浜  

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開催年月日： 2013年9月

開催地：岐阜  

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開催年月日： 2013年9月

開催地：福岡  

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開催年月日： 2013年9月

開催地：福岡  

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開催年月日： 2013年9月

開催地：福岡  

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開催年月日： 2013年9月

開催地：福岡  

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開催年月日： 2013年9月

開催地：岐阜  

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開催年月日： 2013年9月

開催地：Glasgow  

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開催年月日： 2013年9月

記述言語：日本語  

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開催年月日： 2013年8月

記述言語：日本語  

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開催年月日： 2013年6月

開催地：Venice  

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開催年月日： 2013年6月

開催地：福岡  

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開催年月日： 2013年6月

開催地：福岡  

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開催年月日： 2013年3月

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開催年月日： 2013年3月

開催地：横浜  

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開催年月日： 2013年3月

開催地：横浜  

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開催年月日： 2013年2月

記述言語：日本語  

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開催年月日： 2013年2月

記述言語：日本語  

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開催年月日： 2013年1月

開催地：吹田  

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開催年月日： 2013年1月

記述言語：日本語  

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開催年月日： 2013年1月

開催地：吹田  

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開催年月日： 2013年1月

開催地：つくば  

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開催年月日： 2013年1月

開催地：つくば  

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開催年月日： 2013年1月

開催地：つくば  

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開催年月日： 2013年1月

記述言語：日本語  

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開催年月日： 2013年1月

記述言語：日本語  

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開催年月日： 2013年1月

記述言語：日本語  

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開催年月日： 2013年

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開催年月日： 2012年11月

開催地：福岡  

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開催年月日： 2012年11月

開催地：福岡  

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開催年月日： 2012年11月

開催地：福岡  

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開催年月日： 2012年11月

開催地：福岡  

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開催年月日： 2012年11月

記述言語：日本語  

We have been developing a microporous covered stent as a newly device for cerebral aneurysm treatment.This stent has a porous film to control both embolization and rapid neointimal formation.It is expected that the neointimal formation becomes earlier by using much larger pores,but there is a possibility that the covered stent with large pare cannot embolize by increasing inflow from parent vessel.The purpose of this study is estimation of stent embolization and optimization of pore design to ensure compatibility between reliable embolization and controlling early neointimal formation,in-vitro experiment based on flow similarity low has been conducted by using a 2D parent vessel model with a side wall type aneurysm model.The flow visualization result shows that three kinds of flow pattern in the aneurysm were observed namely,viscous shear induced flow,pressure drop induced flow and those coexistence flow.According to PIV result,mean shear rate in the aneurysm after stenting was decreased to less than 1/10 of before stenting.

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開催年月日： 2012年11月

記述言語：日本語  

Recently,pathogenesis of aortic valve sclerosis with aging is increasing with development of the aging of the population in Japan.It has been known that endothelial injury is the first step of valvular cholesterosis and the sclerosis.This study considered that some kinds of mechanical stress caused by blood flow e.g.both wall shear stress and structural tensile/compressive stress are one of the factors of endothelial damage.Therefore,in vitro experiment for blood flow was conducted by using a realistic model of human aortic valve and cardiovascular flow simulator based on wind-kessel model and three-dimensional velocity vector distribution and wall shear stress distribution on the model surface were measured by stereo PIV.As a result,swirling flow in a Valsalva sinus model caused by inflow from a part of the jet flow through the valve opening was observed during systole Large shear stress gradient was observed on the surface of the valve basis with valve deformation at the mid systole.

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開催年月日： 2012年11月

記述言語：日本語  

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開催年月日： 2012年11月

記述言語：日本語  

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開催年月日： 2012年11月

記述言語：日本語  

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開催年月日： 2012年10月

開催地：福岡  

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開催年月日： 2012年10月

開催地：弘前  

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開催年月日： 2012年10月

開催地：弘前  

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開催年月日： 2012年10月

開催地：弘前  

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開催年月日： 2012年10月

開催地：姫路  

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開催年月日： 2012年10月

記述言語：日本語  

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開催年月日： 2012年10月

記述言語：日本語  

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開催年月日： 2012年10月

記述言語：日本語  

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開催年月日： 2012年10月

開催地：大阪  

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開催年月日： 2012年9月

開催地：盛岡  

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開催年月日： 2012年9月

記述言語：日本語  

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開催年月日： 2012年9月

記述言語：日本語  

We have been developing a micro porous covered stent as a newly device for cerebral aneurysm treatment to adapt large and giant cerebral aneurysm with a broad neck. This stent has a porous film to control among thrombus formation, rapid neointimal formation and intimal hyperplasia. It is expected that the neointimal formation becomes earlier by using much larger pores. But there is a possibility that the covered stent with large pare cannot embolize an aneurysm by increasing inflow from parent vessel. The purpose of this study is optimization of pore design to ensure compatibility between reliable embolization and controlling early neointimal formation, in-vitro experiment based on flow similarity low has been conducted by using a 2D parent vessel model with a side wall type aneurysm model. The flow visualization result shows that three kinds of flow pattern in the aneurysm were observed namely, viscous shear induced flow, pressure drop induced flow and those coexistence flow. According to PIV measurement result, area mean shear rate in the aneurysm after stenting was decreased to less than 1/5 of before stenting. Especially, when the covered stents of which aperture diameter was lower than 200μm and aperture ratio was 60% were installed, shear rate in aneurysm was less than 1 s^<-1> which was a threshold of F-IX activating necessary for venous thrombus formation.

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開催年月日： 2012年9月

開催地：豊中  

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開催年月日： 2012年9月

開催地：豊中  

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開催年月日： 2012年9月

開催地：豊中  

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開催年月日： 2012年8月

記述言語：日本語  

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開催年月日： 2012年8月

記述言語：日本語  

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開催年月日： 2012年7月

開催地：高槻  

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開催年月日： 2012年6月

開催地：横浜  

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開催年月日： 2012年6月

開催地：横浜  

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開催年月日： 2012年6月

開催地：横浜  

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開催年月日： 2012年6月

開催地：横浜  

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開催年月日： 2012年6月

開催地：埼玉  

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開催年月日： 2012年6月

記述言語：日本語  

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開催年月日： 2012年6月

記述言語：英語  

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開催年月日： 2012年5月 - 2012年6月

開催地：新潟  

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開催年月日： 2012年5月

記述言語：日本語  

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開催年月日： 2012年5月

記述言語：日本語  

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開催年月日： 2012年5月

記述言語：日本語  

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開催年月日： 2012年5月

開催地：福岡  

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開催年月日： 2012年3月

記述言語：日本語  

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開催年月日： 2012年3月

開催地：吹田  

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開催年月日： 2012年3月

開催地：吹田  

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開催年月日： 2012年3月

開催地：吹田  

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開催年月日： 2012年3月

開催地：吹田  

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開催年月日： 2012年3月

開催地：吹田  

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開催年月日： 2012年3月

開催地：吹田  

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開催年月日： 2012年3月

開催地：吹田  

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開催年月日： 2012年3月

記述言語：日本語  

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開催年月日： 2012年3月

記述言語：日本語  

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開催年月日： 2012年3月

記述言語：日本語  

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開催年月日： 2012年3月

記述言語：日本語  

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開催年月日： 2012年3月

記述言語：日本語  

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開催年月日： 2012年3月