Updated on 2024/03/30

写真a

 
NAGAOKA,Yasuo
 
Organization
Faculty of Chemistry, Materials and Bioengineering Professor
Title
Professor
Contact information
メールアドレス
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Degree

  • Ph.D ( 1996.9 )

  • 薬学修士 ( 1991.3 )

Research Interests

  • Synthetic medicinal chemistry;medicinal chemistry;

  • Synthetic medicinal chemistry

  • medicinal chemistry

Research Areas

  • Life Science / Pharmaceutical chemistry and drug development sciences

Education

  • Kyoto University   Graduate School, Division of Pharmaceutical Sciences

    - 1992

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  • Meiji Pharmaceutical University   Faculty of Pharmaceutical Science

    - 1989

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    Country: Japan

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  • Kyoto University   Graduate School, Division of Pharmaceutical Sciences

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  • Kyoto University   Graduate School, Division of Pharmaceutical Sciences

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    Country: Japan

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  • Kyoto University   Graduate School, Division of Pharmaceutical Sciences

    1992

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    Country: Japan

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Professional Memberships

Papers

  • Asymmetric Synthesis of t-Butyl 3-Alkyl-oxindole-3-carboxylates via Chiral Phosphoric Acid-Catalyzed Desymmetrization of Di-t-butyl 2-Alkyl-2-(2-aminophenyl)malonates Reviewed

    Kyoji Ishida, Masahiro Shimizu, Yusuke Yamai, Itaru Natsutani, Shinichi Uesato, Yasuo Nagaoka, Takaaki Sumiyoshi

    Heterocycles   99(2), 1398 -1411   2019.2

  • Monitoring of glutamate-induced excitotoxicity by mitochondrial oxygen consumption

    Ayako Kumagai, Tsutomu Sasaki, Kenta Matsuoka, Masayoshi Abe, Toshihide Tabata, Yumi Itoh, Hiroyuki Fuchino, Sartagul Wugangerile, Mika Suga, Tomoko Yamaguchi, Hidehisa Kawahara, Yasuo Nagaoka, Kenji Kawabata, Miho Kusuda Furue, Hiroshi Takemori

    SYNAPSE   73 ( 1 )   2019.1

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:WILEY  

    Dysfunction of mitochondrial activity is often associated with the onset and progress of neurodegenerative diseases. Membrane depolarization induced by Na+ influx increases intracellular Ca2+ levels in neurons, which upregulates mitochondrial activity. However, overlimit of Na+ influx and its prolonged retention ultimately cause excitotoxicity leading to neuronal cell death. To return the membrane potential to the normal level, Na+/K+-ATPase exchanges intracellular Na+ with extracellular K+ by consuming a large amount of ATP. This is a reason why mitochondria are important for maintaining neurons. In addition, astrocytes are thought to be important for supporting neighboring neurons by acting as energy providers and eliminators of excessive neurotransmitters. In this study, we examined the meaning of changes in the mitochondrial oxygen consumption rate (OCR) in primary mouse neuronal populations. By varying the medium constituents and using channel modulators, we found that pyruvate rather than lactate supported OCR levels and conferred on neurons resistance to glutamate-mediated excitotoxicity. Under a pyruvate-restricted condition, our OCR monitoring could detect excitotoxicity induced by glutamate at only 10 mu M. The OCR monitoring also revealed the contribution of the N-methyl-D-aspartate receptor and Na+/K+-ATPase to the toxicity, which allowed evaluating spontaneous excitation. In addition, the OCR monitoring showed that astrocytes preferentially used glutamate, not glutamine, for a substrate of the tricarboxylic acid cycle. This mechanism may be coupled with astrocyte-dependent protection of neurons from glutamate-mediated excitotoxicity. These results suggest that OCR monitoring would provide a new powerful tool to analyze the mechanisms underlying neurotoxicity and protection against it.

    DOI: 10.1002/syn.22067

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  • Efficient synthesis of t-butyl N-hydroxy-3-alkyl-oxindole-3-carboxylates from di-t-butyl 2-nitrophenyl-malonates Reviewed

    長岡 康夫, Yamai Y., Ishida K., Natsutani I., Uesato S., Nagaoka Y., Sumiyoshi T.

    Heterocycles   97   2017.12

  • SYNTHESIS OF SUBSTITUTED t-BUTYL 3-ALKYLOXINDOLE-3-CARBOXYLATES FROM DI-t-BUTYL (2-NITROPHENYL)MALONATES Reviewed

    Yu-suke Yamai, Akio Tanaka, Tatsuo Yajima, Kyoji Ishida, Itaru Natsutani, Shinichi Uesato, Yasuo Nagaoka, Takaaki Sumiyoshi

    HETEROCYCLES   97 ( 1 )   192 - 210   2017.12

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PERGAMON-ELSEVIER SCIENCE LTD  

    Using a novel tandem reduction-cyclization, we synthesized t-butyl 3-alkyloxindole-3-carboxylates from the di-t-butyl 2-alkyl-2-(2-nitrophenyl)malonate. Introduction of an alpha-substituent to the di-t-butyl 2-(2-nitrophenyl)-malonates and addition of acid promoted reactivity. This methodology was successfully applied to gram-scale-synthesis of the t-butyl 3-methyloxindole-3-carboxylate 1 and 3-hydroxyrnethy1-3-methyloxindole 2 without silica gel column chromatography.

    DOI: 10.3987/COM-17-S(T)2

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  • The Importance of 11α-OH, 15-oxo, and 16-en Moieties of 11α-Hydroxy-15-oxo-kaur-16-en-19-oic Acid in Its Inhibitory Activity on Melanogenesis

    A. Kuroi, K. Sugimura, A. Kumagai, A. Kohara, Y. Nagaoka, H. Kawahara, M. Yamahara, N. Kawahara, H. Takemori, H. Fuchino

    Skin Pharmacol. Physiol.   30(4), 205-215   2017.7

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  • Synergistic Antitumor Effect of a Combination of Paclitaxel and Carboplatin with Nobiletin from Citrus depressa on Non-Small-Cell Lung Cancer Cell Lines

    Shinichi Uesato, Hirofumi Yamashita, Ryu Maeda, Yoshiyuki Hirata, Maho Yamamoto, Saki Matsue, Yasuo Nagaoka, Makio Shibano, Masahiko Taniguchi, Kimiye Baba, Motoharu Ju-ichi

    PLANTA MEDICA   80 ( 6 )   452 - 457   2014.4

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:GEORG THIEME VERLAG KG  

    Non-small-cell lung carcinomas do not sufficiently respond to cancer chemotherapeutic drugs. Combination effects of cancer chemotherapy drugs (paclitaxel and carboplatin) with nobiletin or powdered Shiikuwasha extract from Citrus depressa were examined by isobologram and combination index analyses. It was demonstrated that the combination generated a synergistic inhibitory effect against the proliferation of the human non-small-cell lung carcinoma cell lines A549 and H460 and that of the two chemotherapy drugs, paclitaxel was responsible for this synergistic effect. Furthermore, the percentage of apoptotic cells was decreased with increasing rates of nobiletin to paclitaxel and carboplatin. These findings were considered to be attributed to the ability of nobiletin to regulate cells in the G(1) phase, which escaped cell death initiated by paclitaxel and carboplatin. An antitumor activity assay showed that this combination significantly suppressed the growth of subcutaneous A549 tumor xenografts in nude mice.

    DOI: 10.1055/s-0034-1368321

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  • Induction of melanogenesis by 40-O-methylated flavonoids in B16F10 melanoma cells

    Ippei Horibe, Yudai Satoh, Yuki Shiota, Ayako Kumagai, Nanao Horike, Hiroshi Takemori, Shinichi Uesato, Shuji Sugie, Katsuyoshi Obata, Hidehisa Kawahara, Yasuo Nagaoka

    J. Nat. Med.   2013.10

  • Induction of melanogenesis by 40-O-methylated flavonoids in B16F10 melanoma cells

    Ippei Horibe, Yudai Satoh, Yuki Shiota, Ayako Kumagai, Nanao Horike, Hiroshi Takemori, Shinichi Uesato, Shuji Sugie, Katsuyoshi Obata, Hidehisa Kawahara, Yasuo Nagaoka

    J. Nat. Med.   Published online: 04 December   2012.12

  • Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice

    Tatsuya Uebi, Yumi Itoh, Osamu Hatano, Ayako Kumagai, Masato Sanosaka, Tsutomu Sasaki, Satoru Sasagawa, Junko Doi, Keita Tatsumi, Kuniko Mitamura, Eiichi Morii, Katsuyuki Aozasa, Tomohiro Kawamura, Meinoshin Okumura, Jun Nakae, Hajime Takikawa, Toshio Fukusato, Minako Koura, Mayumi Nish, Anders Hamsten, Angela Silveira, Alejandro M. Bertorello, Kazuo Kitagawa, Yasuo Nagaoka, Hidehisa Kawahara, Takeshi Tomonaga, Tetsuji Naka, Shigeo Ikegawa, Noriyuki Tsumaki, Junichiro Matsuda, Hiroshi Takemori

    PLOS ONE   7 ( 5 )   2012.5

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    Language:English   Publishing type:Research paper (scientific journal)   Publisher:PUBLIC LIBRARY SCIENCE  

    Salt-inducible kinase 3 (SIK3), an AMP-activated protein kinase-related kinase, is induced in the murine liver after the consumption of a diet rich in fat, sucrose, and cholesterol. To examine whether SIK3 can modulate glucose and lipid metabolism in the liver, we analyzed phenotypes of SIK3-deficent mice. Sik3(-/-) mice have a malnourished the phenotype (i.e., lipodystrophy, hypolipidemia, hypoglycemia, and hyper-insulin sensitivity) accompanied by cholestasis and cholelithiasis. The hypoglycemic and hyper-insulin-sensitive phenotypes may be due to reduced energy storage, which is represented by the low expression levels of mRNA for components of the fatty acid synthesis pathways in the liver. The biliary disorders in Sik3(-/-) mice are associated with the dysregulation of gene expression programs that respond to nutritional stresses and are probably regulated by nuclear receptors. Retinoic acid plays a role in cholesterol and bile acid homeostasis, wheras ALDH1a which produces retinoic acid, is expressed at low levels in Sik3(-/-) mice. Lipid metabolism disorders in Sik3(-/-) mice are ameliorated by the treatment with 9-cis-retinoic acid. In conclusion, SIK3 is a novel energy regulator that modulates cholesterol and bile acid metabolism by coupling with retinoid metabolism, and may alter the size of energy storage in mice.

    DOI: 10.1371/journal.pone.0037803

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  • メラニン産生をコントロールする新規細胞内因子SIK2とその関連機能に影響を与えるフラボノイド誘導体 Reviewed

    長岡康夫, 熊谷彩子, 竹森 洋

    毛髪科学   110, 9-13   2012.4

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  • Anti-tumor activity of new orally bioavailable 2-amino-5-(thiophen-2-yl)benzamide-series histone deacetylase inhibitors, possessing an aqueous soluble functional group as a surface recognition domain

    Y. Hirata(D, M. Hirata, Y. Kawaratani, M. Shibano, M. Taniguchi, M. Yasuda, Y. Ohmomo, Y. Nagaoka, K. Baba, S. Uesato

    Bioorg. Med. Chem. Lett.   22(5), 1926-1930   2012.1

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  • Antitumor effect of liposomal histone deacetylase inhibitor-lipid conjugates in vitro

    Y. Hattori, Y. Nagaoka, M. Kubo, H. Yamasaku, Y. Ishii, H. Okita, H. Nakano, S. Uesato, Y. Maitani

    Chem. Pharm. Bull.   59(11), 1386-1392   2011.11

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  • A potent inhibitor of SIK2, 3, 3′, 7-trihydroxy-4′-methoxyflavon (4′-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells

    A. Kumagai, N. Horike, Y. Sato, T. Uebi, T. Sasaki, Y. Itoh, Y. Hirata, K. Kitagawa, S. Uesato, H. Kawahara, H. Takemori, Y. Nagaoka

    PLoS ONE   6:e26148   2011.10

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  • New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group Reviewed

    Y. Kawaratani, T. Harada, Y. Hirata, Y. Nagaoka, S. Tanimura, M. Shibano, M. Taniguchi, M. Yasuda, K. Baba, S. Uesato

    Bioorg. Med. Chem.   19, 3995–4003   2011.4

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  • Downregulation of SIK2 expression promotes the melanogenic program in mice Reviewed

    Nanao Horike, Ayako Kumagai, Yuko Shimono, Tomoko Onishi, Yumi Itoh, Tsutomu Sasaki, Kazuo Kitagawa, Osamu Hatano, Hiroaki Takagi, Teruo Susumu, Hiroshi Teraoka, Ken-ichi, Yasuo Nagaoka, Hidehisa Kawahara, Hiroshi Takemori

    Pigment Cell Melanoma Res.   23; 809–819 (2010)   2010.10

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  • Therapeutic Effect of Arctiin and Arctigenin in Immunocompetent and Immunocompromised Mice Infected with Influenza A Virus

    Kyoko Hayashi, Kazuto Narutaki, Yasuo Nagaoka, Toshimitsu Hayashi, Shinichi Uesato

    Biol. Pharm. Bull.   2010.7

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  • Molecular bases of cyclodextrin adapter interactions with engineered protein nanopores

    Arijit Banerjee, Ellina Mikhailova, Stephen Cheley, Li-Qun Gu, Michelle Montoyac, Yasuo Nagaoka, Eric Gouaux, Hagan Bayley

    Proc Natl Acad Sci U S A   2010.5

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  • Histone Deacetylase Inhibitor Prodrugs in Nanoparticle Vector Enhanced Gene Expression in Human Cancer Cells

    Y. Ishii, Y. Hattori, T. Yamada, S. Uesato, Y. Maitani, Y. Nagaoka

    Euro. J. Med. Chem   2009.11

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  • Inhibitory Effect of (-)-Epigallocatechin and (-)-Epigallocatechin Gallate against Heregulin β1-Induced Migration/Invasion of the MCF-7 Breast Carcinoma Cell Line

    Yukihiro Kushima, Kazuki Iida, Yasuo Nagaoka, Yasuyuki Kawaratani, Tatsuya Shirahama, Minoru Sakaguchi, Kimiye Baba, Yukihiko Hara, Shinichi Uesato

    Biol. Pharm. Bull.   32 (5), 899-904   2009

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  • Investigation of the antibacterial activity of 3-O-octanoyl-(-)-epicatechin

    T.P.T. Cushnie, P.W. Taylor, Y. Nagaoka, S. Uesato, Y. Hara, A.J. Lamb

    J. Appl. Micorob.   105 (2008) 1461-1469   2008

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  • Peptide Backbone Mutagenesis of Putative Gating Hinges in a Potassium Ion Channel

    Y. Nagaoka, L. Shang, A. Banerjee, H. Bayley, S. J. Tucker

    ChemBioChem   9, 1725-1728   2008

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  • Growth Inhibition of Human Colon Cancer Cell Line HCT116 by Bis [2-(acylamino)phenyl] Disulfide and Its Action Mechanism

    S. Yamakawa, A. Demizu, Y. Kawaratani, Y. Nagaoka, Y. Terada, S. Maruyama, S. Uesato

    Biol. Pharm. Bull   31 (5), 916-920   2008

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  • Effects of Phosphorylation of Immunomodulatory agent FTY720 (Fingolimod) on antiproliferative activity against breast and colon cancer cells

    Y. Nagaoka, K. Otsuki, T. Fujita, S. Uesato

    Biol. Pharm. Bull   31 (6), 1177-1181   2008

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  • Attempt to Detect Natural Anticancer Compounds-Protein Binding through Precursor Ion Scan and MS/MS Measurements

    J. Negishi, T. Shirahama, Y. Nagaoka, Y. Takemoto, S. Uesato

    J. Pharm. Soc. Japan   128(9), 1317-1323   2008

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  • Examination of Anti-proliferative Activities of (-)-Epogallocatechin against HCT116 Colorectal Carcinoma Cells Reviewed

    Hiroyuki Inaba, Yasuo Nagaoka, Yukihiro Kushima, Ayako Kumagai, Yoshinori Matsumoto, Minoru Sakaguchi, Kimiye Baba, Shinichi Uesato

    Biol. Pharm. Bull. 31(1), 79-84 (2008)   31(1), 79-84   2008

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  • Ion channels of N-terminally linked alamethicin dimers: Enhancement of cation-selectivity by substitution of Glu for Gln at position 7

    Takashi Okazaki, Yasuo Nagaoka, Koji Asami

    Bioelectrochemistry 70, 380–386 (2007)   70, 380–386   2007

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  • Stereoselective conversion of anhydrovinblastine into vinblastine utilizing an anti-vinblastine monoclonal antibody as a chiral mould

    Tatsuya Shirahama, Takeyuki Kohno, Tomohiro Kaijima, Yasuo Nagaoka, Daisuke Morimoto, Kazumasa Hirata, Shinichi Uesato

    Chem. Pharm. Bull., 54(5), 665-668 (2006)   54(5), 665-668   2006

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  • Synthesis and cancer antiproliferative activity of new histone deacetylase inhibitors: hydrophilic hydroxamates and 2-aminobenzamide-containing derivatives

    Y. Nagaoka, T. Maeda, Y. Kawai, D. Nakashima, T. Oikawa, K. Shimoke, T. Ikeuchi, H. Kuwajima, S. Uesato

    European Journal of Medicinal Chemistry 41(6), 697–708 (2006)   41(6), 697–708   2006

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  • Cytoprotective effect of novel histone deacetylase inhibitors against polyglutamine toxicity

    Shingo Kariya, Makito Hirano, Shinichi Uesato, Yoshitaka Nagai, Yasuo Nagaoka, Yoshiko Furiya, Hirohide Asai, Nobuhiro Fujikake, Tatsushi Toda, Satoshi Ueno

    Neuroscience Letters 392(3), 213–215 (2006)   392(3), 213–215   2006

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  • Inhibitory effect of cancer cell proliferation by novel histone deacetylase inhibitors involves p21/WAFI induction and G2/M arrest

    T. Maeda, Y. Nagaoka, Y. Kawai, N. Takagaki, C. Yasuda, S. Yogosawa, Y. Sowa, T. Sakai, S. Uesato

    Biological and Pharmacentical Bullten   28巻5号849-853頁   2005.5

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  • Effect of 3-0-Octanoyl-(+)-catechin on the Responses of GABA A Receptors and Na+/Glucose Co transporters Expressed in Xenopus Oocytes

    H. Aoshima, Y. Okita, S. Hossain, K. Fukue, M. Mito, Y. Orihara, T. Yokoyama, A. Kumagai, Y. Nagaoka, S. Uesato

    Journal of Agricultural Food Chemistry   53巻1955-1959頁   2005.2

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  • Tumor Chemopreventive Effect of Orally Administered (-)-Epigallocatechin and its 3-0-Acylated Derivatives on the Two stage Mouse Skin Carcinogenesis

    Y. Nagaoka, A. Kumagai, Y. Tokuda, H. Nishino, S. Uesato

    Natural Medicines   59巻1号49-51頁   2005.1

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  • Tumor chemopreventive effect of orally administered (-)-epigallocatechin and its 3-O-acylated derivatives on the two stage mouse skin carcinogenesis induced by peroxynitrite and 12-O-tetradecanoylphorbol-13-acetate. Reviewed

    Yasuo Nagaoka, Ayako Kumagai, Harukuni Tokuda, Hoyoku Nishino, Yukihiko Hara, Shinichi Uesato

    Natural Medicine, 59(1), 49-51 (2005)   59(1), 49-51   2005

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  • そば殻成分が有する生理活性の探索とその構造 Reviewed

    河原秀久, 長岡康夫, 小幡 斉

    環境技術 34(7)474-479(2005)   34巻7号 474頁-479頁   2005

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  • Inhibitory effect of cancer cell proliferation by novel histone deacetylase inhibitors involves p21/WAF1 induction and G2/M arrest.

    Taishi Maeda, Yasuo Nagaoka, Yuki Kawai, Nobumasa Takagaki, Chikako Yasuda, Shingo Yogosawa, Yoshihiro Sowa, Toshiyuki Sakai, Shinichi Uesato

    Biol. Pharm. Bull., 28(5), 849-853 (2005).   28(5), 849-853   2005

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  • Effect of 3-O-Octanoyl-(+)-catechin on the Responses of GABAA Receptors and Na+/Glucose Cotransporters Expressed in Xenopus Oocytes and on the Oocyte Membrane Potential.

    Hitoshi Aoshima, Yoichi Okita, Sheikh Julfikar Hossain, Keiko Fukue, Mariko Mito, Yusuke Orihara, Terufumi Yokoyama, Mamoru Yamada, Ayako Kumagai, Yasuo Nagaoka, Shinichi Uesato, Yukihiko Hara

    J. Agric. Food Chem., 53, 1955-1959 (2005)   53, 1955-1959   2005

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  • Potent Histone Deacetylase Inhibitors: N-hydroxybenzamides with Antitumor Activities

    T. Maeda, Y. Nagaoka, H. Kuwajima, C. Seno, S. Maruyama, M. Kurotani, S. Uesato

    Bioorganic and Medicinal Chemistry   12巻4351-4360頁   2004.8

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  • Anti-Staphylococus aureus activity and oxacillin resistance modulating capacity of 3-0-acyl-catechins

    P. D. Stapleton, S. Shah, J. Miller, Y. Hara, Y. Nagaoka, A. Kumagai, S. Uesato, P. Taylor

    International Journal of Antimicrobial Agents   22巻1709-1716頁   2004.2

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  • Inhibitory Effects of 3-O-acyl-(+)-catechins on Epstein-Barr Virus Activation.

    S. Uesato, K. Taniuchi, A. Kumagai, Y. Nagaoka, R. Seto, Y. Hara, H. Tokuda, H. Nishino

    Chem. Pharm. Bull.   51/12, 1448-1450   2003.12

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  • Ion channels of alamethicin dimer N-terminally linked by disulfide bond.

    T. Okazaki, M. Sakoh, Y. Nagaoka, K. Asami

    Biophys. J.   85, 267-273   2003.7

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  • N-terminal insertion of alamethicin in channel formation studied using its covalent dimer N-terminally linked by disulfide bond Reviewed

    M. Sakoh, T. Okazaki, Y. Nagaoka, K. Asami

    Biochim. Biophys. Acta   1612, 117-121   2003.7

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  • Asymmetric Michael-aldol tandem cyclization of ┣T00360┫-oxo-┣T00210┫,┣T00220┫-unsaturated esters with 10-mercaptoisoborneol methyl ether Reviewed

    K. Nishimura, H. Tsubouchi, M. Ono, T. Hayama, Y. Nagaoka, K. Tomioka

    Tetrahedron Lett.   44, 2323-2326   2003.2

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  • Antiproliferative Activity of Some Catechins against Her2/neu-Overexpressing Human Breast Carcinoma SKBR3 Reviewed

    NAGAOKA Yasuo, T. Maeda, Y. Nagaoka, S. Kobayashi, Y. Hara, H. Tokuda, H. Nishimo, S. Uesato

    Natural Medicines   57/1, 31-33   2003.1

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  • Peptaibolとその誘導体のイオンチャンネル特性 Reviewed

    長岡 康夫

    膜   28巻2号61-69頁   2003

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  • Tumor Chemopreventive Activity of 3-O-Acylated(-)-epigallocatechins

    A. Kumagai, Y. Nagaoka, T. Obayashi, Y. Terashima, H. Tokuda, Y. Hara, T. Mukainaka, H. Nishino, H. Kuwajima, S. Uesato

    Bioorg. Med. Chem.   11,5143-5148   2003

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  • Synthesis and Application of Chiral Bisphosphines through Lithiation-Conjugate Addition Tandem Cyclization of Chiral ┣T00210┫,┣T00220┫,┣T01010┫,┣T01020┫-Unsaturated Bisphosphine Oxide Reviewed

    Yasuo Ngaoka, Hideki Inoue, Nawal El-Kossi, Kiyoshi Tomioka

    chem.commun   2002/2,122-123   2002

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    Grant-in-Aid for Scientific Research 200004-200303

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  • Conjugate reduction-initiated tandem cyclization of a chiral ┣T00210┫,┣T00220┫,┣T01010┫,┣T01020┫-unsaturated bisphosphine oxide Reviewed

    Yasuo Nagaoka, Nawal El-Koussi, Shinichi Uesato, Kiyoshi Tomioka

    Tetrahedron Lett.   43/24,4355-4359   2002

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    Grant-in-Aid for Scientific Research 200004-200303

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  • A New Methodology for Synthesis of A Chiral Phosphinocarboxylic Acid Through Micael Cyclization-Aldol Tandem Reaction of Chiral ┣T00210┫,┣T00220┫,┣T01010┫,┣T01020┫-Unsaturated Bisphosphine Oxide and Application in Palladium-Catalyzed Asymmetric Allylic Alkylation Reviewed

    Hideki Inoue, Yasuo Nagaoka, kiyoshi Tomioka

    J.Org.Chem.   67/16,5864-5867   2002

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    Grant-in-Aid for Scientific Research 200004-200303

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  • Allenes Through Horner-Wadswoth-Emmons Olefination of Alkenylphosphonates

    Yasuo Nagaoka, Hideki Inoue, Kiyoshi Tomioka

    Phosphorous, Sulfurand Silicon   177/6,1843-4846   2002

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    Grant-in-Aid for Scientific Research 200004-200303

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  • Novel Histone Deacetylase Inhibitors: N-Hydroxycarboxamids Possessing a Terminal Bicyclic Aryl Group

    Shinichi Uesato, Manabu Kitagawa, Yasuo Nagaoka, Taishi Maeda, Hiroshi Kuwajima, Takao Yamori

    Bioorg. Med. Chem. Left.   12/10,1347-1349   2002

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    Grant-in-Aid for Scientific Research 200004-200303

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  • Modification of alamethicin ion channels by substitution of Glu-7 for Gln-7

    Koji Asami, Takashi Okazaki, Yasuaki Nagai, Yasuo Nagaoka

    Biophys.J.   83,219-228   2002

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  • Substituted Hydroxyureas as Urease Inhibitors

    Shinichi Uesato, Yuichiro Hashimoto, Masaru Nishino, Yasuo Nagaoka, Hiroshi Kuwajima

    Chem. Pharm. Bull.   50/9,1280-1282   2002

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    Grant-in-Aid for Scientific Research 200004-200303

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  • Synthesis of Allenes by Double Horner-Wadsworth-Emmons Reaction

    Hideki Inoue, Hiroshi Tsubouchi, Yasuo Nagaoka, Kiyoshi Tomioka

    Tetrahedron   58/1,83-90   2002

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    Grant-in-Aid for Scientific Research 200004-200303

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  • Electronic and Steric Control in Regioselective Addition Reaction of Organolithium Reagents with Enaldimines.

    Kiyoshi Tomioka, Yoshito Shioya, Yasuo Nagaoka, Ken-ichi Yamada

    J.Org.Chem.   66/21,7051-7054   2001

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    Grant-in-Aid for Scientific Research 200004200303

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  • アルケニルホスホナートを基盤とする炭素一炭素結合形成反応の開発 Reviewed

    長岡 康夫

    薬学雑誌   121巻11号771-779頁   2001

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    科研費基盤研究 200004-200303

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  • Total Synthesis of (-)-Neplanocin A by Using Lithium Thiolate-Initiated Michael-Aldol Tandem Cyclization Reaction

    Masashi Ono, Katsumi Nishimura, Hiroshi Tsubouchi, Yasuo Nagaoka, Kiyoshi Tomioka

    J.Org.Chem   66/24,8199-8203   2001

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    Grant-in-Aid for Scientific Research 200004200303

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  • Molecular Assembly and Gelating Behavior of Didodecanoylamides of ┣T00210┫,┣T00360┫-Alkylidenediamides. Reviewed

    Kiyoshi Tomioka, Takaaki Sumiyoshi, Shinobu Narui, Yasuo Ngaoka, Akira Iida, Yoshihisa Miwa, Tooru Taga, Minoru Nkano, Tetsuro H, a.

    J.Am.Che.Soc.   123/47,11817-11818   2001

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  • Catalytic Enantioselective Protonation of Lithium Ester Enolates Generated by Conjugate Addition of Arylthiolate Enoates.

    Katsumi Nishimura, Masashi Ono, Yasuo Nagaoka, Kiyoshi Tomioka

    Angew. Chem. Int. Ed, ,   40(2), pp.440-442   2001

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  • An activated phosphate for an efficient Amide and peptide coupling reagent

    Tomohisa Yasuhara, Yasuo Nagaoka, Kiyoshi Tomioka

    J. Chem. Soc. Perkin Trans. 1   2000/17,2901-2902   2000

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  • Chemoselective Alchoxycarbonylation Reagent Having Trifluoromethane-sulfonyl-4-trifluoromethylanilide as a Leaving Group

    Tomohisa Yasuhara, Yasuo Nagaoka, Kiyoshi Tomioka

    J. Chem. Soc. , Perkin Trans. 1   /,2233-2234   1999

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  • Efficient Cyclization of ┣T00360┫-Oxo-┣T00210┫, ┣T00220┫-Unsaturated Esters Using Lithium Thiolate-Initiated Michael-Aldol Tandem Reaction Reviewed

    Masashi Ono, Katsumi Nishimura, Yasuo Nagaoka, Kiyoshi Tomioka

    Tetrahedron Lett.   40/,pp.6979-6982   1999

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  • The Conjugate Addition-Aldol Tandem Reaction of ┣T00210┫, ┣T00220┫-Unsaturated Esters Catalyzed By Lithium Benzene thiolate Reviewed

    Masashi Ono, Katsumi Nishimura, Yasuo Ngaoka, Kiyoshi Tomioka

    Tetrahedron Lett.   40/8,1509-1512   1999

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  • Cyclization of ┣T00210┫,┣T00220┫,┣T01020┫,┣T00360┫-unsaturated bisphosphonates using organolithium-initiated conjugate addition-Michael tandem reaction Reviewed

    Yasuo Nagaoka, Kiyoshi Tomioka

    Org. Lett.   1/9,pp.1467-1469   1999

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  • Enantioselective Conjugate Addition of Diethylzinc to Cyclohexanone Catalyzed by Chiral Amidophosphine-Copper(┣K00420┫) Triflate

    T. Mori, K. Kosaka, Y. Nakagawa, Y. Nagaoka, K. Tomioka

    Tetrahedron Asymmetry   9/,3175-3178   1998

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  • Structural Requirements of a Chiral Ligand for the Catalytic Asymmetric Addition of Thiophenol to ┣T00210┫, ┣T00220┫-Unsaturated Esters. Reviewed

    K. Tomioka, M. Okuda, K. Nishimura, S. Manabe, M. Kanai, Y. Nagaoka, K. Koga

    Tetrahedron Lett.   39/15,2141-2144   1998

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  • An External Chiral Amidophosphine Ligand for Asymmetric Conjugate Addition of Organocopper

    Y. Nakagawa, M. Kanai, Y. Nagaoka, K. Tomioka

    Tetrahedron   54/35,10295-10307   1998

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  • Asymmetrical membrane fluidity of bovine adrenal chromaffin cells and granules and effect of trichosporin-B-Vla

    S. Kitagawa, E. Tachikawa, T. Kashimoto, Y. Nagaoka, A. Iida, T. Fujita

    Biophys. Biochem. Acta.   1375/,93-100   1998

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  • Baylis-Hillman Type Carbon-Carbon Bond Formation of Alkenylphosphonates by the Action of Lithium Diisopropylamine

    Y. Nagaoka, K. Tomioka

    J. Org. Chem.   63/19 pp.6428-6429   1998

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  • Steric Tuning of Reactivity and Enantioselectivity in Addition of Thiophenol to ┣T00210┫, ┣T00220┫-Unsaturated Esters Mediated by a Chiral Ligand Reviewed

    K. Nishimura, M. Ono, Y. Nagaoka, K. Tomioka

    J. Am. Chem. Soc.   119/52,pp.12974-12975   1997

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  • Fungal Metabolites. XXI. Characteristics of Low Energy Collision Induced Dissociation of [M+2H]2+, [M+H+Na]2+ and [M+2Na]2+ of Peptaibols Using Electrospray Ionization Mass Spectrometry

    M. Kanai, A. Iida, Y. Nagaoka, S. Wada, T.Fujita

    J. Mass Spectromet.   31/,177-183   1996

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  • Structural Reguirements of an External, Chiral Amidophosphine Ligand for Asymmetric Reaction of an Organocopper Reagent(##)

    Y. Nakagawa, M. Kanai, Y. Nagaoka, K. Tomioka

    Tetrahedron Lett.   37/43,7805-7808   1996

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  • Role of Proline Residue in the Channel-Forming and Catecholamine-Releasing Activities of the Peptaibol, Trichosporin-B-Vla(##)

    Y. Nagaoka, A. Iida, T. Kambara, K. Asami, E. Tachikawa, T. Fujita

    Biophys. Biochem. Acta.   1283pp.31-36   1996

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  • Role of Gln7 in the Ion-Channel-Forming Properties of a Peptaibol, Trichosporin-B-Vla

    Y. Nagaoka, A. Iida, T. Kambara, K. Asami, E. Tachikawa, T.Fujita

    J. Chem. Soc., Chem. Commun,   1996/9,1079-1080   1996

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  • Pathway for Ca2+ Influx into Cells by Trichosporin-B-IVa, An ┣T00210┫-Aminoisobutyric acid-containing Peptide, from the Fungus Trichoderma polysporum(##)

    E. Tachikawa, N. Nogimori, S. Takahashi, K. Mizuma, K. Itoh, T. Kashimoto, Y. Nagaoka, A.Iida, T.Fujita

    Biophys, Biochem, Acta,   1282/,140-148   1996

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  • Fungal Metaboltes. XX. Effect of Proline Residue on the Structure of Ion-Channel-Forming Peptide, Trichosporin B-VIa

    Y. Nagaoka, A. Iida, E. Tachikawa, T. Fujita

    Chem. Pharm. Bull.   43/7,pp.1119-1124   1995

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  • Ion Channel Forming Properties of Antibiotic Peptides, Trichosporin-B-Vla and Its Derivatives, in Planar Lipid Bilayers

    NAGAOKA Yasuo

    Peptide Chemistry 1994   /,97-100   1995

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  • Structure Determination of Ion Channel Forming Peptides, Trichosporins, in a Complex Mixture by LC/ES-MSMS

    NAGAOKA Yasuo

    Peptide Chemistry 1994   /,277-280   1995

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  • Ion-channel-forming and Catecholamine-releasing Activities of Elongated and truncated Analogues of Trichosporin-B

    Y. Nagaoka, A. Iida, T. Kambara, K. Asami, T.Fujita

    J. Chem. Soc., Chem. Commun,   1995/21,2203-2204   1995

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  • Properties of Trichosporin-B-Vla-Induced Catecholomine Secretion from Bovine Adrenal Chromaffin Cells

    E. Tachikawa, S. Takahashi, K. Mizuma, T. Kashimoto, Y. Nagaoka, A. Iida, T. Fujita

    Biol. Pharm. Bull.   18/8,1165-1167   1995

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  • Structure and function of channel forming peptides. trichosporin-B-Vla and Aib14-trichosporin-B-Vla in lipid bilayers and biomembranes

    NAGAOKA Yasuo

    Peptide Chemistry   1993,361-364   1994

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  • Fungal Metabolites. Part17. Synthesis and NMR Study of Ion Channel-forming Peptides, Trichosporin B-Vla and Its Derivative.

    Y. Nagaoka, A. Iida, T. Fujita

    Chem. Pharm. Bull.   42/6,1258-1263   1994

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  • Fungal Metabolites. Part15. Primary Structures of Antibiotic peptides, Hypelcins B-I, B-II, B-III, B-IV, B-V, from Hypocrea peltata Reviewed

    NAGAOKA Yasuo, K. Matsauura, O. Shima, Y. Takeda, Y. Takaishi, Y.Nakaoka, T. Fujita

    Chem. Pharm. Bull.   42/5,1063-1069   1994

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  • Fungal Metabolites. Part15. Primary Structures of Antibiotic peptides, Hypelcins B-I, B-II, B-III, B-IV, B-V, from Hypocrea peltata

    NAGAOKA Yasuo, K. Matsauura, O. Shima, Y. Takeda, Y. Takaishi, Y.Nakaoka, T. Fujita

    Chem. Pharm. Bull.   42/5,1063-1069   1994

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  • Synthesis of 6-Methoxy-5,8-Quinolinediones and 8-Methoxy-5,6-Quinolinediones using Oxidative Demethylation with Cerium Ammonium Natrate

    Y. Kitahara, Y. Nagaoka, T. Matsumura, A. Kubo

    Heterocycles   38/3,659-678   1994

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  • Fungal Metabolites Part10. The Effect of Peptide Antibiotics, Trichosporin-Bs, on the Respiratory Activity of Mitochondria

    M. Okuda, A. Iida, S. Uesato, Y. Nagaoka, T. Fujita, Y. Takaishi, H.Terada

    Biol. Pharm. Bull.   17/4,482-485   1994

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  • Fungal Metabolites. Part9. Synthesis of Membrane-Modifying Peptide, Hypelcin A-III, from Hypocrea peltata

    K. Matsuura, A. Yesilada, A. Iida, Y. Nagaoka, Y. Takaishi, T. Fujita

    Chem. Pharm. Bull   41,1955-1959   1993

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  • Fungal Metabolites. Part5, Rapid Structure Elucidation of Antibiotic Peptides, Minor Compornents of Trichosporin Bs from Trichoderma polysporum

    J. Iida, A. Iida, Y. Takahashi, Y. Takaishi, Y. Nagaoka, T. Fujita

    J. Chem. Soc. Parkin Trans. 1   1993/2,357-365   1993

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  • Fungal Metabolites. Part6. Nuclear Magnetic Resonance Study of Antibiotic Peptides, Trichosporin Bs, from Trichoderma polysporum

    A. Iida, S. Uesato, T. Shingu, M. Okuda, Y. Nagaoka, Y. Kuroda, T. Fujita

    J. Chem. Soc. , Parkin Trans. 1   1993/2,367-373   1993

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  • Fungal Metabolites. Part5, Rapid Structure Elucidation of Antibiotic Peptides, Minor Compornents of Trichosporin Bs from Trichoderma polysporum Reviewed

    J. Iida, A. Iida, Y. Takahashi, Y. Takaishi, Y. Nagaoka, T. Fujita

    J. Chem. Soc. Parkin Trans. 1   1993/2,357-365   1993

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  • Fungal Metabolites. Part7, Solution Structure of an Antibiotic Peptide, Trichosporin B-V, from Trichoderma polysporum

    A. Iida, S. Uesato, T. Shingu, Y. Nagaoka, Y. Kuroda, T. Fujita

    J. Chem. Soc. , Parkin Trans, 1   1993/2,381-387   1993

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  • Structure-Activity Relationships of Antibiotic Peptides which Cause Ca2+-Dependent Catecholamine Release

    NAGAOKA Yasuo

    J. Pharmacobio-Dyn   15,S-10   1992

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  • Isolation and Structure-Activity Relationships of Antibiotic Peptides, Trichosporin-Bs, which Cause Ca2+-Dependent Cafecholamine Release from Adrenal Medullary Chromoffin Cells

    NAGAOKA Yasuo

    J. Pharmacobio-Dyn   14,S-106   1991

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  • Trichosporin-┣T00220┫-┣K00430┫, an ┣T00210┫-Aminoisobutyric Acid-Containing Peptide, Causes Ca2+ -Dependent Catecholamine Secretion from Adrenal Medullary Chromaffin Cells Reviewed

    E. Tachikawa, S. Takahashi, K. Furumachi, T. Kashimoto, A.Iida, Y. Nagaoka, T.Fujita

    Molecular Pharmacology   40/   1991

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Books

  • Modern Allene Chemistry

    H. Ohno, Y. Nagaoka, K. Tomioka, Norbert Krause(ed.)( Role: Joint author)

    Wiley  2004 

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MISC

  • Building an International Network ExchangeProgram of Education and Research for Graduate Course Students in Life and Biotechnology

    T. Oikawa, S. Uesato, H. Tamura, H. Kawahara, Y. Nagaoka, K. Shimoke, T. Tsuchido, L. Eggeling, Volker F. Wendisch, Jochen Buchs, Ratana Rujiravanit, Nazalan Najimudin, Chan Lai Keng

    Science and technology Report of Kansai University   50, 83-94   2008

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  • Hair-growth stimulating activity of biflavones from Ginkgo biloba

    Yasuo Nagaoka, Norihisa Yasuda, Itsuki Kuwajima, Shinich Uesato

    ICPH2007 3rd International Conference on Polyphenols and Health   Abstract pp. 253 (P200)   2007.11

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  • Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (-)-epicatechin against HCT 116 coloncancer cell

    Shinichi Uesato, Hiroyuki Inaba, Yasuo Nagaoka, Minoru Sakaguchi, Kimie Baba, Yukihiko Hara

    ICPH2007 3rd International Conference on Polyphenols and Health   Abstract pp. 275 (P237)   2007.11

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  • (-)-Eepigallocatechin-3-gallate and (-)-epigallocatechin inhibit herigulin b1-induced migration/invasion of MCF-7 breast carcinoma cell line

    Yukihiro Kushima, Kazuki Iida, Yasuo Nagaoka, Yukihiko Hara, Shinichi Uesato

    ICPH2007 3rd International Conference on Polyphenols and Health   Abstract pp. 303 (P289)   2007.11

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  • Proceeding of the International Symposium in Science and Technology 2007

    Yukihiro Kushima, Kazuki Iida, Yasuo Nagaoka, Shinichi Uesato

    Collaboration between ASEAN Countries in Environment and Life Sciences   PO-19   2007

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  • Explorative Study of Hair Growth Stimulants in Plants from Malaysia-Collaboration Work with Prof. Chan-, Proceeding of the International Symposium in Science and Technology 2007

    Yasuo Nagaoka

    Collaboration between ASEAN Countries in Environment and Life Sciences   BT-7   2007

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  • Proceeding of the International Symposium in Science and Technology 2007

    Yukihiro Kushima, Kazuki Iida, Yasuo Nagaoka, Shinichi Uesato

    Collaboration between ASEAN Countries in Environment and Life Sciences   PO-19   2007

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  • Cicadapeptins from a Fungus Isaria sinclairii Inhibit Acetylcholine- Evoked Secretion of Catecholamines from Bovine Adrenal Chromaffin Cells

    Yasuo Nagaoka, Kousuke Hata, Naofumi Fukata, Shinichi Uesato, Junya Ueda, Keiichiro Higashi, Shuji Uchida, Tetsuro Fujita, Shigeo Sasaki, Eiichi Tachikawa, Hitoshi Ishida(ed), Hisakazu Mihara(ed)

    Peptide Science 2006, Japanese Peptide Society.   248   2006

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  • Proceeding of the international conference of 43rd Japanese peptide symposium and 4th peptide engineering meeting

    Yasuo Nagaoka, Kousuke Hata, Naofumi Fukata, Shinichi Uesato, Junya Ueda, Keiichiro Higashi, Shuji Uchida, Tetsuro Fujita, Shigeo Sasaki, Eiichi Tachikawa

    43JPS/PEM4   5-8   2006

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  • 非天然アミノ酸のタンパク質への位置特異的導入法, 工学と技術

    深田尚文, 森山里美, 長岡康夫

    工学と技術   13(4)80-83   2006

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  • New Histone Deacetylase Inhibitors: Benzamide derivatives with a 2-hydroxyethylamino group

    Yasuo Nagaoka, Taishi Maeda, Shinichi Uesato

    230th ACS National Meeting, Abstracts of Papers,MEDI 362   2005.8

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Presentations

  • 脂質に対するヘアブリーチ剤添加や紫外線照射で生じる過酸化最終産物としてのアルデヒド体の分析

    北山 真太郎, 福﨑 大地, 光桑野 有理, 堀部 一平, 住吉 孝明, 長岡 康夫

    第67回日本薬学会近畿支部総会・大会  2017.10 

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    Venue:神戸  

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  • Neuroprotective mechanism of biflavones isolated from leaves of Japanese umbrella-pine tree, Sciadopitys verticillata

    K. Kawakami, Y. Tanaka, T. Sumiyoshi, Y. Nagaoka

    The 12th International Symposium in Science and Technology 2017  2017.8 

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    Venue:Penang Malaysia  

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  • Identification of aldehydes as lipid peroxidation end-product in hair and scalp formed under the hair bleaching or UV irradiation conditions

    D. Fukuzaki, Y. Kokuwano, S. Kitayama, T. Sumiyoshi, Y. Nagaoka

    The 12th International Symposium in Science and Technology 2017  2017.8 

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    Venue:Penang Malaysia  

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  • Design and synthesis of PEGylated peptide micellar formulation for cancer gene therapy

    T. Inada, M. Katsuragi, G. Kimura, T. Sumiyoshi, Y. Nagaoka

    The 12th International Symposium in Science and Technology 2017  2017.8 

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    Venue:Penang Malaysia  

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  • Effect of histone deacetylase inhibitors on transfection of IFN-β anti-cancer therapeutic gene into human breast cancer cells –toward combination gene therapy

    R. Sueyoshi, R. Nishimura, T. Sumiyoshi, Y. Nagaoka

    The 12th International Symposium in Science and Technology 2017  2017.8 

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    Venue:Penang Malaysia  

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  • Substitution of oxygen to nitrogen in flavone structure

    H. Katsumoto, H. Iibata, H. Nishisako, T. Sumiyoshi, Y. Nagaoka

    The 12th International Symposium in Science and Technology 2017  2017.8 

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    Venue:Penang Malaysia  

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  • Histone Deacetylase Inhibitors as Lipofection Enhancer

    S. Mashi, T. Sumiyoshi, Y. Nagaoka

    The 11th International Symposium in Science and Technology 2016  2016.7 

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    Venue:Osaka  

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  • p53-mdmx結合を選択的に阻害する低分子化合物K-178の創製とこれを基盤とする 構造最適化

    松江 紗希, 松浦 佳宏, 竹本 涼穂, 長岡 康夫, 江成 政人, 上里 新一

    日本薬学会第134年会  2014.3 

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    Venue:熊本  

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  • リポフェクション導入CDC6標的がん治療遺伝子の作用に及ぼすヒストン脱アセチル化酵素阻害剤の併用効果

    小林 真里子, 相原 浩人, 吉野 宏美, 上條 洋士, 上里 新一, 長岡 康夫

    日本薬学会第134年会  2014.3 

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    Venue:熊本  

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  • 食品バイオマスバナナ外果皮からの抗がん活性成分の探索

    西迫 久晃, 鯰江 清裕, 長岡 康夫, 上里 新一

    日本薬学会第134年会  2014.3 

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    Venue:熊本  

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  • トキワムシゴケ由来デプシド誘導体のメラニン産生抑制活性とその機構

    武富 翔, 米山 千裟, 竹森 洋, 熊谷 彩子, 河原 秀久, 上里 新一, 長岡 康夫

    日本薬学会第134年会  2014.3 

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    Venue:熊本  

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  • p53-Mdmx結合阻害低分子化合物の創製と構造活性相関―がん細胞に対する細胞毒性と作用機作の評価

    古座谷昭典, 松江紗希, 松浦佳宏, 竹本涼穂, 長岡康夫, 江成政人, 上里新一

    第63回日本薬学会近畿支部総会・大会  2013.10 

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    Venue:同志社女子大学  

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  • 4'-O-METHYLATED FLAVONES AS ENHANCER OF MELANOGENESIS

    Mako Tamano, Yukihiro Yoshimoto, Ayako Kumagai, Hiroshi Takemori, Ippei Horibe, Shinichi Uesato, Yasuo Nagaoka

    49th International Conference on Medicinal Chemistry (RICT 2013)  2013.7 

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    Venue:Nice, France  

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  • ANTITUMOR EFFECT OF PEGYLATED HISTONE DEACETYLASE INHIBITOR

    Hiroto Kamijo, Mariko Kobayashi, Mako Tamano, Yukihiro Yoshimoto, Shinichi Uesato, Yasuo Nagaoka

    49th International Conference on Medicinal Chemistry (RICT 2013)  2013.7 

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    Venue:Nice, France  

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  • HDAC阻害剤のがん細胞特異的リポフェクション効率向上効果

    吉野宏美, 小林真里子, 上條洋士, 水嶋恭子, 上里新一, 長岡康夫

    日本薬学会第133年会  2013.3 

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    Venue:パシフィコ横浜  

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  • コウヤマキ葉含有ビフラボン類のB16メラノーマ細胞に対するメラニン産生促進活性とその機構の解明

    佐藤雄大, 吉本幸広, 玉野真子, 竹森 洋, 熊谷彩子, 上里新一, 長岡康夫

    日本薬学会第133年会  2013.3 

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    Venue:パシフィコ横浜  

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  • 食品廃棄物由来のフェノールオキシダーゼを用いた酸化染毛剤の開発

    前川琴子, 高智純哉, 上里新一, 長岡康夫

    日本薬学会第133年会  2013.3 

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    Venue:パシフィコ横浜  

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  • Biflavones isolated from the Leaves of Sciadopitys verticillata Induce Melanogenesis in B16 Melanoma Cells

    Yukihiro Yoshimoto, Yudai Sato, Yuki Shiota, Sho Taketomi, Shinichi Uesato, Yasuo Nagaoka

    7th International Symposium in Science and Technology  2012.8 

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    Venue:Universiti Sains Malaysia, Penang, Malaysia  

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  • Search for histone deacetylase inhibitors possessing a new active site-binding domain

    Maho Yamamoto, Hiromasa Ishiwatari, Yoshiyuki Hirata, Yasuo Nagaoka, Shinichi Uesato

    7th International Symposium in Science and Technology  2012.8 

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  • Histone Deacetylase Inhibitors as Lipofection Enhancer

    Hiroto Kamijo, Hiromi Yoshino, Mariko Kobayashi, Kyoko Mizushima, Shinichi Uesato, Yasuo Nagaoka

    7th International Symposium in Science and Technology  2012.8 

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    Venue:Universiti Sains Malaysia, Penang, Malaysia  

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  • Structure Activity Relationship of Flavonoids in Enhancement of Melanogenesis in B16 Murine Melanoma Cells

    Yasuo Nagaoka, Shinichi Uesato, Hidehisa Kawahara, Hiroshi Takemori (医薬基盤研)

    7th International Symposium in Science and Technology  2012.8 

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    Venue:Universiti Sains Malaysia, Penang, Malaysia  

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  • Melanogenesis Inhibitory Effects of Acetone Extracts of Lichen, Thamnolia subuliformis from Commercialized Snow Tea

    Chinami Azuma, Yuko Shimono, Yasuo Nagaoka, Yoshio Katakura, Hidehisa Kawahara

    7th International Symposium in Science and Technology  2012.8 

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    Venue:Universiti Sains Malaysia, Penang, Malaysia  

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  • ENHANCED EFFECT OF HISTONE DEACETYLASE INHIBITORS ON THE EXPRESSION OF LIPOFECTED GENES

    Mariko Kobayashi, Hiromi Yoshino, Hiroto Kamijo, Kyoko Mizushima, Saki Matsue, Shinichi Uesato, Yasuo Nagaoka

    48th International Conference on Medicinal Chemistry (RICT 2012)  2012.7 

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    Venue:Poitiers, France  

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  • Induction of Melanogenesis with Biflavonoids in B16 Melanoma Cells Caused by Upregulation of CREB

    Sho Taketomi (D), Yudai Sato (D), Yuki Shiota (D), Ayako Kumagai (D), Mariko Kobayashi (D), Shinichi Uesato, Yasuo Nagaoka

    48th International Conference on Medicinal Chemistry (RICT 2012)  2012.7 

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    Venue:Poitiers, France  

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  • 亜鉛結合部位にチエニル基をもつ新規経口性ヒストン脱アセチル化酵素阻害剤K-560

    平田佳之 (D), 平田雅彦(大阪薬大), 芝野真喜雄(大阪薬大), 谷口雅彦(大阪薬大), 安田正秀(大阪薬大), 大桃善朗(大阪薬大), 瓦谷泰之(D), 長岡康夫,, 馬場きみ江(大阪薬大), 上里新一

    日本薬学会第132年会  2012.3 

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    Venue:北海道大学  

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  • ヒストン脱アセチル化酵素阻害剤とその誘導体のリポフェクションに及ぼす影響

    長岡康夫, 吉野宏美 (D), 小林真里子(M), 置田裕子(D), 中野宏樹(D), 上里新一

    日本薬学会第132年会  2012.3 

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    Venue:北海道大学  

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  • 安全性の高い酸化染毛剤の開発について

    長岡康夫, 前川琴子(D)

    第16回関西大学先端科学技術シンポジウム  2012.1 

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    Venue:関西大学  

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  • Antitumor activity of new histone deacetylase inhibitors possessing a 2-tyienyl-substituted 2-aminobenzamide moiety

    Y. Hirata (D), M. Shibano (大阪薬大), M. Taniguchi (大阪薬大), M. Yasuda (大阪薬大), K. Baba (大阪薬大), Y. Nagaoka, M. Hirata (大阪薬大), Y. Ohmomo (大阪薬大), S. Uesato

    8th AFMC International Medicinal Chemistry Symposium (AIMECS11)  2011.11 

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  • Histone Deacetylase Inhibitors as Lipofection Enhancer

    H. Yoshino (D), M. Kobayashi (B), H. Okita (D), H. Nakano (D), S. Uesato, Y. Nagaoka

    8th AFMC International Medicinal Chemistry Symposium (AIMECS11)  2011.11 

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    Venue:京王プラザホテル(東京)  

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  • Structure-activity relationship of new microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group

    Y. Kawaratani (D), T. Harada (D), Y. Hirata (D), Y. Nagaoka, S. Tanimura, S. Uesato

    8th AFMC International Medicinal Chemistry Symposium (AIMECS11)  2011.11 

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  • Mechanistic and Structural Bases of Oxidation Hair Dyes Based on Polyphenols

    T. Maekawa (D), A. Mizuta (B), K. Yoneda (B), H. Yoshino (D), K. Takahashi (中野製薬), S.Uesato, Y. Nagaoka

    5th International Conference on Polyphenols and Health (ICPH2011)  2011.10 

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    Venue:Sitges, Spain  

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  • Administration of Arctiin or Arctigenin to Mice for 2 Weeks before and after infection with influenza A virus decreased the severity of influenza infection

    S. Uesato, K. Hayashi(富山大), X. He (D), R. Koyama (D), Y. Nagaoka, T. Hayashi (富山大)

    5th International Conference on Polyphenols and Health (ICPH2011)  2011.10 

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    Venue:Sitges, Spain  

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  • Biflavones isolated from the Leaves of Sciadopitys verticillata Induce Melanogenesis in B16 Melanoma Cells

    Y. Sato (D), Y. Shiota (D), S. Taketomi (B), Y. Matsumori (B), S. Uesato, H. Takemori (医薬基盤研), Y. Nagaoka

    5th International Conference on Polyphenols and Health (ICPH2011)  2011.10 

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    Venue:Sitges, Spain  

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  • 類型の異なるヒストン脱アセチル化酵素阻害剤がリポフェクション効率におよぼす影響

    吉野宏美 (D), 置田裕子 (D), 中野宏樹 (D), 服部喜之(星薬大), 米谷芳枝(星薬大), 上里新一, 長岡康夫

    日本薬学会 131年会  2011.3 

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    Venue:静岡  

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  • リポフェクション効率向上効果を有するプロドラッグ化ヒストン脱アセチル化酵素阻害剤

    置田裕子 (D), 中野宏樹 (D), 吉田耕平 (B), 吉野宏美 (D), 上里新一, 服部喜之 (星薬大), 米谷芳枝 (星薬大), 長岡康夫

    日本薬学会 131年会  2011.3 

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    Venue:静岡  

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  • ビフラボン類のメラニン産生促進作用

    長岡康夫

    第15回 関西大学先端科学技術シンポジウム  2011.1 

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    Venue:関西大学100周年会館  

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  • B16メラノーマ細胞に対するビフラボン類のメラニン産生促進効果 -細胞に効く染毛剤を目指して-

    佐藤雄大(B), 塩田雄基(D), 熊谷彩子, 竹森洋(医薬基盤研), 上里新一, 長岡康夫, 小畑勝義(中野製薬), 堀部一平(中野製薬)

    第15回 関西大学先端科学技術シンポジウム  2011.1 

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    Venue:関西大学100周年会館  

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  • ニュートラルロススキャン法およびMS/MS法を用いたタキソール‐タンパク質複合体形成の確認について

    白浜辰弥, 武本佳樹, 山本智加, 根岸淳, 長岡康夫, 上里新一

    日本薬学会第129年会 (国立京都国際会館) 要旨集  2009.3 

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  • 硝酸エステル基を有する新規細胞周期G2/M制御化合物について

    瓦谷泰之, 寺田侑司, 拝師佳奈, 金子博, 平田佳之, 長岡康夫, 上里新一

    日本薬学会第129年会 (国立京都国際会館) 要旨集  2009.3 

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  • モノクローナル抗体を反応場としたタキソール合成の試み―抗タキソールモノクローナル抗体の作製

    武本佳樹, 白浜辰弥, 河野武幸, 辻琢己, 森實祐希, 長岡康夫, 上里新一

    日本薬学会第129年会 (国立京都国際会館) 要旨集  2009.3 

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  • 硫黄原子を有する新規ヒストン脱アセチル化酵素阻害剤の創生

    清川真吾, 長岡康夫, 上里新一

    日本薬学会第129年会(国立京都国際会館) 要旨集  2009.3 

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  • 新規経口ヒストン脱アセチル化酵素阻害剤K-197の抗腫瘍効果について

    上里新一, 清川真吾, 平田佳之, 長岡康夫, 芝野真喜雄, 谷口雅彦, 安田正秀, 馬場きみ江

    日本薬学会第129年会(国立京都国際会館) 要旨集  2009.3 

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  • 非ウイルスベクターによる外部導入遺伝子の発現を増強するヒストン脱アセチル化酵素阻害剤プロドラッグの開発

    石井佑太, 山田敏晴, 濱本和隆, 田中菜津子, 上里新一, 長岡康夫, 服部喜之, 米谷芳枝

    日本薬学会第129年会(国立京都国際会館) 要旨集  2009.3 

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  • 非小細胞肺がん株A549に対する化学療法剤とシークワーサー成分との併用効果について

    前田竜, 中島大輔, 十一元晴, 小野絵梨子, 長岡康夫, 上里新一

    日本薬学会第129年会 (国立京都国際会館) 要旨集  2009.3 

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  • ヒト非小胞細胞肺がん細胞株A549に対する緑茶カテキン類の細胞増殖抑制効果

    熊谷彩子, 長岡康夫, 小泉幸央, 飯田和樹, 小代田宗一, 上里新一, 杉山俊博

    日本薬学会第129年会 (国立京都国際会館) 要旨集  2009.3 

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  • 正電荷ナノ粒子ベクターによる外部導入遺伝子の発現を増強するヒストン脱アセチル化酵素阻害剤プロドラッグの開発

    長岡康夫, 山田敏晴, 石井佑太, 濱本和隆, 田中菜津子, 上里新一, 服部喜之, 米谷芳枝

    第27回メディシナルケミストリーシンポジウム, 講演要旨集  2008 

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    Venue:大阪  

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  • 経口性ヒストン脱アセチル化酵素阻害剤K-197の開発

    清川真吾, 前田泰司, 平田佳之, 長岡康夫, 芝野真喜雄, 谷口雅彦, 安田正秀, 馬場きみ江, 上里新一

    第27回メディシナルケミストリーシンポジウム, 講演要旨集  2008 

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    Venue:大阪  

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  • Hibiscus rosa-sinensis Linn. 抽出物の育毛活性

    長岡康夫, 廖彬池, 桑島 樹, 上里新一, Chan Lai Keng, Tan Chee Leng

    日本薬学会第128年会(横浜)要旨集  2008 

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  • ベルベリン及び関連化合物の抗ヒトサイトメガロウイルス活性について

    蓑田一貴, 長岡康夫, 上里新一, 林 京子, 林利光

    日本薬学会第127年会  2007.3 

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  • ビフラボン類の発毛促進活性

    長岡康夫, 安田法永, 上里新一, 荒木ひとみ, 栄原健志, 渡邊了之, 山下涌二郎

    日本薬学会第127年会  2007.3 

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  • 天然抗がん剤-タンパク質複合体の合成並びに質量分析による構造解析について

    白浜辰弥, 根岸 淳, 長岡康夫, 上里新一

    日本薬学会第127年会  2007.3 

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  • Wnt/-catenin経路を制御する新規化合物の探索と作用機序の解明

    山川智史, 寺田侑司, 瓦谷泰之, 出水 彩, 長岡康夫, 上里新一

    日本薬学会第127年会  2007.3 

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  • Hibiscus rosa-sinensis Linn. 抽出物の育毛活性

    長岡康夫, 廖彬池, 上里新一, Chan Lai Keng, Tan Chee Leng

    日本生薬学会第54回年会(名古屋)要旨集  2007 

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  • イチョウ葉由来の新規育毛活性成分

    長岡康夫

    秋田応用生命科学研究会第12回講演会講演要旨集  2007 

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  • Antiviral activity of berberine and related compounds against human cytomegalovirus

    Kyoko Hayashi, Kazuki Minoda, Yasuo Nagaoka, Toshimitsu Hayashi, Shinichi Uesato

    Bioorg. & Med. Chem. Lett.  2007 

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  • イチョウ葉ビフラボンの発毛促進活性

    長岡康夫, 安田法永, 荒木ひとみ, 栄原健志, 上里新一, 渡邉了之, 山下涌二郎

    日本生薬学会第53回年会(日本薬大・大宮)要旨集  2006.9 

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  • Diosgeninとその誘導体の育毛活性

    長岡康夫, 東 悦史, 小林真也, 上里新一, 齋藤節生

    日本生薬学会第53回年会(日本薬大・大宮)要旨集  2006.9 

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  • Her2/neu高発現乳癌に治療効果をもつ低分子性抗癌剤の探索研究

    出水 彩, 上里新一, 曽野良平, 山川智史, 長岡康夫

    第10回がん分子標的治療研究総会,創薬の新世代へ  2006.6 

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    Venue:東京  

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  • 免疫抑制剤FTY720とその類縁体のヒト乳がん細胞およびヒト大腸がん細胞に対する細胞増殖抑制効果

    大月孝太, 世良圭敬, 長岡康夫, 藤多哲朗, 上里新一

    第56回 日本薬学会近畿支部総会・大会 要旨集  2006 

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  • 食品含有天然物の生理活性について

    長岡康夫, 熊谷彩子, 上里新一

    第11回 先端科学技術シンポジウム(関西大学)要旨集  2006 

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  • Ion channels of N-terminally linked alamethicin dimers:Enhancement of cation-selectivity by substitution of Glu for Gln at position 7

    Takashi Okazaki, Yasuo Nagaoka, Koji Asami

    Bioelectrochemistry  2006 

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  • 2-ヒドロキシアミノ基を有する新規ヒストン脱アセチル化酵素阻害剤の創生

    前田泰司, 長岡康夫, 川合勇輝, 中島大輔, 犬伏規仁, 桑島博, 上里新一

    日本薬学会第126年会要旨集  2006 

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  • モノクローナル抗体を反応場として用いたanhydrovinblastineからvinblastineへの変換反応

    白浜辰弥, 貝島智博, 長岡康夫, 森本大介, 上里新一, 河野武幸

    日本薬学会第125年会要旨集  2005.3 

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    Venue:東京  

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  • 緑茶カテキン類を用いた肺発がん因子抑制作用の情報伝達系での解析

    熊谷彩子, 上里新一, 長岡康夫, 原 征彦, 円城文雄, 西野輔翼, 徳田春邦

    日本薬学会第125年会,要旨集  2005.3 

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    Venue:東京  

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  • 2環性芳香族炭化水素基を有する新規ヒストン脱アセチル化酵素阻害剤の抗腫瘍活性について

    前田泰司, 長岡康夫, 川合勇輝, 上里新一, 高垣伸匡, 与五沢真吾, 曽和義広, 酒井敏行, 瀬野千恵子, 丸山佐起子, 黒滝美音子

    日本薬学会第125年会,要旨集  2005.3 

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    Venue:東京  

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  • 抗vinblastineモノクローナル抗体を反応場として用いたdihydropyridinium中間体からvinblastineへの変換反応

    森本大介, 長岡康夫, 白浜辰弥, 貝島智博D, 上里新一, 河野武幸, 平田收正

    日本薬学会第125年会,要旨集  2005.3 

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    Venue:東京  

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  • O―メチル化フラボノイドの抗ウイルス活性

    長岡康夫, 簑田一貴, 口屋拓実, 上里新一, 林 京子, 林 利光

    日本薬学会第125年会,要旨集  2005.3 

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    Venue:東京  

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  • 化学発がん動物モデルを用いた,カテキン及びその誘導体の発がん予防効果の検討

    熊谷彩子, 上里新一, 長岡康夫, 徳田春邦, 西野輔翼, 原征彦

    第11回がん予防研究会  2004 

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  • カテキン及びその脂肪酸誘導体の発がん化学予防剤並びに抗MRSA剤としての応用研究

    熊谷彩子, 徳田春邦, 長岡康夫, 原征彦, 瀬戸龍太, 西野輔翼, Peter W. Taylor, Paul D. Stapleton, 上里新一

    日本生薬学会第51回年会,講演要旨集  2004 

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    Venue:神戸  

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Industrial property rights

  • N-hydroxy carboxamide derivatives

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    Application no:2002-045310  Date applied:2002.2

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Devising educational methods

  • パワーポイントを使った授業も行っているが、基本的には板書しながらの解説方式で講義を行うように心掛けている。学生にとって、講義を聞きながら板書を整理してノートにつけるといった能動的な行為が、まとまりのある、より深い理解に結びつくと信じている。

Teaching materials

  • 講義の理解の確認と内容のまとめを兼ねるような、穴埋め問題を組み込んだプリント教材を配布している。

Teaching method presentations

  •  特になし

Special notes on other educational activities

  •  特になし